2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine
- CAS No.
- 387827-64-7
- Chemical Name:
- 2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine
- Synonyms
- 5-(trifluoromethyl)-2-(2,4-difluorophenyl)pyridine;2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine;Pyridine, 2-(2,4-difluorophenyl)-5-(trifluoromethyl)-;2-(2,4-DIFLUOROPHENYL)-5-(TRIFLUOROMETHYL)PYRIDINE,98%DF(CF3)PPY;2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine (This product is unavailable in the U.S.)
- CBNumber:
- CB22710606
- Molecular Formula:
- C12H6F5N
- Molecular Weight:
- 259.17
- MDL Number:
- MFCD28144542
- MOL File:
- 387827-64-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine ≥95% | 909335 | 1G | $280 |
| 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine min. 98.0 % | D5788 | 1G | $118 |
| 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy 98% | 07-4040 | 250mg | $110 |
| 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy 98% | 07-4040 | 1g | $325 |
| 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy | 07-4040 | 250mg | $102 |
| More product size | |||
| Melting point | 59.0-62.1°C |
|---|---|
| Boiling point | 253.4±35.0 °C(Predicted) |
| Density | 1.364±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 1.48±0.27(Predicted) |
| form | crystal |
| color | off-white microcrystal |
| InChI | InChI=1S/C12H6F5N/c13-8-2-3-9(10(14)5-8)11-4-1-7(6-18-11)12(15,16)17/h1-6H |
| InChIKey | FMKQPMDFNYNYAG-UHFFFAOYSA-N |
| SMILES | C1(C2=CC=C(F)C=C2F)=NC=C(C(F)(F)F)C=C1 |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P280-P305+P351+P338-P362-P321-P332+P313-P337+P313 |
| Risk Statements | 36/38 |
| Safety Statements | 23-26-37-60 |
| WGK Germany | WGK 3 |
| TSCA | No |
| Storage Class | 11 - Combustible Solids |
2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 909335 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine ≥95% | 387827-64-7 | 1G | $280 | 2026-04-30 | Buy |
| TCI Chemical | D5788 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine min. 98.0 % | 387827-64-7 | 1G | $118 | 2026-04-30 | Buy |
| Strem Chemicals | 07-4040 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy 98% | 387827-64-7 | 250mg | $110 | 2026-04-30 | Buy |
| Strem Chemicals | 07-4040 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy 98% | 387827-64-7 | 1g | $325 | 2026-04-30 | Buy |
| Strem Chemicals | 07-4040 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine, 98% dF(CF3)ppy | 387827-64-7 | 250mg | $102 | 2024-03-01 | Buy |
2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine Chemical Properties,Uses,Production
Uses
2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine is a ligand used for the preparation of Ir(III) photocatalysts.
reaction suitability
reaction type: Photocatalysis
reagent type: catalyst
Synthesis
52334-81-3
144025-03-6
387827-64-7
General procedure for the synthesis of 2-(2,4-difluorophenyl)-5-(trifluoromethyl)pyridine from 2-chloro-5-(trifluoromethyl)pyridine and 2,4-difluorophenylboronic acid: To a 100 mL two-necked round-bottomed flask equipped with a magnetic stirrer were added 2-chloro-5-trifluoromethylpyridine (1 equiv), 2,4-difluorophenylboronic acid (1.2 equiv), triphenylphosphine (0.1 equiv), 2 M aqueous potassium carbonate (2.7 eq.) and ethylene glycol dimethyl ether (0.9 M). The reaction mixture was degassed with argon for 15 minutes. Subsequently, palladium acetate (2.5 mol%) was added to the reaction system and degassing was continued for 15 minutes before sealing the reaction system. The reaction mixture was heated to reflux and the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 90:10). Upon completion of the reaction (usually takes 18-24 hours), the reaction mixture was cooled to room temperature and extracted with dichloromethane (3 x 20 mL). The organic phases were combined, washed sequentially with water (3 × 20 mL) and saturated saline (120 mL), dried over anhydrous sodium sulfate, and the solvent was concentrated under reduced pressure. The crude product was purified by fast column chromatography to afford the target product 2-(2,4-difluorophenyl)-5-(trifluoromethyl)pyridine.
References
[1] Journal of Organometallic Chemistry, 2015, vol. 776, p. 51 - 59
[2] Journal of Organic Chemistry, 2016, vol. 81, # 16, p. 6988 - 6994
[3] Journal of the American Chemical Society, 2017, vol. 139, # 47, p. 17186 - 17192
[4] Chemistry - A European Journal, 2018, vol. 24, # 44, p. 11314 - 11318
2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19987 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| R&D Scientific Inc. | +1-2266000236 | sales@rdscientific.com | Canada | 1941 | 58 |
View Lastest Price from 2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-13 | 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine
387827-64-7
|
$500.00 | 1g | 98 | 500 Kg | R&D Scientific Inc. |
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- 2-(2,4-Difluorophenyl)-5-(trifluoromethyl)pyridine
387827-64-7
- $500.00
- 98
- R&D Scientific Inc.
