(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate
- CAS No.
- 91103-37-6
- Chemical Name:
- (S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate
- Synonyms
- tert-butyl (S)-(1-hydroxybut-3-en-2-yl)carbamate;(S)-2-(Boc-amino)-3-buten-1-ol;(s)-2-(boc-amino)-2-vinyl-ethanol;(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate;tert-butyl N-[(1S)-1-(hydroxymethyl)allyl]carbamate;tert-butyl [(1S)-1-(hydroxymethyl)prop-2-en-1-yl]carbamate;tert-Butyl (S)-(1-hydroxybut-3-en-2-yl)carbamate,97%(stabilized with MEHQ);CarbaMic acid, [(1S)-1-(hydroxyMethyl)-2-propenyl]-, 1,1-diMethylethylester;Carbamic acid, N-[(1S)-1-(hydroxymethyl)-2-propen-1-yl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB22505862
- Molecular Formula:
- C9H17NO3
- Molecular Weight:
- 187.24
- MDL Number:
- MFCD07366803
- MOL File:
- 91103-37-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 308797 | 250.00mg | $50 |
| (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 308797 | 1.00g | $173 |
| (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 308797 | 5.00g | $600 |
| (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate 97%(stabilizedwithTBC) | AA00H10K | 100mg | $16 |
| (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate 97%(stabilizedwithTBC) | AA00H10K | 250mg | $32 |
| Boiling point | 302.9±35.0 °C(Predicted) |
|---|---|
| Density | 1.026±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| pka | 11.60±0.46(Predicted) |
| Appearance | Colorless to off-white Solid-Liquid Mixture |
| optical activity | -29.5° (c=1.00 g/100ml, CHCL3) |
| InChI | InChI=1S/C9H17NO3/c1-5-7(6-11)10-8(12)13-9(2,3)4/h5,7,11H,1,6H2,2-4H3,(H,10,12)/t7-/m0/s1 |
| InChIKey | HYVYNSIWYIWTCK-ZETCQYMHSA-N |
| SMILES | C(OC(C)(C)C)(=O)N[C@H](CO)C=C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 308797 | (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 91103-37-6 | 250.00mg | $50 | 2026-05-19 | Buy |
| Matrix Scientific | 308797 | (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 91103-37-6 | 1.00g | $173 | 2026-05-19 | Buy |
| Matrix Scientific | 308797 | (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate | 91103-37-6 | 5.00g | $600 | 2026-05-19 | Buy |
| aablocks | AA00H10K | (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate 97%(stabilizedwithTBC) | 91103-37-6 | 100mg | $16 | 2026-05-28 | Buy |
| aablocks | AA00H10K | (S)-tert-Butyl (1-hydroxybut-3-en-2-yl)carbamate 97%(stabilizedwithTBC) | 91103-37-6 | 250mg | $32 | 2026-05-28 | Buy |
(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate Chemical Properties,Uses,Production
Synthesis
133625-87-3
91103-37-6
General procedure for the synthesis of tert-butyl (S)-(1-hydroxybut-3-en-2-yl)carbamate from tert-butyl (S)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate: To a methanol (83 mL) solution of tert-butyl (S)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate (1.90 g, 8.36 mmol) at 0 °C was added tert-butyl (S)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate (1.80 g, 8.36 mmol). ) solution was added to p-toluenesulfonic acid monohydrate (0.80 g, 4.2 mmol). The reaction mixture was slowly warmed to room temperature and stirred overnight. After the reaction was completed, the reaction mixture was diluted with saturated NaHCO3 solution and then concentrated. The mixture was extracted with ethyl acetate and the organic layer was sequentially washed twice with saturated aqueous NaHCO3 solution and then with brine. The organic layer was dried with Na2SO4, filtered and concentrated to afford the target product tert-butyl (S)-(1-hydroxybut-3-en-2-yl)carbamate as a colorless oil (1.187 g, 76% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 5.81 (1H, m), 5.25 (2H, m), 4.90 (1H, m), 4.25 (1H, br s), 3.67 (2H, m), 1.45 (9H, s) ppm.
References
[1] Patent: US2014/121198, 2014, A1. Location in patent: Paragraph 0645; 0647
[2] Patent: WO2015/26818, 2015, A1. Location in patent: Page/Page column 44
[3] Patent: WO2015/157257, 2015, A1. Location in patent: Page/Page column 37; 38
[4] Patent: US2015/361094, 2015, A1. Location in patent: Paragraph 0354
[5] Tetrahedron Asymmetry, 2001, vol. 12, # 6, p. 817 - 819
(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate Preparation Products And Raw materials
(S)-tert-butyl 1-hydroxybut-3-en-2-ylcarbamate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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