2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- CAS No.
- 154675-18-0
- Chemical Name:
- 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
- Synonyms
- Hhbpdde;HBDDE, PKCalpha and PKCgamma inhibitor;[1,1'-Biphenyl]-2,2',3,3',4,4'-hexol, 6,6'-bis(methoxymethyl)-
- CBNumber:
- CB21355051
- Molecular Formula:
- C16H18O8
- Molecular Weight:
- 338.31
- MDL Number:
- MFCD00925616
- MOL File:
- 154675-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| HBDDE - CAS 154675-18-0 - Calbiochem A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays. | 372770 | 1MG | $255 |
| HBDDE 98.03% | CS-0132740 | 1mg | $390 |
| HBDDE 98.03% | CS-0132740 | 5mg | $953 |
| HBDDE 98.03% | CS-0132740 | 10mg | $1300 |
| HBDDE 98.03% | CS-0132740 | 1mg | $390 |
| Melting point | 165-168℃ |
|---|---|
| storage temp. | -20°C |
| solubility |
ethanol: 1mg/mL warm water: 1mg/mL DMSO: 5mg/mL |
| form | Orange solid. |
| color | Brown to khaki |
| Sensitive | Light Sensitive |
| InChI | 1S/C16H18O8/c1-23-5-7-3-9(17)13(19)15(21)11(7)12-8(6-24-2)4-10(18)14(20)16(12)22/h3-4,17-22H,5-6H2,1-2H3 |
| InChIKey | NEBCAMAQXZIVRE-UHFFFAOYSA-N |
| SMILES | O(Cc1c(c(c(c(c1)O)O)O)c2c(c(c(cc2COC)O)O)O)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 372770 | HBDDE - CAS 154675-18-0 - Calbiochem A cell-permeable protein kinase C (PKC) inhibitor that selectively inhibits PKC&alpha and PKCγ over PKCδ, βI, and βII isozymes in in vitro assays. | 154675-18-0 | 1MG | $255 | 2026-04-30 | Buy |
| ChemScene | CS-0132740 | HBDDE 98.03% | 154675-18-0 | 1mg | $390 | 2026-06-04 | Buy |
| ChemScene | CS-0132740 | HBDDE 98.03% | 154675-18-0 | 5mg | $953 | 2026-06-04 | Buy |
| ChemScene | CS-0132740 | HBDDE 98.03% | 154675-18-0 | 10mg | $1300 | 2026-06-04 | Buy |
| ChemScene | CS-0132740 | HBDDE 98.03% | 154675-18-0 | 1mg | $390 | 2026-06-04 | Buy |
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Chemical Properties,Uses,Production
Uses
HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
Definition
ChEBI: 5-(methoxymethyl)-4-[2,3,4-trihydroxy-6-(methoxymethyl)phenyl]benzene-1,2,3-triol is a tannin.
Biological Activity
Cell permeable: yes', 'Primary Target
PKCα', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 43 μM against PKCα
IC 50
PKCα: 43 μM (IC50); PKCγ: 50 μM (IC50)
References
[1] A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. DOI:10.1016/s0006-2952(00)00398-1
[2] Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200. DOI:10.1021/jm00027a025
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Preparation Products And Raw materials
Raw materials
Preparation Products
2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29757 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24955 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | -- | Sales@sangon.com | China | 6710 | 58 |
| Enzo Biochem Inc | -- | Enzoname@qq.com | China | 6174 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6394 | 58 |
