87134-87-0

中文名稱 CS-2692

英文名稱 R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE

CAS 87134-87-0

分子式 C17H19Cl2NO

分子量 324.24

MOL 文件 87134-87-0.mol

87134-87-0 結(jié)構(gòu)式

基本信息物理化學性質(zhì) 安全數(shù)據(jù) 圖譜信息 CS-2692價格(試劑級) 常見問題列表

基本信息

中文別名

化合物 T12865
化合物SCH-23390 MALEATE

英文別名

CS-2692
SCH 23390
SCH23390HCl
SCH-23390 maleate
R-(+)-SCH-23390 maleate
R(+)-SCH-23390 HYDROCHLORIDE
(R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
R-(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HCL
8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R)
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-, hydrochloride, (5R)-

物理化學性質(zhì)

溶解度H₂O: ≥5 mg/mL

形態(tài)solid

顏色white

安全數(shù)據(jù)

WGK Germany3

圖譜信息

CS-2692(87134-87-0)核磁圖(¹HNMR)

CS-2692價格(試劑級)

報價日期	產(chǎn)品編號	產(chǎn)品名稱	CAS號	包裝	價格
2021/03/30	S2834	CS-2692 SCH-23390 maleate	87134-87-0	25mg	7199.01元

常見問題列表

生物活性

SCH-23390 maleate (R-(+)-SCH-23390 maleate) 是一種有效的選擇性的多巴胺 D1 樣受體拮抗劑，其對 D1 和 D5 受體的 Ki 分別為 0.2 nM 和 0.3 nM。SCH-23390 maleate 也是一種有效的人 5-HT2C 受體激動劑，Ki 為 9.3 nM。SCH-23390 maleate 與 5-HT2 和 5-HT1C 受體具有高親和力。SCH-23390 maleate 還抑制 G 蛋白偶聯(lián)的內(nèi)向整流鉀 (GIRK) 通道，IC50 為 268 nM。

靶點

D ₁ Receptor

0.2 nM (Ki)

D ₅ Receptor

0.3 nM (Ki)

5-HT _2C Receptor

9.3 nM (Ki)

GIRK

268 nM (IC ₅₀ )

體外研究

SCH-23390 (1?μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway.

體內(nèi)研究

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D ₁ receptors in rodents, nonhuman primates, and humans.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat.
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O ₂ conditions.