Pyrazine
- CAS No.
- 290-37-9
- Chemical Name:
- Pyrazine
- Synonyms
- Pyrazin;PyBO;Piazine;FEMA 4015;Paradiazine;1,4-Pyrazine;PYRAZINE;p-Diazine;1,4-DIAZINE;Pyrazine>
- CBNumber:
- CB1450659
- Molecular Formula:
- C4H4N2
Lewis structure
- Molecular Weight:
- 80.09
- MDL Number:
- MFCD00006122
- MOL File:
- 290-37-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pyrazine ≥99%, FG | W401501 | 1 each | $58 |
| Pyrazine ≥99%, FG | W401501 | 100g | $80 |
| Pyrazine ≥99%, FG | W401501 | 1kg | $395 |
| Pyrazine ≥99% | P56003 | 5g | $34.3 |
| Pyrazine for synthesis | 8.07064 | 100g | $230 |
| More product size | |||
| Melting point | 50-56 °C (lit.) |
|---|---|
| Boiling point | 115-116 °C (lit.) |
| Density | 1.031 g/mL at 25 °C (lit.) |
| refractive index | 1.5235 |
| FEMA | 4015 | PYRAZINE |
| FLAVIS Number | 14.144 | Pyrazine |
| Flash point | 132 °F |
| storage temp. | Store below +30°C. |
| solubility | SOLUBLE |
| pka | 0.65(at 27℃) |
| form | Crystals |
| Specific Gravity | 1.031 |
| color | White |
| Odor | at 0.10 % in propylene glycol. pungent sweet corn like roasted hazelnut barly |
| Odor Type | nutty |
| biological source | synthetic |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| Merck | 14,7957 |
| JECFA Number | 951 |
| BRN | 103905 |
| Dielectric constant | 2.7999999999999998 |
| Stability | Stable. Highly flammable. Incompatible with acids, oxidizing agents. |
| InChI | 1S/C4H4N2/c1-2-6-4-3-5-1/h1-4H |
| InChIKey | KYQCOXFCLRTKLS-UHFFFAOYSA-N |
| SMILES | c1cnccn1 |
| LogP | -0.26 |
| Substances Added to Food (formerly EAFUS) | PYRAZINE |
| CAS DataBase Reference | 290-37-9(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2JKE371789 |
| NIST Chemistry Reference | Pyrazine(290-37-9) |
| EPA Substance Registry System | Pyrazine (290-37-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228 | |||||||||
| Precautionary statements | P210-P240-P241-P280-P370+P378 | |||||||||
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38-11 | |||||||||
| Safety Statements | 26-36-16 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ2015000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Flam. Sol. 1 | |||||||||
| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Pyrazine price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W401501 | Pyrazine ≥99%, FG | 290-37-9 | 1 each | $58 | 2026-04-30 | Buy |
| Sigma-Aldrich | W401501 | Pyrazine ≥99%, FG | 290-37-9 | 100g | $80 | 2026-04-30 | Buy |
| Sigma-Aldrich | W401501 | Pyrazine ≥99%, FG | 290-37-9 | 1kg | $395 | 2026-04-30 | Buy |
| Sigma-Aldrich | P56003 | Pyrazine ≥99% | 290-37-9 | 5g | $34.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.07064 | Pyrazine for synthesis | 290-37-9 | 100g | $230 | 2026-04-30 | Buy |
Pyrazine Chemical Properties,Uses,Production
Description
Pyrazine is a heterocyclic aromatic organic compound and can be reacted to obtain diverse pyrazine derivatives. Pyrazines are important contributors to the flavor of various roasted, toasted, or similarly heated foods. Pyrazine derivatives exhibit a wide variety of aromas in food, e.g. 2-methoxy-3-isopropylpyrazine produces a green pea odor. Pyrazines and pyrazine derivatives are typically used as flavor agent. Pyrazines and Pyrazine derivatives are also used as fragrances.
References
[1] T.B. Adamsa, J. Doullb, V.J. Feronc, J.I. Goodmand, L.J. Marnette, I.C. Munrof, P.M. Newberneg, P.S. Portogheseh, R.L. Smithi, W.J. Waddellj and B.M. Wagnerk, The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients, Food and Chemical Toxicology, 2002, vol. 40, 429-451
Chemical Properties
white crystals or powder
Chemical Properties
Pyrazine has a strong pyridine-like odor. Some reports compare the taste of pyrazine to cooked spinach or rancid peanuts
Occurrence
Pyrazine has been detected in several food products including papayas, asparagus, peanuts, popcorn, soybeans, corn, French fries, bread, cheese, milk, eggs (boiled), chicken (fried), beef (cooked), shrimp, clams, beer, sherry, malt, coffee and tea (green).
Uses
Pyrazine is used as a flavoring agent. It serves as a component of some herbs in traditional Chinese medicine. It is employed as pharmaceutical intermediates, perfume intermediates and involved in the preparation of other chemicals. In addition to this, it is used in the production of pyrazine 1-oxide.
Preparation
Prepared by cyclization of α-amino ketones, which were produced by the reduction of isonitroso ketones to yield the dihydropyrazines, which are dehydrogenated with mercury(I) oxide or copper(II) sulfate or sometimes with atmospheric oxygen.
Definition
pyrazine: An unsaturated heterocycliccompound having two nitrogenatoms in a six-membered ring,C4H4N2; r.d. 1.03; m.p. 52°C; b.p.115°C. Pyrazine is a symmetric diazine.
Definition
A heterocyclic aromatic compound with a six-membered ring containing four carbon atoms and two nitrogen atoms.
Definition
ChEBI: A diazine that is benzene in which the carbon atoms at positions 1 and 4 have been replaced by nitrogen atoms.
Aroma threshold values
300 ppm (odor threshold in water)
General Description
Pyrazine is a 1,4-diazine and an electron-deficient N-heteroarene found in several natural products, APIs, agrochemicals, and functional materials.
Purification Methods
Distil pyrazine in steam and crystallise it from water. Purify also by zone melting. [Beilstein 23 H 91, 23 II 80, 23 III/IV 899, 23/5 V 351.]
Pyrazine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2988 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
Related articles
- Pyrazine: Aromatic Heterocycle
- Pyrazine is a para-dinitrogen six-membered aromatic heterocycle with nutty roasted aroma, widely applied as food flavor additi....
- Jun 22，2026
View Lastest Price from Pyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-24 | Pyrazine
290-37-9
|
$2.00 | 1KG | 99% | 200mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2026-07-09 | Pyrazine
290-37-9
|
$1.10-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
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2026-06-30 | Pyrazine
290-37-9
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
