METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
- CAS No.
- 95201-93-7
- Chemical Name:
- METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
- Synonyms
- Methyl-4-bromo-3-hydroxythophene2-carboxylate;4-Bromo-3-hydroxy-2-(methoxycarbonyl)thiophene;Methyl 4-bromo-3-hydroxythiophene-3-carboxylate;methyl 3-hydroxy-4-bromo-2-thiophenecarboxylate;METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE;methyl-3-hydroxy-4-bromo thiophen-2-carboxylate;(4-bromo-3-oxo-2-thiophenylidene)-methoxymethanolate;4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;2-Thiophenecarboxylic acid, 4-bromo-3-hydroxy-, methyl ester;METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB1329942
- Molecular Formula:
- C6H5BrO3S
- Molecular Weight:
- 237.07
- MDL Number:
- MFCD00052081
- MOL File:
- 95201-93-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | OR24351 | 100mg | $21 |
| methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | OR24351 | 250mg | $24 |
| methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | OR24351 | 1g | $33 |
| methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | OR24351 | 5g | $141 |
| methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | OR24351 | 25g | $695 |
| Melting point | 79-80°C |
|---|---|
| Boiling point | 247.9±35.0℃ (760 Torr) |
| Density | 1.803±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 103.7±25.9℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 7.93±0.15(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Sparingly Soluble in water 0.95 g/L @ 25°C. |
| InChI | InChI=1S/C6H5BrO3S/c1-10-6(9)5-4(8)3(7)2-11-5/h2,8H,1H3 |
| InChIKey | UFTXASQYKJFRKI-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)SC=C(Br)C=1O |
| CAS DataBase Reference | 95201-93-7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| HS Code | 2934999090 | |||||||||
| NFPA 704 |
|
METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR24351 | methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | 95201-93-7 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR24351 | methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | 95201-93-7 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR24351 | methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | 95201-93-7 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR24351 | methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | 95201-93-7 | 5g | $141 | 2026-06-04 | Buy |
| Apolloscientific | OR24351 | methyl 4-bromo-3-hydroxythiophene-2-carboxylate 97% | 95201-93-7 | 25g | $695 | 2026-06-04 | Buy |
METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Chemical Properties,Uses,Production
Uses
The synthesis of the thienopyranone scaffold began with the alkylation of methyl 4-bromo-3-hydroxythiophene-2-carboxylate with N-acetylmorpholine.
Synthesis
5118-06-9
95201-93-7
General procedure for the synthesis of methyl 4-bromo-3-hydroxythiophene-2-carboxylate from methyl 3-hydroxy-2-thiophenecarboxylate: 3.24 mL (63.2 mmol) of bromine was slowly added to a solution of 10 g (63.2 mmol) of methyl 3-hydroxy-2-thiophenecarboxylate in 22 mL of acetic acid and the reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was poured into 50 mL of water and extracted with 50 mL of dichloromethane. The organic phases were combined, washed twice with 50 mL of water and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (eluent: dichloromethane/petroleum ether, 1:2) to give 11.3 g methyl 4-bromo-3-hydroxythiophene-2-carboxylate in 76% yield. The melting point of the product was 86 °C. 1H NMR (CDCl3): δ 3.92 (s, 3H), 7.38 (s, 1H), 9.74 (s, 1H). 13C NMR (CDCl3): δ 52.2, 102.6, 103.8, 128.1, 160.4, 165.8. MS (EI): m/z = 236 (M+.). .
References
[1] Tetrahedron Letters, 2009, vol. 50, # 35, p. 5005 - 5008
[2] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1288 - 1291
[3] Synthesis, 1984, vol. NO. 10, p. 847 - 850
[4] Tetrahedron Letters, 2017, vol. 58, # 26, p. 2537 - 2541
[5] Patent: US4748183, 1988, A
METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3967 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Wuxi Rejoys chemical Technology Co., Ltd. | 0510-86103381 | sales@rejoyschem.com | CHINA | 976 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| GLR Innovations | -- | info@glrgroup.in | India | 4535 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8618662433356 | 3899766280@qq.com | China | 26362 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 6000 | 58 |
View Lastest Price from METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-06-30 | METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-02-02 | METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2020-02-19 | METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- METHYL 4-BROMO-3-HYDROXYTHIOPHENE-2-CARBOXYLATE
95201-93-7
- $7.00
- 99%
- Career Henan Chemical Co
