Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

GTPase Regulator Associated with Focal Adhesion Kinase-1, is a GTPase-activating protein for the small G proteins RhoA and Cdc42. It is composed of an N-terminal BAR domain, a PH domain, a RhoGAP domain, a proline-rich domain, and a C-terminal SH3 domain. GRAF1 contributes to the clathrin-independent carriers/GPI-enriched early endosomal compartments pathway, and was the first specific protein component of this endocytic pathway to be discovered. GRAF1 was identified as an important protein necessary for adeno-associated virus 2 infection. In addition, research studies have linked GRAF1 to mental retardation, skeletal muscle differentiation, and myeloid leukemia.

References

[1] Hildebrand, J.D. et al. (1996) Mol Cell Biol 16, 3169-78.
[2] Lundmark, R. et al. (2008) Curr Biol 18, 1802-8.
[3] Nonnenmacher, M. and Weber, T. (2011) Cell Host Microbe 10, 563-76.
[4] Barresi, V. et al. (2010) BMC Med Genomics 3, 28.
[5] Doherty, J.T. et al. (2011) J Biol Chem 286, 25903-21.
[6] Qian, J. et al. (2011) Leuk Res 35, 783-6.
[7] Qian, Z. et al. (2010) J Exp Clin Cancer Res 29, 111.

Raw materials

Preparation Products