N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
![N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Structure](CAS/GIF/178870-32-1.gif)
- CAS No.
- 178870-32-1
- Chemical Name:
- N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide
- Synonyms
- Nsc675186;Aids029940;Aids-029940;Thiocarboxanilide;N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide;N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide;3-Furancarbothioamide, N-[4-chloro-3-[(3-methyl-2-buten-1-yl)oxy]phenyl]-2-methyl-
- CBNumber:
- CB21455999
- Molecular Formula:
- C17H18ClNO2S
- Molecular Weight:
- 335.85
- MDL Number:
- MFCD00952139
- MOL File:
- 178870-32-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| UC-781 | BA1974 | 1mg | $205 |
| N-(4-Chloro-3-((3-methylbut-2-en-1-yl)oxy)phenyl)-2-methylfuran-3-carbothioamide ≥90% | AA0026C8 | 1mg | $364 |
| UC-781 98% | AD250064 | 5MG | $660 |
| N-(4-CHLORO-3-[(3-METHYLBUT-2-EN-1-YL)OXY]PHENYL)-2-METHYLFURAN-3-CARBOTHIOAMIDE 95.00% | HCH0140600 | 5MG | $500.67 |
| Boiling point | 440.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.240±0.06 g/cm3(Predicted) |
| pka | 9.78±0.70(Predicted) |
| FDA UNII | L7K247H29H |
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | BA1974 | UC-781 | 178870-32-1 | 1mg | $205 | 2026-05-06 | Buy |
| aablocks | AA0026C8 | N-(4-Chloro-3-((3-methylbut-2-en-1-yl)oxy)phenyl)-2-methylfuran-3-carbothioamide ≥90% | 178870-32-1 | 1mg | $364 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD250064 | UC-781 98% | 178870-32-1 | 5MG | $660 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | HCH0140600 | N-(4-CHLORO-3-[(3-METHYLBUT-2-EN-1-YL)OXY]PHENYL)-2-METHYLFURAN-3-CARBOTHIOAMIDE 95.00% | 178870-32-1 | 5MG | $500.67 | 2021-12-16 | Buy |
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Chemical Properties,Uses,Production
Uses
UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance[1][2][3].
in vivo
UC-781 (100 μl 5% UC-781 replens gel; intravaginal; once daily for 10 days) releases from gel preparation and shows low toxicity to normal tissues in female rabbit[1].
| Animal Model: | Female rabbit (~1200 g; 10 weeks old)[1]. |
| Dosage: | 100 μl 5% UC-781 replens gel. |
| Administration: | Intravaginal; once daily for 10 days. |
| Result: | Released from gel preparation and had normal histology without significant increases inflammatory cells in rabbits. |
IC 50
HIV-1: 0.005 μM (IC50)
References
[1] Balzarini J, et al. Preclinical studies on thiocarboxanilide UC-781 as a virucidal agent. AIDS. 1998 Jul 9;12(10):1129-38. DOI:10.1097/00002030-199810000-00004
[2] Van Herrewege Y, et al. In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. Antimicrob Agents Chemother. 2004 Jan;48(1):337-9. DOI:10.1128/AAC.48.1.337-339.2004
[3] Balzarini J, et al. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Mol Pharmacol. 1996 Aug;50(2):394-401. PMID:8700148
[4] Fletcher P, et al. The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86. DOI:10.1128/JVI.79.17.11179-11186.2005
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-chloro-3-(3-methylbut-2-enoxy)phenyl]-2-methyl-furan-3-carbothioamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20033 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11972 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29868 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 10000 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | -- | Sales@sangon.com | China | 6710 | 58 |
