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ChemicalBook >> CAS DataBase List >>LY411575

LY411575

CAS No.
209984-57-6
Chemical Name:
LY411575
Synonyms
CS-509;LY411575;LY4114575;LSN-411575;LY411575, >=98%;LY411575;LY 411575;LY-411575 >=97% (HPLC);LY-411575, 10 mM in DMSO;LY-411575;LY411575; LY 411575;LY411575, 98%, a γ-secretase inhibitor
CBNumber:
CB22464309
Molecular Formula:
C26H23F2N3O4
Molecular Weight:
479.48
MDL Number:
MFCD09832551
MOL File:
209984-57-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
LY-411575 ≥97% (HPLC) SML0506 5mg $142
LY-411575 ≥97% (HPLC) SML0506 25mg $566
LY-411575 L0359 5MG $107
LY411575 ≥98% 16162 1mg $41
LY411575 ≥98% 16162 5mg $128
More product size

LY411575 Properties

Boiling point 836.0±65.0 °C(Predicted)
Density 1.40
storage temp. -20°C
solubility DMSO: soluble5mg/mL, clear
form powder
pka 11.79±0.20(Predicted)
color white to beige
InChIKey ULSSJYNJIZWPSB-CVRXJBIPSA-N
SMILES C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements  24/25
WGK Germany  3
HS Code  29337900
Storage Class 11 - Combustible Solids

LY411575 price More Price(88)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0506 LY-411575 ≥97% (HPLC) 209984-57-6 5mg $142 2026-04-30 Buy
Sigma-Aldrich SML0506 LY-411575 ≥97% (HPLC) 209984-57-6 25mg $566 2026-04-30 Buy
TCI Chemical L0359 LY-411575 209984-57-6 5MG $107 2026-04-30 Buy
Cayman Chemical 16162 LY411575 ≥98% 209984-57-6 1mg $41 2026-04-30 Buy
Cayman Chemical 16162 LY411575 ≥98% 209984-57-6 5mg $128 2026-04-30 Buy
Product number Packaging Price Buy
SML0506 5mg $142 Buy
SML0506 25mg $566 Buy
L0359 5MG $107 Buy
16162 1mg $41 Buy
16162 5mg $128 Buy

LY411575 Chemical Properties,Uses,Production

Description

γ-Secretase is a multi-subunit aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. One well-known substrate of this enzyme is Notch, a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis. LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that has been shown to block Notch activation in vitro at 500 μM. LY411575 can induce apoptosis in Kaposi’s sarcoma cells as well as promote intestinal goblet cell differentiation in a mouse model of colitis. It has also been observed to promote neural differentiation of mouse embryonic stem cells.

Uses

LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.

Definition

ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.

Biochem/physiol Actions

LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.

target

γ-secretase

References

[1] EVA CZIRR. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.[J]. The Journal of Biological Chemistry, 2007, 282 34: 24504-24513. DOI: 10.1074/jbc.m700618200
[2] CHRISTINE L CURRY. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi”s sarcoma tumor cells[J]. Oncogene, 2005, 24 42: 6333-6344. DOI: 10.1038/sj.onc.1208783
[3] RYUICHI OKAMOTO. Requirement of Notch activation during regeneration of the intestinal epithelia.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2009, 296 1: G23-35. DOI: 10.1152/ajpgi.90225.2008
[4] ELSA ABRANCHES. Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo.[J]. PLoS ONE, 2009: e6286. DOI: 10.1371/journal.pone.0006286

LY411575 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 158)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29792 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32468 58
ANHUI WITOP BIOTECH CO., LTD 		+8618071025641 eric@witopchemical.com China 23541 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19853 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10457 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24597 58

View Lastest Price from LY411575 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LY-411575 pictures 2026-07-27 LY-411575
209984-57-6
 $38.00-107.00 98.05% 10g TargetMol Chemicals Inc.
LY411575 pictures 2020-01-08 LY411575
209984-57-6
 1KG 98%; 99% 1kg; 10kg; 25kg Career Henan Chemical Co
  • LY-411575 pictures
  • LY-411575
    209984-57-6
  • $38.00-107.00
  • 98.05%
  • TargetMol Chemicals Inc.
  • LY411575 pictures
  • LY411575
    209984-57-6
  • $0.01
  • 98%; 99%
  • Career Henan Chemical Co

LY411575 Spectrum

LY411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide (S)-2-(2-(3,5-difluorophenyl)acetaMido)-N-((S)-5-Methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanaMide Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)- (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LY 411575 LY 411575 (aS)-N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-alpha-hydroxybenzeneacetamide LSN-411575 N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide LY411575, >=98% LY-411575;LY411575; LY 411575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dib LY411575, 98%, a γ-secretase inhibitor CS-509 LY411575;LY 411575 LY-411575 >=97% (HPLC) LY4114575 (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propanamide LY-411575, 10 mM in DMSO 209984-57-6 C26H23F2N3O4 Inhibitor Inhibitors
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