4-Methoxy-3-(trifluoromethyl)aniline
- CAS No.
- 393-15-7
- Chemical Name:
- 4-Methoxy-3-(trifluoromethyl)aniline
- Synonyms
- TIMTEC-BB SBB002596;3-Amino-6-methoxybenzotriflo;3-TRIFLUOROMETHYL-P-ANISIDINE;3-Amino-6-methoxybenzotrifloride;4-Amino-2-trifluoromethylanisole;3-AMINO-6-METHOXYBENZOTRIFLUORIDE;3-Amino-6-methoxybenzotriflyoride;5-AMINO-2-METHOXYBENZOTRIFLUORIDE;5-Amino-2-methoxybenzotrifluoroide;3-trifluoromethyl-4-methoxyaniline
- CBNumber:
- CB2145893
- Molecular Formula:
- C8H8F3NO
- Molecular Weight:
- 191.15
- MDL Number:
- MFCD00043460
- MOL File:
- 393-15-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Methoxy-3-(trifluoromethyl)aniline | FM132712 | 5g | $900 |
| 4-Methoxy-3-(trifluoromethyl)aniline | FM132712 | 50g | $900 |
| 4-Methoxy-3-(trifluoromethyl)aniline | FM132712 | 25g | $900 |
| 4-Methoxy-3-(trifluoromethyl)aniline | FM132712 | 10g | $900 |
| 4-Methoxy-3-(trifluoromethyl)aniline | FM132712 | 100g | $900 |
| More product size | |||
| Melting point | 28 °C |
|---|---|
| Boiling point | 112 °C |
| Density | 1.280±0.06 g/cm3(Predicted) |
| Flash point | 112°C/18mm |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 3.98±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| BRN | 2723972 |
| InChI | InChI=1S/C8H8F3NO/c1-13-7-3-2-5(12)4-6(7)8(9,10)11/h2-4H,12H2,1H3 |
| InChIKey | CQJCPOVTPNWVBW-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(OC)C(C(F)(F)F)=C1 |
| CAS DataBase Reference | 393-15-7(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,T,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-52-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN2811 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | TOXIC | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2922290090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Methoxy-3-(trifluoromethyl)aniline price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM132712 | 4-Methoxy-3-(trifluoromethyl)aniline | 393-15-7 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FM132712 | 4-Methoxy-3-(trifluoromethyl)aniline | 393-15-7 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FM132712 | 4-Methoxy-3-(trifluoromethyl)aniline | 393-15-7 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FM132712 | 4-Methoxy-3-(trifluoromethyl)aniline | 393-15-7 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FM132712 | 4-Methoxy-3-(trifluoromethyl)aniline | 393-15-7 | 100g | $900 | 2026-06-04 | Buy |
4-Methoxy-3-(trifluoromethyl)aniline Chemical Properties,Uses,Production
Uses
4-Methoxy-3-(trifluoromethyl)aniline is a fluorinated aniline derivative used as a pharmaceutical intermediate for the synthesis of antibacterial and antiparasitic quinoxaline-2,3-diamine derivatives.
Synthesis
654-76-2
393-15-7
The general procedure for the synthesis of 4-methoxy-3-trifluoromethylaniline using 2-methoxy-5-nitrobenzotrifluoride as starting material was as follows: 2-methoxy-5-nitrobenzotrifluoride (5.08 g, 23.0 mmol) was dissolved in methanol (200 mL), and 10% Pd-C catalyst (50% water, 250 mg) was added. The reaction mixture was stirred continuously for 3.5 h at room temperature and under atmospheric pressure hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to dryness under reduced pressure to afford 4-methoxy-3-(trifluoromethyl)aniline (4.67 g, 100% yield). Results of mass spectrometry analysis: m/z = 192 ([M+H]+).
References
[1] Patent: EP1403255, 2004, A1. Location in patent: Page 121
[2] Patent: US2005/209260, 2005, A1. Location in patent: Page/Page column 143-144
[3] Patent: US2007/49609, 2007, A1. Location in patent: Page/Page column 122
[4] Synthesis, 2006, # 19, p. 3316 - 3340
[5] Patent: FR745293, 1932,
4-Methoxy-3-(trifluoromethyl)aniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14303 | 58 |
View Lastest Price from 4-Methoxy-3-(trifluoromethyl)aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-22 | 5-Amino-2-methoxybenzotrifluoride
393-15-7
|
1KG | 97.8% | 100 tons | Honest Joy Holdings Limited
|
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 |
2020-01-01 | 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
393-15-7
|
$1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 5-Amino-2-methoxybenzotrifluoride
393-15-7
- $0.00
- 97.8%
- Honest Joy Holdings Limited
-
- 5-AMINO-2-METHOXYBENZOTRIFLUORIDE
393-15-7
- $1.00
- 99%
- Career Henan Chemical Co
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