3-Fluoro-4-methylaniline
- CAS No.
- 452-77-7
- Chemical Name:
- 3-Fluoro-4-methylaniline
- Synonyms
- 3-FLUORO-P-TOLUIDINE;3-fluoro-p-toluidin;3-Fluoro-4-methylani;4-AMINO-2-FLUOROTOLUENE;3-FLUORO-PARA-TOLUIDINE;3-FLUORO-4-METHYLANILINE;2-FLUORO-4-AMINO-TOLUENE;3-Fluoro-4-methylaniline98%;3-Fluoro-4-methylaniline>3-fluoro-4-methyl-benzenamin
- CBNumber:
- CB2301992
- Molecular Formula:
- C7H8FN
- Molecular Weight:
- 125.14
- MDL Number:
- MFCD00007762
- MOL File:
- 452-77-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Fluoro-4-methylaniline 99% | 222666 | 5g | $23.7 |
| 3-Fluoro-4-methylaniline 99% | 222666 | 25g | $82.2 |
| 3-Fluoro-4-methylaniline >98.0%(GC) | F0440 | 5g | $29 |
| 3-Fluoro-4-methylaniline >98.0%(GC) | F0440 | 25g | $77 |
| 3-Fluoro-4-methylaniline | FF104392 | 100g | $270 |
| More product size | |||
| Melting point | 30-32 °C (lit.) |
|---|---|
| Boiling point | 93°C 12mm |
| Density | 1.093 g/mL at 25 °C (lit.) |
| refractive index | 1.5385-1.5405 |
| Flash point | 88 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 4.02±0.10(Predicted) |
| form | powder to lump to clear liquid |
| color | Light yellow to Brown |
| Specific Gravity | 1.093 |
| BRN | 2715987 |
| InChI | InChI=1S/C7H8FN/c1-5-2-3-6(9)4-7(5)8/h2-4H,9H2,1H3 |
| InChIKey | MGRHBBRSAFPBIN-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(C)C(F)=C1 |
| CAS DataBase Reference | 452-77-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T,Xi,Xn | |||||||||
| Risk Statements | 36/37/38-23/24/25-20/21/22 | |||||||||
| Safety Statements | 45-36/37/39-26-36/37-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XU6825000 | |||||||||
| Hazard Note | Toxic/Irritant | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29214300 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
|||||||||
| Hazard Classifications | Acute Tox. 1 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
3-Fluoro-4-methylaniline price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 222666 | 3-Fluoro-4-methylaniline 99% | 452-77-7 | 5g | $23.7 | 2023-01-07 | Buy |
| Sigma-Aldrich | 222666 | 3-Fluoro-4-methylaniline 99% | 452-77-7 | 25g | $82.2 | 2023-01-07 | Buy |
| TCI Chemical | F0440 | 3-Fluoro-4-methylaniline >98.0%(GC) | 452-77-7 | 5g | $29 | 2026-04-30 | Buy |
| TCI Chemical | F0440 | 3-Fluoro-4-methylaniline >98.0%(GC) | 452-77-7 | 25g | $77 | 2021-12-16 | Buy |
| Biosynth | FF104392 | 3-Fluoro-4-methylaniline | 452-77-7 | 100g | $270 | 2026-06-04 | Buy |
3-Fluoro-4-methylaniline Chemical Properties,Uses,Production
Chemical Properties
clear pale yellow to brownish liquid after melting
Characteristics
3-Fluoro-4-methylaniline is an amide and has anti-cancer properties.
Uses
3-Fluoro-4-methylaniline is a synthesized compound that is used to produce anti-cancer agents.
Synthesis
1427-07-2
452-77-7
General procedure for the synthesis of 3-fluoro-4-methylaniline from 2-fluoro-4-nitrotoluene: Freshly distilled toluene (0.6 mL), aromatic nitro compounds (0.60 mmol), indium triiodide (InI3, 14.9 mg, 0.030 mmol) and 1,1,3,3-tetramethyldi siloxane (TMDS, 318 μL, 1.80 mmol). After sealing the vial with a polytetrafluoroethylene (PTFE) septum, the mixture was stirred at 60 °C (bath temperature) and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, 5 mL of aqueous sodium bicarbonate (NaHCO3) was added to the mixture, which was then extracted with ethyl acetate (EtOAc, 3 × 6 mL). The organic phases were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: n-hexane-ethyl acetate, from 9:1 to 4:1) to obtain the target product 3-fluoro-4-methylaniline.
References
[1] Tetrahedron Letters, 2003, vol. 44, # 42, p. 7783 - 7787
[2] Synthesis (Germany), 2015, vol. 47, # 20, p. 3179 - 3185
[3] Journal of the American Chemical Society, 1950, vol. 72, p. 1806
[4] Monatshefte fuer Chemie, 1959, vol. 90, p. 683,687
[5] Journal of the Chemical Society, 1949, p. Spl. 113
3-Fluoro-4-methylaniline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
View Lastest Price from 3-Fluoro-4-methylaniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3-Fluoro-4-methylaniline
452-77-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 3-Fluoro-4-methylaniline
452-77-7
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-11-18 | 3-Fluoro-4-methylaniline
452-77-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- 3-Fluoro-4-methylaniline
452-77-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Fluoro-4-methylaniline
452-77-7
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-Fluoro-4-methylaniline
452-77-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
