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p53 (7F5) Rabbit mAb (Biotinylated)

CAS No.
Chemical Name:
p53 (7F5) Rabbit mAb (Biotinylated)
Synonyms
p53 (7F5) Rabbit mAb (Biotinylated)
CBNumber:
CB15669663
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

p53 (7F5) Rabbit mAb (Biotinylated) Chemical Properties,Uses,Production

Description

This antibody is conjugated to biotin under optimal conditions.

Source

Rabbit

Reactivity

Human;Monkey

Background

The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. Activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced interaction between p53 and its negative regulator, the oncoprotein MDM2. MDM2 inhibits p53 accumulation by targeting it for ubiquitination and proteasomal degradation. p53 can be phosphorylated by ATM, ATR, and DNA-PK at Ser15 and Ser37. Phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and activation of p53 in response to DNA damage. Chk2 and Chk1 can phosphorylate p53 at Ser20, enhancing its tetramerization, stability, and activity. p53 is phosphorylated at Ser392 in vivo and by CAK in vitro. Phosphorylation of p53 at Ser392 is increased in human tumors and has been reported to influence the growth suppressor function, DNA binding, and transcriptional activation of p53. p53 is phosphorylated at Ser6 and Ser9 by CK1δ and CK1ε both in vitro and in vivo. Phosphorylation of p53 at Ser46 regulates the ability of p53 to induce apoptosis. Acetylation of p53 is mediated by p300 and CBP acetyltransferases. Inhibition of deacetylation suppressing MDM2 from recruiting HDAC1 complex by p19 stabilizes p53. Acetylation appears to play a positive role in the accumulation of p53 protein in stress response. Following DNA damage, human p53 becomes acetylated at Lys382 in vivo to enhance p53-DNA binding. Deacetylation of p53 occurs through interaction with the SIRT1 protein, a deacetylase that may be involved in cellular aging and the DNA damage response.

References

[1] Levine, A.J. (1997) Cell 88, 323-31.
[2] Meek, D.W. (1994) Semin Cancer Biol 5, 203-10.
[3] Milczarek, G.J. et al. (1997) Life Sci 60, 1-11.
[4] Shieh, S.Y. et al. (1997) Cell 91, 325-34.
[5] Chehab, N.H. et al. (1999) Proc Natl Acad Sci U S A 96, 13777-82.
[6] Honda, R. et al. (1997) FEBS Lett 420, 25-7.
[7] Tibbetts, R.S. et al. (1999) Genes Dev 13, 152-7.
[8] Shieh, S.Y. et al. (1999) EMBO J 18, 1815-23.
[9] Hirao, A. et al. (2000) Science 287, 1824-7.
[10] Hao, M. et al. (1996) J Biol Chem 271, 29380-5.

p53 (7F5) Rabbit mAb (Biotinylated) Preparation Products And Raw materials

Raw materials

Preparation Products

p53 (7F5) Rabbit mAb (Biotinylated) Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Beijing Dongling Technology Co., Ltd. 13051591126 CHINA 6726 58
Shanghai Haoye Biotechnology Co., Ltd. 15121098156 CHINA 6534 58
p53 (7F5) Rabbit mAb (Biotinylated)
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