2-Acetyl-3-methyl-5-methoxyphenol
- CAS No.
- 6540-66-5
- Chemical Name:
- 2-Acetyl-3-methyl-5-methoxyphenol
- Synonyms
- Acetoevernone;6'-Methyl paeonol;2-Acetyl-3-methyl-5-methoxyphenol;1-(2-Hydroxy-4-methoxy-6-methylphenyl)ethanone;Ethanone, 1-(2-hydroxy-4-methoxy-6-methylphenyl)-
- CBNumber:
- CB22353805
- Molecular Formula:
- C10H12O3
- Molecular Weight:
- 180.2
- MDL Number:
- MOL File:
- 6540-66-5.mol
2-Acetyl-3-methyl-5-methoxyphenol Chemical Properties,Uses,Production
Uses
6’-Methyl paeonol is a paeonol derivative, which inihibits abnormal depolarizations and reduces the Amyloid β-induced ERK phosphorylation. 6’-Methyl paeonol exhibits alleviating activity against Alzheimer’s Disease[1].
Preparation
Preparation by partial methylation of 2,4-dihydroxy-6-methylacetophenone (orcacetophenone or b-orcacetophenone), with diazomethane (78%) or dimethyl sulfate.
in vivo
6’-Methyl paeonol (20 mg/kg, s.c.) ameliorates the impairment of memory and learning behavior in J20 mice[1].
| Animal Model: | APP transgenic C57BL/6 mice (J20 mice)[1] |
| Dosage: | 20 mg/kg |
| Administration: | subcutaneous injection |
| Result: | Reduced the time for mice reaching hidden platform. |
References
[1] Chen PJ, et al., Derivative, 6'-Methyl Paeonol, Attenuates Aβ-Induced Pathophysiology in Cortical Neurons and in an Alzheimer's Disease Mice Model. ACS Chem Neurosci. 2024 Feb 21;15(4):724-734. DOI:10.1021/acschemneuro.3c00633
2-Acetyl-3-methyl-5-methoxyphenol Preparation Products And Raw materials
2-Acetyl-3-methyl-5-methoxyphenol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29867 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
