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ChemicalBook >> CAS DataBase List >>N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE

CAS No.
147795-39-9
Chemical Name:
N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE
Synonyms
3-oxo-C8-HSL;N-(β-Ketooctanoyl)-L-homoserine;N-(3-Oxooctanoyl)-L-homoserine la;3-oxo-N-[(3S)-2-oxooxolan-3-yl]octanamide;N-(beta-oxooctan-1-oyl)homoserine lactone;N-(beta-Oxooctan-1-oyl)-L-homoserine lactone;(S)-3-oxo-N-(2-oxotetrahydrofuran-3-yl)octanaMide;(S)-4-Oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide;N-3-Oxo-octanoyl-L-homoserine lactone, 10 mM in DMSO;Octanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
CBNumber:
CB1504055
Molecular Formula:
C12H19NO4
Molecular Weight:
241.28
MDL Number:
MFCD08277025
MOL File:
147795-39-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 11:24:09
Product description Number Pack Size Price
N-(3-Oxooctanoyl)-L-homoserine lactone ≥97% (HPLC), white powder O1764 10mg $97.8
N-(3-Oxooctanoyl)-L-homoserine lactone ≥97% (HPLC), white powder O1764 100mg $451
N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 10011206 5mg $42
N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 10011206 10mg $73
N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 10011206 25mg $169

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Properties

Melting point 54-60 °C
Boiling point 490.1±45.0 °C(Predicted)
Density 1.12±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility chloroform: 50 mg/mL, clear, colorless
form white powder
pka 11.09±0.46(Predicted)
color White to off-white
InChI 1S/C12H19NO4/c1-2-3-4-5-9(14)8-11(15)13-10-6-7-17-12(10)16/h10H,2-8H2,1H3,(H,13,15)/t10-/m0/s1
InChIKey FXCMGCFNLNFLSH-JTQLQIEISA-N
SMILES CCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
UNSPSC Code 12352202
NACRES NA.32

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O1764 N-(3-Oxooctanoyl)-L-homoserine lactone ≥97% (HPLC), white powder 147795-39-9 10mg $97.8 2026-04-30 Buy
Sigma-Aldrich O1764 N-(3-Oxooctanoyl)-L-homoserine lactone ≥97% (HPLC), white powder 147795-39-9 100mg $451 2026-04-30 Buy
Cayman Chemical 10011206 N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 147795-39-9 5mg $42 2026-04-30 Buy
Cayman Chemical 10011206 N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 147795-39-9 10mg $73 2026-04-30 Buy
Cayman Chemical 10011206 N-3-oxo-octanoyl-L-Homoserine lactone ≥98% 147795-39-9 25mg $169 2026-04-30 Buy
Product number Packaging Price Buy
O1764 10mg $97.8 Buy
O1764 100mg $451 Buy
10011206 5mg $42 Buy
10011206 10mg $73 Buy
10011206 25mg $169 Buy

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Chemical Properties,Uses,Production

Description

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). Regulation of bacterial quorum sensing signaling systems to inhibit pathogenesis represents a new approach to antimicrobial therapy in the treatment of infectious diseases. AHLs vary in acyl group length (C4-C18), in the substitution of C3 (hydrogen, hydroxyl, or oxo group), and in the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. In the gram-negative bacterium A. tumefaciens, N-3-oxo-octanoyl-L-homoserine lactone promotes the expression of the transcriptional activator (and LuxR homolog) TraR.

Uses

N-3-oxo-octanoyl-L-Homoserine lactone is a reagent that promotes the expression of the transcriptional activator.

Uses

N-(3-Oxooctanoyl)-L-homoserine lactone has been used to study the effects of pH, temperature and salinity on extracellular polymeric substances (EPS) of Pseudomonas aeruginosa biofilm.

General Description

N-(3-Oxooctanoyl)-L-homoserine lactone is a common quorum sensing (QS) signal.

Biochem/physiol Actions

N-(3-Oxooctanoyl)-L-homoserine lactone stimulates the tra gene expression. It is an autoinducer and potent antagonist.

References

[1] JUAN E GONZáLEZ N D K. Messing with bacterial quorum sensing.[J]. Microbiology and Molecular Biology Reviews, 2006, 70 4: 859-875. DOI: 10.1128/mmbr.00002-06
[2] TY A GOULD. Specificity of acyl-homoserine lactone synthases examined by mass spectrometry.[J]. Journal of Bacteriology, 2006, 188 2: 773-783. DOI: 10.1128/jb.188.2.773-783.2006
[3] LYNETTE CEGELSKI. The biology and future prospects of antivirulence therapies[J]. Nature Reviews Microbiology, 2008, 6 1: 17-27. DOI: 10.1038/nrmicro1818
[4] CARLOS G. NIETO PENALVER . Methylobacterium extorquens AM1 produces a novel type of acyl-homoserine lactone with a double unsaturated side chain under methylotrophic growth conditions[J]. FEBS Letters, 2006, 580 2: Pages 561-567. DOI: 10.1016/j.febslet.2005.12.062
[5] J ZHU. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens.[J]. Journal of Bacteriology, 1998, 180 20: 5398-5405. DOI: 10.1128/jb.180.20.5398-5405.1998

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Suppliers

Global( 62)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39037 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Shanghai Hanhong Scientific Co., Ltd. 		+undefined17612118332 Lucky@hanhonggroup.com China 5844 58
pinkeyan 4000-685-696 17713219769 pinkeyan@163.com China 500 58
Syntechem Co.,Ltd info@syntechem.com China 12984 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7237 62

View Lastest Price from N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-3-Oxo-octanoyl-L-homoserine lactone pictures 2026-06-02 N-3-Oxo-octanoyl-L-homoserine lactone
147795-39-9
 $40.00-139.00 98.00% 10g TargetMol Chemicals Inc.

N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE Spectrum

N-(beta-Oxooctan-1-oyl)-L-homoserine lactone N-(beta-oxooctan-1-oyl)homoserine lactone N-(β-Ketooctanoyl)-L-homoserine (S)-3-oxo-N-(2-oxotetrahydrofuran-3-yl)octanaMide Octanamide, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]- 3-oxo-N-[(3S)-2-oxooxolan-3-yl]octanamide N-(3-Oxooctanoyl)-L-homoserine la inhibit,signal,Agrobacterium,Inhibitor,N 3 Oxo octanoyl L homoserine lactone,quorum-sensing,N3OxooctanoylLhomoserine lactone (S)-4-Oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide (S)-4-Oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide , N-3-Oxo-octanoyl-L-homoserine lactone N-3-Oxo-octanoyl-L-homoserine lactone, 10 mM in DMSO 3-oxo-C8-HSL 147795-39-9
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