OTAVA-BB 1217676
- CAS No.
- 120711-81-1
- Chemical Name:
- OTAVA-BB 1217676
- Synonyms
- OTAVA-BB 1217676;7-Nitro-3,4-dihydrobenzo[1,4]oxazine;7-Nitro-3,4-dihydro-2H-1,4-benzoxazine;7-Nitro-3,4-dihydro-2H-1,4-benzooxazine;2H-1,4-Benzoxazine, 3,4-dihydro-7-nitro-;7-Nitro-3,4-dihydro-2H-benzo[1,4]oxazine;7-Nitro-3,4-dihydro-2H-1,4-benzoxazine,97%;3,4-Dihydro-7-nitro-2H-benzo[b][1,4]oxazine;7-NITRO-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE
- CBNumber:
- CB22465553
- Molecular Formula:
- C8H8N2O3
- Molecular Weight:
- 180.16
- MDL Number:
- MFCD11603433
- MOL File:
- 120711-81-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine | VBP00107 | 1g | $463 |
| 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | OR904351 | 100mg | $21 |
| 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | OR904351 | 250mg | $24 |
| 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | OR904351 | 1g | $81 |
| 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | OR904351 | 5g | $285 |
| Melting point | 187-188° |
|---|---|
| Boiling point | 341.6±42.0 °C(Predicted) |
| Density | 1.332±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 0.23±0.20(Predicted) |
| Appearance | Light yellow to yellow Solid |
| Water Solubility | Sparingly soluble in water (0.76 g/L at 25°C). |
| CAS DataBase Reference | 120711-81-1 |
OTAVA-BB 1217676 price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | VBP00107 | 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine | 120711-81-1 | 1g | $463 | 2023-06-20 | Buy |
| Apolloscientific | OR904351 | 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | 120711-81-1 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR904351 | 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | 120711-81-1 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR904351 | 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | 120711-81-1 | 1g | $81 | 2026-06-04 | Buy |
| Apolloscientific | OR904351 | 7-Nitro-3,4-dihydro-2H-1,4-benzoxazine 97% | 120711-81-1 | 5g | $285 | 2026-06-04 | Buy |
OTAVA-BB 1217676 Chemical Properties,Uses,Production
Uses
7-Nitro-3,4-dihydro-2H-1,4-benzooxazine can be used as pain drugs to prevent and treat chronic pain.
Synthesis
81721-86-0
120711-81-1
The general procedure for the synthesis of 7-nitro-3,4-dihydro-2H-1,4-benzisoxazin-3-one from 7-nitro-2H-1,4-benzisoxazin-3-one was as follows: 7-nitro-4H-benzo[1,4]oxazin-3-one (2.00 g, 10.3 mmol) was dissolved in tetrahydrofuran (THF, 10 mL), and borane-THF complex was added subsequently ( 1.0 M solution of THF, 35 mL). The reaction mixture was heated to reflux for 30 min, then cooled to 0 °C and the reaction was quenched with 1 N hydrochloric acid (20 mL). After continued stirring for 30 min, the reaction solution was concentrated to 1/10 of the original volume. the orange solid product was collected by filtration, washed with water and dried under vacuum to afford 7-nitro-3,4-dihydro-2H-1,4-benzisoxazine (1.66 g, 89% yield). The mass spectrum (electrospray positive ion mode) showed m/z 181.1 ([M+H]+) and the mass spectrum (electrospray negative ion mode) showed m/z 179.2 ([M-H]-).1H NMR (400 MHz, DMSO-d6) data were as follows: δ 7.68 (dd, 1H, J = 8.8, 2.6 Hz), 7.53 (s, 1H), 7.47 (d , 1H, J = 2.6 Hz), 6.63 (d, 1H, J = 9.2 Hz), 4.15 (t, 2H, J = 4.4 Hz), 3.44-3.40 (m, 2H).
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2486 - 2496
[2] Patent: WO2006/66174, 2006, A1. Location in patent: Page/Page column 52-53
[3] Patent: US2010/9975, 2010, A1. Location in patent: Page/Page column 35
[4] Journal of the American Chemical Society, 2014, vol. 136, # 38, p. 13277 - 13282
[5] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3821 - 3830
OTAVA-BB 1217676 Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
OTAVA-BB 1217676 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52906 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 16305 | 64 |
