4-Fluorobenzenesulfonyl chloride
- CAS No.
- 349-88-2
- Chemical Name:
- 4-Fluorobenzenesulfonyl chloride
- Synonyms
- uorobenzenesuL;4-Fluorobenzenesulfonyl;P-Fluorophenyl chloride;4-Fluorbenzolsulfonylchlorid;chloro(4-fluorophenyl)sulfone;4-fluoro-benzenesulfonylchlorid;4-FLUOROBENZENSULFONYL CHLORIDE;Benzenesulfonyl chloride, 4-f;4-Fluorophenylsulfonyl chloride;p-Fluorophenylsulfonyl chloride
- CBNumber:
- CB2233466
- Molecular Formula:
- C6H4ClFO2S
- Molecular Weight:
- 194.61
- MDL Number:
- MFCD00007438
- MOL File:
- 349-88-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Fluorobenzenesulfonyl chloride 98% | F6206 | 5g | $32.3 |
| 4-Fluorobenzenesulfonyl chloride 98% | F6206 | 25g | $92.5 |
| 4-Fluorobenzenesulfonyl Chloride >97.0%(GC)(T) | F0202 | 5g | $25 |
| 4-Fluorobenzenesulfonyl Chloride >97.0%(GC)(T) | F0202 | 25g | $57 |
| 4-Fluorobenzenesulfonyl chloride Asreported | 276015 | 25g | $333 |
| More product size | |||
| Melting point | 29-31 °C (lit.) |
|---|---|
| Boiling point | 95-96 °C/2 mmHg (lit.) |
| Density | 1.467 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | dioxane: 0.1 g/mL, clear |
| form | Crystalline Low Melting Mass |
| color | White to light brown |
| Sensitive | Moisture Sensitive |
| BRN | 2091633 |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C6H4ClFO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H |
| InChIKey | BFXHJFKKRGVUMU-UHFFFAOYSA-N |
| SMILES | C1(S(Cl)(=O)=O)=CC=C(F)C=C1 |
| CAS DataBase Reference | 349-88-2(CAS DataBase Reference) |
| FDA UNII | 2M9GLL38TN |
| EPA Substance Registry System | Benzenesulfonyl chloride, 4-fluoro- (349-88-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-28-36/37/39-45-28A-27 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29049090 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
4-Fluorobenzenesulfonyl chloride price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | F6206 | 4-Fluorobenzenesulfonyl chloride 98% | 349-88-2 | 5g | $32.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | F6206 | 4-Fluorobenzenesulfonyl chloride 98% | 349-88-2 | 25g | $92.5 | 2026-04-30 | Buy |
| TCI Chemical | F0202 | 4-Fluorobenzenesulfonyl Chloride >97.0%(GC)(T) | 349-88-2 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | F0202 | 4-Fluorobenzenesulfonyl Chloride >97.0%(GC)(T) | 349-88-2 | 25g | $57 | 2026-04-30 | Buy |
| Usbiological | 276015 | 4-Fluorobenzenesulfonyl chloride Asreported | 349-88-2 | 25g | $333 | 2026-06-03 | Buy |
4-Fluorobenzenesulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
white to light brown crystalline low melting mass
Uses
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
Synthesis
371-42-6
349-88-2
The general procedure for the synthesis of 4-fluorobenzenesulfonyl chloride from p-fluorobenzenethiol is as follows: a mixture of mercaptan (1 mmol), 30% H2O2 (3 mmol, 0.3 mL), and TiCl4 (1 mmol, 0.11 mL) was reacted in CH3CN with stirring at 25 °C for the time referred to in Table 1.The reaction was carried out by the immediate precipitation of white solid (TiO2) . The progress of the reaction was monitored by TLC, and upon completion of the reaction, the reaction mixture was quenched by the addition of H2O (10 mL) and subsequently extracted with EtOAc (4 × 5 mL). The organic phases were combined and dried with anhydrous MgSO4. The filtrate was concentrated under reduced pressure to give an analytically pure product. The product can be further purified by short silica gel column chromatography and structurally confirmed by 1H NMR, 13C NMR spectroscopic analysis and comparison of melting points with real samples prepared by known methods.
References
[1] Journal of Organic Chemistry, 2009, vol. 74, # 24, p. 9287 - 9291
[2] Synlett, 2009, # 17, p. 2773 - 2776
[3] Bulletin of the Korean Chemical Society, 2011, vol. 32, # 10, p. 3692 - 3695
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2012, vol. 187, # 6, p. 769 - 775
[5] Journal of Organic Chemistry, 2007, vol. 72, # 15, p. 5847 - 5850
4-Fluorobenzenesulfonyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14026 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 923 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2950 | 58 |
View Lastest Price from 4-Fluorobenzenesulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | 4-Fluorobenzene Sulfonyl Chloride
349-88-2
|
$20.00 | 1KG | 99% | 300 Tons/ year | Speranza Chemical Co., Ltd. | |
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2026-07-09 | chloro(4-fluorophenyl)sulfone
349-88-2
|
$10.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 4-Fluorobenzenesulfonyl chloride
349-88-2
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
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- 4-Fluorobenzene Sulfonyl Chloride
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- chloro(4-fluorophenyl)sulfone
349-88-2
- $10.00
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- Henan Fengda Chemical Co., Ltd
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- 4-Fluorobenzenesulfonyl chloride
349-88-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
