BCL2L10 antibody
- CAS No.
- Chemical Name:
- BCL2L10 antibody
- Synonyms
- BCL2L10 antibody;Mouse Monoclonal BCL2L10 Antibody
- CBNumber:
- CB15607540
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| BCL2L10 antibody Affinity purified by Protein A | orb101255 | 100μg | $402.9 |
| BCL2L10 antibody | orb73685 | 100μL | $584.8 |
| BCL2L10 antibody Affinity purified by Protein A | orb101255 | 200μg | $654.5 |
BCL2L10 antibody price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biorbyt Ltd | orb101255 | BCL2L10 antibody Affinity purified by Protein A | 100μg | $402.9 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb73685 | BCL2L10 antibody | 100μL | $584.8 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb101255 | BCL2L10 antibody Affinity purified by Protein A | 200μg | $654.5 | 2021-12-16 | Buy |
BCL2L10 antibody Chemical Properties,Uses,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
The Bcl-2 family consists of a number of evolutionarily conserved proteins containing Bcl-2 homology domains that regulate apoptosis through control of mitochondrial membrane permeability and release of cytochrome c. Four BH domains have been identified that mediate protein interactions. The family can be separated into three groups based upon function and sequence homology: pro-survival members include Bcl-2, Bcl-xL, Mcl-1, A1 and Bcl-w; pro-apoptotic proteins include Bax, Bak and Bok; and "BH3 only" proteins Bad, Bik, Bid, Puma, Bim, Bmf, Noxa and Hrk. Interactions between death-promoting and death-suppressing Bcl-2 family members has led to a rheostat model in which the ratio of pro-apoptotic and anti-apoptotic proteins controls cell fate. Thus, pro-survival members exert their behavior by binding to and antagonizing death-promoting members. In general, the "BH3-only members" can bind to and antagonize the pro-survival proteins leading to increased apoptosis. While some redundancy of this system likely exists, tissue specificity, transcriptional and post-translational regulation of many of these family members can account for distinct physiological roles.Bcl-2-like 10, known as Diva or Boo in mouse and Bcl-B in human, is a Bcl-2 family member with some unique properties. Expression of the mouse mRNA was detected in multiple embryonic tissues but restricted to adult ovary and testis; human Bcl-B appears to be more widely expressed. BCL2L10 contains BH1, 2, and 4 domains as well as a putative carboxy-terminal transmembrane domain. While some studies report the presence of a pro-apoptotic BH3 domain in BCL2L10, conflicting reports indicate an incomplete or absent BH3 domain. Similarly, some studies indicate that BCL2L10 induces apoptosis while other data implies a role in suppressing cell death. BCL2L10 may function by differentially binding other Bcl-2 family members and through interaction with the apoptosome protein Apaf-1. Despite its restricted expression in mice, Diva knockouts were fertile and exhibit no obvious developmental defects.
References
[1] Cory, S. et al. (2003) Oncogene 22, 8590-607.
[2] Antonsson, B. and Martinou, J.C. (2000) Exp Cell Res 256, 50-7.
[3] Sharpe, J.C. et al. (2004) Biochim Biophys Acta 1644, 107-13.
[4] Korsmeyer, S.J. et al. (1993) Semin Cancer Biol 4, 327-32.
[5] Bouillet, P. and Strasser, A. (2002) J Cell Sci 115, 1567-74.
[6] Inohara, N. et al. (1998) J Biol Chem 273, 32479-86.
[7] Song, Q. et al. (1999) EMBO J 18, 167-78.
[8] Ke, N. et al. (2001) J Biol Chem 276, 12481-4.
[9] Lee, R. et al. (2001) Biochim Biophys Acta 1520, 187-94.
[10] Naumann, U. et al. (2001) FEBS Lett 505, 23-6.
BCL2L10 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
BCL2L10 antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Ipodix Biotechnology Co.,Ltd. | 18007124176 19384116026 | 2706668885@qq.com | China | 4987 | 58 |
| Hubei Serenity BioSolutions Co., Ltd. | 027-19371278702 18008634902 | 19384116026@163.com | China | 3008 | 58 |
| GeneTex, Inc. | -- | international@genetex.com | China | 6092 | 58 |
| Biosynth Ltd | -- | sales@biosynth.com | China | 6218 | 58 |
| Cell Signaling Technology Inc | -- | info@cellsignal.cn | China | 6725 | 58 |
| Abmart Inc | -- | market@ab-mart.com | China | 6917 | 58 |
| Wuhan Fine Biotech Co Ltd | -- | marketing@fn-test.com | China | 6600 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | -- | sales@biosynth.com | China | 6051 | 58 |
| Rockland Immunochemicals Inc | -- | antibodies-onlinename@qq.com | China | 6808 | 58 |
| Shanghai Tuoran Biotechnology Co., Ltd. | -- | CHINA | 5067 | 58 |
