Source

Rabbit

Reactivity

Human;Mouse

Background

The centrosome is composed of a pair of centrioles surrounded by electron-dense pericentriolar material and functions as the microtubule-organizing center responsible for microtubule nucleation and spindle organization during cell cycle progression. Pericentriolar material 1 is a large, 228 kDa protein associated with the centrosome in a cell cycle-dependent manner. PCM-1 localizes to small cytoplasmic granules called centriolar satellites. PCM-1 is required for the assembly of several centrosomal proteins, including centrin, pericentrin, ninein, NEK2, and CEP250. Chromosomal translocations involving genes encoding PCM-1 and the tyrosine kinases Ret and Jak2 are associated with some cancers, including papillary thyroid carcinoma and myeloid leukemia.

References

[1] Zimmerman, W. and Doxsey, S.J. (2000) Traffic 1, 927-34.
[2] Balczon, R. et al. (1994) J Cell Biol 124, 783-93.
[3] Kubo, A. and Tsukita, S. (2003) J Cell Sci 116, 919-28.
[4] Kim, J. et al. (2008) Hum Mol Genet 17, 3796-805.
[5] Dammermann, A. and Merdes, A. (2002) J Cell Biol 159, 255-66.
[6] Li, Q. et al. (2001) J Cell Sci 114, 797-809.
[7] Hames, R.S. et al. (2005) Mol Biol Cell 16, 1711-24.
[8] Mack, G.J. et al. (1998) Arthritis Rheum 41, 551-8.
[9] Corvi, R. et al. (2000) Oncogene 19, 4236-42.
[10] Reiter, A. et al. (2005) Cancer Res 65, 2662-7.

Raw materials

Preparation Products