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ChemicalBook >> CAS DataBase List >>Erlotinib Hydrochloride iMpurity

Erlotinib Hydrochloride iMpurity

CAS No.
882420-22-6
Chemical Name:
Erlotinib Hydrochloride iMpurity
Synonyms
(Z)-N-(3-(2-chlorovinyl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine;OSI-356;Erlotinib Chloro;Hydroxy Erlotinib;4-Hydroxy Erlotinib;Erlotinib Impurity 10;Erlotinib Impurity 17;Erlotinib Impurity 14;Erlotinib metabolite -2;Erlotinib Hydrochloride IMP
CBNumber:
CB22669443
Molecular Formula:
C22H23N3O5
Molecular Weight:
409.44
MDL Number:
MFCD30741276
MOL File:
882420-22-6.mol
Last updated:2026-01-12 17:28:22

Erlotinib Hydrochloride iMpurity Properties

CAS DataBase Reference 882420-22-6
FDA UNII 3OAQ9M99Y2

Erlotinib Hydrochloride iMpurity Chemical Properties,Uses,Production

Synthesis

A mixture of N'-[2-cyano-4,5-bis(2-methoxyethoxy)phenyl]-N,N-dimethyl-formamidine (compound of Formula II) 60g, with m-aminophenylacetylene (compound of Formula III) 30g, and acetic acid 300mL, was heated with stirring at a temperature of 95~105 for 20~40min; cooled down to 85~90, and dropwise added 4:1 volume ratio of tert-butanol/water mixed solvent 60mL, stirring the reaction under heat preservation for 25min; the reaction was completed, cooled to room temperature, and the reaction solution was concentrated under reduced pressure to obtain about 91g of the crude product containing the target (formula I); using column chromatography, the eluent was dichloromethane/methanol=60:1 (v/v), and the formula I compounds in the crude product were subjected to column chromatography to obtain an isolate of about 4.1g. HPLC The purity was 96.2%. About 4.1 g of the above isolate was added to the mixed solvent of isopropanol and ethyl acetate, isopropanol: ethyl acetate=4:1 (v/v), heated to reflux, all dissolved and then filtered while hot, and the filtrate was left to precipitate crystals for 7~8h at -5~0C, dried, to obtain a high purity of erlotinib impurity of about 3.7 g. The purity of HPLC was 99.30%.

Erlotinib Hydrochloride iMpurity Preparation Products And Raw materials

Raw materials

Preparation Products

Erlotinib Hydrochloride iMpurity Suppliers

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Erlotinib Chloro 3-Ethynylailine Hydrochloride 1 4-Hydroxy Erlotinib Erlotinib Impurity 10 Erlotinib Impurity 13 Hydrobromide Erlotinib Impurity 14 Erlotinib Impurity 17 Erlotinib Hydrochloride IMP Erlotinib 4-Hydroxy Metabolite Erlotinib impurity 6/Erlotinib Hydroxy Metabolite/4-Hydroxy Erlotinib/4-((6,7-bis(2-methoxyethoxy)quinazolin-4-yl)amino)-2-ethynylphenol ethyl 2,6-diamino-3,4-bis(2-methoxyethoxy)benzoate dihydrochloride OSI-356 Phenol, 4-[[6,7-bis(2-methoxyethoxy)-4-quinazolinyl]amino]-2-ethynyl- Hydroxy Erlotinib 4-Hydroxy Erlotinib Hydrochloride Erlotinib metabolite -2 (Z)-N-(3-(2-chlorovinyl)phenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine 882420-22-6 69450-89-9
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