N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
- CAS No.
- 13880-05-2
- Chemical Name:
- N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
- Synonyms
- N-[TRIS(HYDROXYMETHYL)METHYL]ACRYLAMIDE;NAT, TRIS-acrylamide;N-[Tris(hydroxymethyL;ACRYLAMIDOTRISHYDROXYMETHYLMETHANE;N-(1,3-Dihydroxy-2-(hydroxymethyl);Acryloylaminomethylidynetrimethanol;N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE;N-acryloyl (trihydroxymethyl) aminomethane;N-[Tris(hydroxymethyl)methyl]acrylamide,98%;2-ACRYLAMIDO-2-HYDROXYMETHYL-1,3-PROPANEDIOL
- CBNumber:
- CB1753970
- Molecular Formula:
- C7H13NO4
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD00081045
- MOL File:
- 13880-05-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| N-[Tris(hydroxymethyl)methyl]acrylamide contains ≤7% KCl, 93% | 364959 | 5g | $86.8 |
| N-[Tris(hydroxymethyl)methyl]acrylamide contains ≤7% KCl, 93% | 364959 | 25g | $416 |
| N-Acryloyltris(hydroxymethyl)aminomethane | 146574 | 5.00g | $65 |
| N-Acryloyltris(hydroxymethyl)aminomethane | 146574 | 25.00g | $215 |
| N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide 97% | AA0019IK | 1g | $23 |
| More product size | |||
| Melting point | 136-141 °C(lit.) |
|---|---|
| Boiling point | 510.8±50.0 °C(Predicted) |
| Density | 1.272±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 12.74±0.46(Predicted) |
| Water Solubility | Soluble in water. |
| Sensitive | Light Sensitive & Hygroscopic |
| BRN | 2081162 |
| InChI | InChI=1S/C7H13NO4/c1-2-6(12)8-7(3-9,4-10)5-11/h2,9-11H,1,3-5H2,(H,8,12) |
| InChIKey | MVBJSQCJPSRKSW-UHFFFAOYSA-N |
| SMILES | C(NC(CO)(CO)CO)(=O)C=C |
| CAS DataBase Reference | 13880-05-2(CAS DataBase Reference) |
| FDA UNII | R8VGY8CVF2 |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| HS Code | 29241900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 364959 | N-[Tris(hydroxymethyl)methyl]acrylamide contains ≤7% KCl, 93% | 13880-05-2 | 5g | $86.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 364959 | N-[Tris(hydroxymethyl)methyl]acrylamide contains ≤7% KCl, 93% | 13880-05-2 | 25g | $416 | 2026-04-30 | Buy |
| Matrix Scientific | 146574 | N-Acryloyltris(hydroxymethyl)aminomethane | 13880-05-2 | 5.00g | $65 | 2026-05-18 | Buy |
| Matrix Scientific | 146574 | N-Acryloyltris(hydroxymethyl)aminomethane | 13880-05-2 | 25.00g | $215 | 2026-05-18 | Buy |
| aablocks | AA0019IK | N-(1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl)acrylamide 97% | 13880-05-2 | 1g | $23 | 2026-05-28 | Buy |
N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Chemical Properties,Uses,Production
Chemical Properties
White crystals or crystalline powder
Uses
N-[Tris(hydroxymethyl)methyl] acrylamide is used to prepare N-(5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)-acrylamide by reaction with benzaldehyde.
Synthesis
814-68-6
77-86-1
13880-05-2
N-Acryloyl(tris(hydroxymethyl)aminomethane was synthesized from acryloyl chloride and tris(hydroxymethyl)aminomethane according to the method reported by Pucci et al. (Eur. Polym. J. 1991, 27, 1101). The procedure was as follows: to a stirred 3N potassium hydroxide methanol solution of tris(hydroxymethyl)aminomethane (3.00 g, 24.8 mmol), acryloyl chloride (3.60 mL, 44.6 mmol) was added slowly and dropwise at 0 °C, keeping the pH of the reaction system between 8 and 8. The reaction mixture was continued to be stirred at 0 °C for 3 h. The reaction was then naturally warmed to room temperature and continued for 4 h. The reaction was carried out at 0 °C. After completion of the reaction, the mixture was filtered and the filtrate was evaporated to dryness under vacuum. The resulting solid was purified by recrystallization from methanol to afford the target compound, N-acryloyl(trimethylol)aminomethane (3.78 g, 87%), as a white powder with a melting point of 205 °C. The product was purified by recrystallization from methanol. The product was characterized by the following data: IR (NaCl, cm^-1): 3420 (br, s), 1653 (s), 1560 (m), 1540 (m), 1018 (m); 1H NMR (300 MHz, DMSO-d6): δ 3.56 (d, 6H, J = 5.7 Hz, CH2), 4.76 (t, 3H, J = 5.7 Hz, OH), 5.54 (dd, 1H, J = 2.4, 9.9 Hz, Ha), 6.02 (dd, 1H, J = 2.4, 17.1 Hz, Hb), 6.37 (dd, 1H, J = 9.9, 17.1 Hz, Hc), 7.42 (s, 1H, NH).
References
[1] Journal of Organic Chemistry, 2008, vol. 73, # 14, p. 5602 - 5605
[2] Patent: WO2016/185425, 2016, A1. Location in patent: Page/Page column 57
[3] Macromolecular Bioscience, 2013, vol. 13, # 4, p. 512 - 522
[4] Tetrahedron, 2001, vol. 57, # 50, p. 9979 - 9987
[5] Tetrahedron Letters, 1991, vol. 32, # 11, p. 1437 - 1440
N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16511 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
View Lastest Price from N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
13880-05-2
|
$2.00-5.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
![N-[Tris(hydroxymethyl)methyl]acrylamide pictures](/ProductImageEN/2022-09/Small/1959e134-fad8-4120-ae06-1453d4075895.png) |
2025-04-04 | N-[Tris(hydroxymethyl)methyl]acrylamide
13880-05-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- N-ACRYLOYLTRIS(HYDROXYMETHYL)AMINOMETHANE
13880-05-2
- $2.00-5.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- N-[Tris(hydroxymethyl)methyl]acrylamide
13880-05-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
