2-Chloro-5-acetylpyridine
- CAS No.
- 55676-22-7
- Chemical Name:
- 2-Chloro-5-acetylpyridine
- Synonyms
- 1-(6-Chloropyridin-3-yl)ethan-1-one;1-(6-CHLOROPYRIDIN-3-YL)ETHANONE;1-(6-CHLORO-3-PYRIDINYL)-1-ETHANONE;2-CHLORO-5-ACETYLPYRIDINE;3-Acetyl-6-chloropyridine;5-Acetyl-2-chloropyridine;6-CHLORO-3-ACETYLPYRIDINE;5-Acetyl-2-chloropyridine >1-(6-Chlorpyridin-3-yl)ethanon;1-(6-chloro-3-pyridinyl)ethanone
- CBNumber:
- CB1354254
- Molecular Formula:
- C7H6ClNO
- Molecular Weight:
- 155.58
- MDL Number:
- MFCD03407343
- MOL File:
- 55676-22-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Acetyl-2-chloropyridine >98.0%(GC) | A2796 | 1g | $40 |
| 5-Acetyl-2-chloropyridine >98.0%(GC) | A2796 | 5g | $121 |
| 3-Acetyl-6-chloropyridine Asreported | 260028 | 500mg | $360 |
| 3-Acetyl-6-chloropyridine Asreported | 260028 | 1g | $526 |
| 3-Acetyl-6-chloropyridine Asreported | 260028 | 2g | $761 |
| More product size | |||
| Melting point | 98 °C |
|---|---|
| Boiling point | 280.5±20.0 °C(Predicted) |
| Density | 1.233±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | -2.14±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C7H6ClNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3 |
| InChIKey | UXSNZYGTQTXRAD-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(Cl)N=C1)C |
| CAS DataBase Reference | 55676-22-7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| WGK Germany | WGK 3 |
| Hazard Note | Harmful |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
2-Chloro-5-acetylpyridine price More Price(97)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2796 | 5-Acetyl-2-chloropyridine >98.0%(GC) | 55676-22-7 | 1g | $40 | 2026-04-30 | Buy |
| TCI Chemical | A2796 | 5-Acetyl-2-chloropyridine >98.0%(GC) | 55676-22-7 | 5g | $121 | 2026-04-30 | Buy |
| Usbiological | 260028 | 3-Acetyl-6-chloropyridine Asreported | 55676-22-7 | 500mg | $360 | 2026-06-03 | Buy |
| Usbiological | 260028 | 3-Acetyl-6-chloropyridine Asreported | 55676-22-7 | 1g | $526 | 2026-06-03 | Buy |
| Usbiological | 260028 | 3-Acetyl-6-chloropyridine Asreported | 55676-22-7 | 2g | $761 | 2026-06-03 | Buy |
2-Chloro-5-acetylpyridine Chemical Properties,Uses,Production
Application
2-Chloro-5-acetylpyridine is also used industrially as a denaturant and dyeing aid.
Synthesis
923034-23-5
55676-22-7
Step 3 Synthesis of 1-(6-chloropyridin-3-yl)ethanone: Dimethyl 2-(6-chloronicotinoyl)malonate (89.8 g, 331 mmol) was dissolved in a solvent mixture of DMSO (445 mL) and water (11 mL), and the reaction was heated for 2.5 hr at 130 °C. After the reaction was completed, the reaction mixture was cooled and poured into H2O/ice (300 mL). The aqueous phase was extracted with EtOAc (4 x 150 mL). The organic phases were combined, washed with brine, dried and concentrated under reduced pressure. The residue was recrystallized by 60% ethanol-water solution to afford the target compound 1-(6-chloropyridin-3-yl)ethanone in a yield of 16.5 g (32% yield) as a yellow solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 23, p. 6093 - 6096
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 24, p. 6482 - 6485
[3] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 17; 19
[4] Tetrahedron, 1992, vol. 48, # 42, p. 9233 - 9236
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 18, p. 3041 - 3044
2-Chloro-5-acetylpyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Karry Pharmachem Co., Ltd. | 13131752837 | info@karrypharma.com | China | 34 | 58 |
| Nanjing Fred Technology Co., Ltd | +86-25-84696168 +86-15380713688 | Austin@fredbio.com | China | 2428 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14032 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3004 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2993 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
View Lastest Price from 2-Chloro-5-acetylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 2-Chloro-5-acetylpyridine
55676-22-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | 2-Chloro-5-acetylpyridine
55676-22-7
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd.
|
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2024-11-26 | 2-Chloro-5-acetylpyridine
55676-22-7
|
99% | 5 ton | Nanjing Fred Technology Co., Ltd |
-
- 2-Chloro-5-acetylpyridine
55676-22-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Chloro-5-acetylpyridine
55676-22-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Chloro-5-acetylpyridine
55676-22-7
- 99%
- Nanjing Fred Technology Co., Ltd
