1-(2-Chloroethyl)piperidine hydrochloride
- CAS No.
- 2008-75-5
- Chemical Name:
- 1-(2-Chloroethyl)piperidine hydrochloride
- Synonyms
- N-(2-CHLOROETHYL)PIPERIDINE HYDROCHLORIDE;PIPEC;1-(2-Chloroethyl)pip;Pramoxine Impurity 12;2-Piperidinoethyl chiloride;2-CHLOROETHYLPIPERIDINE HCL;PIPERIDINO ETHYL CHLORIDE HCL;2-ChloroethylpiperidineHcl98%;Levocloperastine CEP Impurity;N-(2-CHLOROETHYL)PIPERIDINE HCL
- CBNumber:
- CB1412444
- Molecular Formula:
- C7H15Cl2N
- Molecular Weight:
- 184.11
- MDL Number:
- MFCD00012837
- MOL File:
- 2008-75-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-(2-Chloroethyl)piperidine hydrochloride 98% | C42602 | 100g | $76.9 |
| 1-(2-Chloroethyl)piperidine hydrochloride 98% | C42602 | 500g | $203 |
| 1-(2-Chloroethyl)piperidine Hydrochloride >98.0%(T) | C1073 | 25g | $55 |
| 1-(2-Chloroethyl)piperidine Hydrochloride >98.0%(T) | C1073 | 500g | $389 |
| 1-(2-Chloroethyl)piperidine hydrochloride Asreported | 269407 | 25g | $333 |
| More product size | |||
| Melting point | 230-232 °C(lit.) |
|---|---|
| Boiling point | 196 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Powder or Crystals |
| color | White to pale yellow to beige |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3910268 |
| InChI | InChI=1S/C7H14ClN.ClH/c8-4-7-9-5-2-1-3-6-9;/h1-7H2;1H |
| InChIKey | VFLQQZCRHPIGJU-UHFFFAOYSA-N |
| SMILES | N1(CCCl)CCCCC1.Cl |
| CAS DataBase Reference | 2008-75-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | P8KB8Z4ZTV |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H314 | |||||||||
| Precautionary statements | P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T+,Xi | |||||||||
| Risk Statements | 28-34-36/37/38 | |||||||||
| Safety Statements | 26-28-36/37/39-45-24/25 | |||||||||
| RIDADR | UN 2928 6.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TM6482500 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29333999 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 2 Oral Skin Corr. 1B |
|||||||||
| Toxicity | mouse,LD50,intraperitoneal,93mg/kg (93mg/kg),BEHAVIORAL: ATAXIA,Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948. | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
1-(2-Chloroethyl)piperidine hydrochloride price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C42602 | 1-(2-Chloroethyl)piperidine hydrochloride 98% | 2008-75-5 | 100g | $76.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | C42602 | 1-(2-Chloroethyl)piperidine hydrochloride 98% | 2008-75-5 | 500g | $203 | 2022-05-15 | Buy |
| TCI Chemical | C1073 | 1-(2-Chloroethyl)piperidine Hydrochloride >98.0%(T) | 2008-75-5 | 25g | $55 | 2026-04-30 | Buy |
| TCI Chemical | C1073 | 1-(2-Chloroethyl)piperidine Hydrochloride >98.0%(T) | 2008-75-5 | 500g | $389 | 2026-04-30 | Buy |
| Usbiological | 269407 | 1-(2-Chloroethyl)piperidine hydrochloride Asreported | 2008-75-5 | 25g | $333 | 2026-06-03 | Buy |
1-(2-Chloroethyl)piperidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Colorless to beige crystals
Uses
1-(2-Chloroethyl)piperidine hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. fenpiverinium bromide, cloperastine and pitofenone).
Uses
Hydrochloride salt of N-(β-Chloroethyl)piperidine is used in the inhibition of sickle-cell hemoglobin.
Synthesis
3040-44-6
2008-75-5
The general procedure for the synthesis of 1-(2-chloroethyl)piperidine hydrochloride using N-hydroxyethylpiperidine as starting material was as follows: N-hydroxyethylpiperidine (5 mL) was dissolved in chloroform (12.5 mL). Thionyl chloride (3.4 mL) was added slowly and dropwise under ice bath cooling conditions. The reaction mixture was slowly heated to reflux and the reflux reaction was maintained for 3 hours. Upon completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give a large crystalline precipitate. Finally, the product was purified by ethanol recrystallization to give 5.88 g of 1-(2-chloroethyl)piperidine hydrochloride in 85% yield.
References
[1] Patent: CN105884699, 2016, A. Location in patent: Paragraph 0048; 0049
[2] Patent: US2006/223855, 2006, A1. Location in patent: Page/Page column 160-161
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 5, p. 671 - 679
1-(2-Chloroethyl)piperidine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou uniringchem Co., Ltd. | 13585446801 | sales@uniringchem.com | China | 69 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3796 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 1-(2-Chloroethyl)piperidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2-Piperidinoethylchloride hydrochloride
2008-75-5
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 2-Piperidinoethylchloride hydrochloride
2008-75-5
- $1.00
- 98%
- Career Henan Chemical Co
1-(2-Chloroethyl)piperidine hydrochloride Spectrum
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