5-Bromo-8-nitroisoquinoline
- CAS No.
- 63927-23-1
- Chemical Name:
- 5-Bromo-8-nitroisoquinoline
- Synonyms
- 5-BROMO-8-NITROISOQUINOLINE;5-BroMo-8-nitroisoquinolilne;Isoquinoline, 5-bromo-8-nitro-;5-Bromo-8-nitroisoquinoline >5-Bromo-8-nitroisoquinoline 90%;5-Bromo-8-nitroisoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB1779655
- Molecular Formula:
- C9H5BrN2O2
- Molecular Weight:
- 253.05
- MDL Number:
- MFCD02091227
- MOL File:
- 63927-23-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Bromo-8-nitroisoquinoline 90% | 675148 | 1g | $51.9 |
| 5-Bromo-8-nitroisoquinoline >98.0%(GC)(T) | B4163 | 1g | $68 |
| 5-Bromo-8-nitroisoquinoline >97% | OR41003 | 5g | $21 |
| 5-Bromo-8-nitroisoquinoline >97% | OR41003 | 25g | $67 |
| 5-Bromo-8-nitroisoquinoline >97% | OR41003 | 100g | $243 |
| More product size | |||
| Melting point | 136-140 °C |
|---|---|
| Boiling point | 386.9±27.0 °C(Predicted) |
| Density | 1.747±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 2+-.0.36(Predicted) |
| color | Light yellow to Yellow to Orange |
| InChI | 1S/C9H5BrN2O2/c10-8-1-2-9(12(13)14)7-5-11-4-3-6(7)8/h1-5H |
| InChIKey | ULGOLOXWHJEZNZ-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ccc(Br)c2ccncc12 |
| CAS DataBase Reference | 63927-23-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H318 |
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 |
| Hazard Codes | T |
| Risk Statements | 25-37/38-41 |
| Safety Statements | 26-39-45 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| HS Code | 2933499090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Irrit. 2 |
5-Bromo-8-nitroisoquinoline price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 675148 | 5-Bromo-8-nitroisoquinoline 90% | 63927-23-1 | 1g | $51.9 | 2023-01-07 | Buy |
| TCI Chemical | B4163 | 5-Bromo-8-nitroisoquinoline >98.0%(GC)(T) | 63927-23-1 | 1g | $68 | 2026-04-30 | Buy |
| Apolloscientific | OR41003 | 5-Bromo-8-nitroisoquinoline >97% | 63927-23-1 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR41003 | 5-Bromo-8-nitroisoquinoline >97% | 63927-23-1 | 25g | $67 | 2026-06-04 | Buy |
| Apolloscientific | OR41003 | 5-Bromo-8-nitroisoquinoline >97% | 63927-23-1 | 100g | $243 | 2026-06-04 | Buy |
5-Bromo-8-nitroisoquinoline Chemical Properties,Uses,Production
Uses
5-Bromo-8-nitroisoquinoline is mainly used as an intermediate in organic synthesis and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, pesticides, and dyes. In organic synthesis transformations, the bromine atom in 5-bromo-8-nitroisoquinoline can undergo debromination and hydrochemical oxidation under palladium and hydrogen conditions; in addition, the nitrogen atom on the isoquinoline ring can be oxidized to nitrogen oxides under the action of appropriate oxidizing agents.
Chemical Properties
It is light yellow solid powder under normal temperature and pressure, with certain alkalinity, can form salt with various acids.
Synthesis
34784-04-8
63927-23-1
Example 2: An aqueous solution of potassium nitrate (1.78 g, 8.56 mmol) was slowly added dropwise to a solution of 5-bromoisoquinoline dissolved in 12 mL of concentrated sulfuric acid. The reaction mixture was stirred at room temperature for 3 hours before it was poured into ice water and neutralized with concentrated ammonium hydroxide solution. The resulting yellow precipitate was extracted by ethyl acetate (3 x 10 mL) and the combined organic layers were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration, the organic phase was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography to afford 5-bromo-8-nitroisoquinoline in 96% yield using a hexane solution of 40% ethyl acetate as eluent.
References
[1] Patent: WO2004/76424, 2004, A1. Location in patent: Page 174-175
[2] Patent: EP698025, 1997, B1
[3] Patent: US5917053, 1999, A
[4] Patent: US5436250, 1995, A
[5] Patent: EP633262, 1995, A1
5-Bromo-8-nitroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29094 | 58 |
| Aston Chemical | -- | sales@astonchem.com | United States | 1634 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
View Lastest Price from 5-Bromo-8-nitroisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 5-Bromo-8-nitroisoquinoline
63927-23-1
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-07-06 | 5-Bromo-8-nitroisoquinoline
63927-23-1
|
$8.00 | 1KG | 99% | 10tons | Career Henan Chemical Co |
-
- 5-Bromo-8-nitroisoquinoline
63927-23-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromo-8-nitroisoquinoline
63927-23-1
- $8.00
- 99%
- Career Henan Chemical Co
