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PLK2 (D5R2B) Rabbit mAb

CAS No.
Chemical Name:
PLK2 (D5R2B) Rabbit mAb
Synonyms
PLK2 (D5R2B) Rabbit mAb
CBNumber:
CB16277823
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

PLK2 (D5R2B) Rabbit mAb Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human

Background

At least five distinct polo-like kinases exist in mammalian cells: PLK1, PLK2, PLK3, PLK4/SAK, and the non-catalytic PLK5 protein. The p53-induced PLK2 functions in centriole duplication, as well as at spindle and S phase checkpoints. Research studies show that PLK2 expression is related to chemosensitivity in ovarian cancer. Downregulation of PLK2 expression in chemosensitive ovarian cancer cells is associated with a greater chance of relapse in patients following specific treatment regimens. PLK2 can phosphorylate α-synuclein at Ser129, which is a site shown to be involved in diseases of the central nervous system. Polo-like kinase 2 also phosphorylates GEFs and GAPs, regulating Ras and Rap small GTPase function in neurons.

References

[1] de Cárcer, G. et al. (2011) Cell Cycle 10, 2255-62.
[2] Cizmecioglu, O. et al. (2008) Cell Cycle 7, 3548-55.
[3] Burns, T.F. et al. (2003) Mol Cell Biol 23, 5556-71.
[4] Matthew, E.M. et al. (2007) Cell Cycle 6, 2571-8.
[5] Cizmecioglu, O. et al. (2012) J Cell Sci 125, 981-92.
[6] Syed, N. et al. (2011) Cancer Res 71, 3317-327.
[7] Inglis, K.J. et al. (2009) J Biol Chem 284, 2598-602.
[8] Bergeron, M. et al. (2014) Neuroscience 256, 72-82.
[9] Lee, K.J. et al. (2011) Neuron 69, 957-73.

PLK2 (D5R2B) Rabbit mAb Preparation Products And Raw materials

Raw materials

Preparation Products

PLK2 (D5R2B) Rabbit mAb Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Hangzhou Novas Biotechnology Co., Ltd. 15264006066 CHINA 1844 58
Shanghai Tuoran Biotechnology Co., Ltd. 18621916228 CHINA 5067 58
PLK2 (D5R2B) Rabbit mAb
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