5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- CAS No.
- 78606-80-1
- Chemical Name:
- 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- Synonyms
- T22526;BML-111;BML111,BML 111;BML-111, Lipoxin A4 agonist;6(R)-7-trihydroxymethyl Heptanoate;1,3-Benzodioxole-9-sulfonylchloride;methyl (5R,6R)-5,6,7-trihydroxyheptanoate;(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE;5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER;5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester
- CBNumber:
- CB2296632
- Molecular Formula:
- C8H16O5
- Molecular Weight:
- 192.21
- MDL Number:
- MFCD00211214
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester ≥98% (HPLC) | SML0215 | 25mg | $560 |
| 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 10005032 | 1mg | $63 |
| 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 10005032 | 5mg | $274 |
| 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 10005032 | 10mg | $481 |
| 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 10005032 | 1mg | $57 |
| Boiling point | 360.8±42.0 °C(Predicted) |
|---|---|
| Density | 1+-.0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: ≥20mg/mL |
| pka | 13.74±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0215 | 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester ≥98% (HPLC) | 78606-80-1 | 25mg | $560 | 2022-05-15 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 5mg | $274 | 2026-04-30 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 10mg | $481 | 2026-04-30 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 1mg | $57 | 2024-03-01 | Buy |
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Chemical Properties,Uses,Production
Description
BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5
Uses
5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist.
storage
Store at -20°C
References
[1] TAK H. LEE. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships[J]. Biochemical and biophysical research communications, 1991, 180 3: Pages 1416-1421. DOI:10.1016/s0006-291x(05)81354-3
[2] MD H B L, PHD, PHD You S M, et al. BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats[J]. Journal of Surgical Research, 2013, 183 2: Pages 710-719. DOI:10.1016/j.jss.2013.03.007
[3] DINA S EL-AGAMY Nareman M G Mirhan N Makled. Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice.[J]. Journal of physiology and biochemistry, 2014, 70 1: 141-149. DOI:10.1007/s13105-013-0288-x
[4] KIMBERLY E. HAWKINS. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke[J]. Journal of Neurochemistry, 2013, 129 1: 130-142. DOI:10.1111/jnc.12607
[5] SHENG-HUA WU. BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1[J]. Inflammation, 2015, 39 1: 611-624. DOI:10.1007/s10753-015-0286-y
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301593;18013301590 | njduly@126.com | China | 3293 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4784 | 55 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2937 | 56 |
