1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- CAS No.
- 1020174-04-2
- Chemical Name:
- 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
- Synonyms
- 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Methylpyrazole-3-boronic Acid Pinacol Ester;1-Methylpyrazol-3-yl-boronic acid pinacol ester;(1-METHYL-1H-PYRAZOL-3-YL)BORONIC ACID PINACOL ESTER;1-Methyl-3-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-Methylpyrazol-3-yl-4,4,5,5-tetraMethyl-[1,3,2]dioxaborolane;1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-...;1H-Pyrazole, 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;1-Methyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole - [M16052]
- CBNumber:
- CB22549680
- Molecular Formula:
- C10H17BN2O2
- Molecular Weight:
- 208.07
- MDL Number:
- MFCD04114000
- MOL File:
- 1020174-04-2.mol
| Product description | Number | Pack Size | Price |
| 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | FM74794 | 10g | $900 |
| 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | FM74794 | 25g | $900 |
| 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | FM74794 | 5g | $900 |
| 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | FM74794 | 50g | $1298 |
| 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | FM74794 | 100g | $2077 |
| More product size | |||
| Boiling point | 308.3±15.0 °C(Predicted) |
|---|---|
| Density | 1.05 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 2.23±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-7-13(5)12-8/h6-7H,1-5H3 |
| InChIKey | BJMSXWLXFYZHIU-UHFFFAOYSA-N |
| SMILES | N1(C)C=CC(B2OC(C)(C)C(C)(C)O2)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H302-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
| HS Code | 29349990 |
1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FM74794 | 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | 1020174-04-2 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FM74794 | 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | 1020174-04-2 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FM74794 | 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | 1020174-04-2 | 5g | $900 | 2026-06-04 | Buy |
| Biosynth | FM74794 | 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | 1020174-04-2 | 50g | $1298 | 2026-06-04 | Buy |
| Biosynth | FM74794 | 1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1h-pyrazole | 1020174-04-2 | 100g | $2077 | 2026-06-04 | Buy |
1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Uses,Production
Uses
1-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is patented as a reagent to synthesize quinoxaline derivatives or heterocyclylamine derivatives as PI3 kinase inhibitors.
Synthesis
151049-87-5
73183-34-3
1020174-04-2
General procedure for the synthesis of 1-methylpyrazole-3-boronic acid pinacol ester from 3-bromo-1-methylpyrrole and bis(pinacolato)diboronic acid: firstly, compound 701 (3-bromo-1-methylpyrrole, 0.2 g, 1.24 mmol) was dissolved in 5 mL of 1,4-dioxane. Subsequently, bis(pinacolato)diboron (0.378 g, 1.49 mmol), potassium acetate (0.365 g, 3.72 mmol), and [1,1-bis(diphenylphosphino)ferrocene]palladium chloride dichloromethane complex (0.11 g, 0.124 mmol) were added to this solution. The reaction mixture was heated to 95 °C under nitrogen protection and kept at this temperature for 5 hours of reaction. After completion of the reaction, the mixture was cooled to room temperature. To the reaction mixture was added 15 mL of water, stirred for 1 hour and filtered to give 0.114 g of solid product, 1-methylpyrazole-3-boronic acid pinacol ester. The yield was 44.19%.
References
[1] Patent: EP3072893, 2016, A1. Location in patent: Paragraph 0394; 0395
[2] Patent: EP2818473, 2014, A1. Location in patent: Paragraph 0578
1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8886 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9047 | 58 |
View Lastest Price from 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-13 | 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
|
$1.00 | 1KG | 98%-100% | 1 | Career Henan Chemical Co |
-
- 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
1020174-04-2
- $1.00
- 98%-100%
- Career Henan Chemical Co
