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4,5-Dimethyl-1,3-dioxol-2-one

4,5-Dimethyl-1,3-dioxol-2-one structure

CAS No.: 37830-90-3

Chemical Name:: 4,5-Dimethyl-1,3-dioxol-2-one

Synonyms: DMDO;4,5-Dimethyl-1,3-dioxolen-2-one;DIMETHYLDIOXOLONE;AZATMint-A;3-dioxol-2-one;ORDIMETHYLDIOXOLONE;4,5-Dimethyl-1,3-dio;Olmesartan Impurity 54;Dimethylvinylene carbonate;5-Dimethyl-1,3-dioxol-2-one

CBNumber:: CB2310781

Molecular Formula:: C5H6O3

Molecular Weight:: 114.1

MDL Number:: MFCD00135139

MOL File:: 37830-90-3.mol

MSDS File:: SDS

Last updated:2026-05-28 00:11:34

Product description	Number	Pack Size	Price
4,5-Dimethyl-1,3-dioxol-2-one	TMT00459	1G	$586
4,5-Dimethyl-1,3-dioxol-2-one >99.0%(GC)	D1920	25g	$42
4,5-Dimethyl-1,3-dioxol-2-one	FD38408	50g	$150
4,5-Dimethyl-1,3-dioxol-2-one	FD38408	100g	$150
4,5-Dimethyl-1,3-dioxol-2-one	FD38408	25g	$150
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4,5-Dimethyl-1,3-dioxol-2-one Properties

Melting point	78°C
Boiling point	130 °C / 6mmHg
Density	1.181±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform, Methanol
form	Solid
color	White
InChI	InChI=1S/C5H6O3/c1-3-4(2)8-5(6)7-3/h1-2H3
InChIKey	QYIOFABFKUOIBV-UHFFFAOYSA-N
SMILES	O1C(C)=C(C)OC1=O
CAS DataBase Reference	37830-90-3(CAS DataBase Reference)
NIST Chemistry Reference	1,3-Dioxol-2-one,4,5-dimethyl-(37830-90-3)
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Risk Statements	36/37/38-37-36
Safety Statements	26-36/37/39-36
WGK Germany	WGK 3
HS Code	29329990
Storage Class	11 - Combustible Solids

4,5-Dimethyl-1,3-dioxol-2-one price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	TMT00459	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	1G	$586	2026-04-30	Buy
TCI Chemical	D1920	4,5-Dimethyl-1,3-dioxol-2-one >99.0%(GC)	37830-90-3	25g	$42	2026-04-30	Buy
Biosynth	FD38408	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	50g	$150	2026-06-04	Buy
Biosynth	FD38408	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	100g	$150	2026-06-04	Buy
Biosynth	FD38408	4,5-Dimethyl-1,3-dioxol-2-one	37830-90-3	25g	$150	2026-06-04	Buy

Product number	Packaging	Price	Buy
TMT00459	1G	$586	Buy
D1920	25g	$42	Buy
FD38408	50g	$150	Buy
FD38408	100g	$150	Buy
FD38408	25g	$150	Buy

4,5-Dimethyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

4,5-Dimethyl-1,3-dioxol-2-one is a dioxolanone derivative used in the preparation of synthetic chemotherapeutic antibiotics such as Prulifloxacin (P838885).

Application

4,5-Dimethyl-1,3-dioxol-2-one is a kind of important medicine intermediate, is mainly used in the modification of many medicines, to synthesize, has optically active chiral drug, thereby improves largely drug effect, reduces drug side effect.

Synthesis

1. distillation column is being housed, air set pipe, mechanical stirrer, add 3-hydroxy-2-butanone 88g, methylcarbonate 90g, tirethylene glycol dme 264g and sodium propylate 0.88g in the three-necked flask of thermometer, at 60-65 ℃ of reacting by heating mixture, carry out transesterification reaction 6h, the methyl alcohol of generation is removed in synchronous distillation, obtains carbonic acid monomethyl 3-hydroxy-2-butanone base ester.
2. improve reaction mixture temperature to 110-115 ℃, keep this thermotonus 5h, continue to steam the by products such as methyl alcohol.
3., after reaction finishes, reaction mixture is to room temperature, add concentrated hydrochloric acid with the neutralization reaction catalyzer to reaction mixture pH value in 7 left and right. After methylcarbonate is reclaimed in fractionation, the underpressure distillation aliphatic ether is appropriate.The distillation residuum is cooled to 0-5 ℃, and crystallization, filtration, obtain product 4,5-dimethyl-1,3-dioxole-2-ketone crude product 62.34g.
4. add recrystallization solvent and 0.62g gac in crude product, be heated to 80 ℃ of return stirring 0.5-1h, filtered while hot, filtrate 60 ℃ of lower evaporation concentration to after having mass crystallization to separate out, adopt cooling bath cooling concentration liquid to 0-5 ℃, the gained solids is dried 2h at 50 ℃ of lower normal pressures.
Can obtain highly purified 4,5-Dimethyl-1,3-dioxol-2-one white crystal, these are highly purified 4 years old, 5-dimethyl-1, the quality of 3-dioxole-2-ketone is 53.88g, yield is 47.26% (calculating with the 3-hydroxy-2-butanone), purity (high performance liquid chromatography) is 99.0%, and fusing point is 77-78 ℃.

References

[1] Patent: CN103483308, 2017, B. Location in patent: Paragraph 0021-0023; 0025; 0027; 0029-0031; 0046-0049; 0057

4,5-Dimethyl-1,3-dioxol-2-one synthesis

Synthesis of 4,5-Dimethyl-1,3-dioxol-2-one from NISTC52217024 and Ethyl chloroformate

4,5-Dimethyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

NISTC52217024 Methyl chloroformate Ethyl chloroformate Propyl chloroformate Acetoin

Carbon dioxide Triphosgene

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Preparation Products

4,5-Dimethyl-1,3-dioxol-2-one Suppliers

Global( 434)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	+86-86-2386815286 +8613983794297	sales@ensky-chemical.com	China	94	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Chongqing Soarwin Technology Co., Ltd	+86-15790943001	crystal@sorawin.cn	China	421	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
.GZ HONESTCHEM CO.,LTD	+8615013270415	honestchemical@foxmail.com	China	299	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Tianjin Huiren Chemtech Co., Ltd	+86-86-22-23707858 +86-86-13672008665	huirentech@foxmail.com	China	171	58

Supplier	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Chongqing Soarwin Technology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
.GZ HONESTCHEM CO.,LTD	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Tianjin Huiren Chemtech Co., Ltd	58

View Lastest Price from 4,5-Dimethyl-1,3-dioxol-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-08	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3	$1.00	1KG	99.9%	500KG	.GZ HONESTCHEM CO.,LTD
2026-06-08	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3		1KG	99.5%min GC	10000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-21	4,5-Dimethyl-1,3-dioxol-2-one 37830-90-3		1KG	≥99%		Jinan Finer Chemical Co., Ltd

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
$1.00
99.9%
.GZ HONESTCHEM CO.,LTD

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
99.5%min GC
WUHAN FORTUNA CHEMICAL CO., LTD

4,5-Dimethyl-1,3-dioxol-2-one
37830-90-3
$0.00
≥99%
Jinan Finer Chemical Co., Ltd

4,5-Dimethyl-1,3-dioxol-2-one Spectrum

4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)MS 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)¹HNMR 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)¹³CNMR 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR1 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)IR2 4,5-Dimethyl-1,3-dioxol-2-one(37830-90-3)Raman

37830-90-3(4,5-Dimethyl-1,3-dioxol-2-one)Related Search:

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Selenium dioxide 1,4-Dioxane DIMETHYLGLYOXIME DISODIUM SALT 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ETHANE

Olmesartan Methyl cyclopentenolone Dimethyl sulfoxide N,N-Dimethylformamide 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester

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4,5-DIMETHYL-1,3-DIOXOL-2-ONE 1,3-DIOXOL-2-ONE, 4,5-DIMETHYL- 4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO) 5-Dimethyl-1,3-dioxol-2-one 4,5-Dimethyl-1,3-dioxolen-3-one 4,5-dimethyl-2-oxo-1,3-dioxolene DMDO (4,5-DIMETHYL-1,3-DIOXOL-2-ONE) 4,5-DIMETHYL-1,3-DIOXAL-2-ONE 4,5-DIMETHYL-1,3-DIOXOL-2-ONE (DMDO) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE(OR DIMETHYLDIOXOLONE) 4,5-DIMETHYL-1,3-DIOXOL-2-ONE 99+% 4,5-Dimethyl-1,3-dioxocyclopenten-2-one 4,5-DIMETHYL-1,3-DIOXO-2-ONE 4,5-Dimethyl-1,3-dioxolen-2-one(DDO) Carbonic acid 1,2-dimethylvinylene ester Carbonic acid 2-butene-2,3-diyl ester Dimethyl vinylene carbonate Dimethylvinylene carbonate 4,5-dimethyl-1,3-dioxa-4-cyclopentene-2-one 4,5-Dimethyl-1,3-dio 4,5-Dimethyl-1,3-dioxol-2-one dimethyldioxolone ethyldiox 3-dioxol-2-one diMethyl-2H-1,3-dioxol-2-one 4-5-Methyl-l,3-dioxocyclopenten-2–one 4,5-Dimethyl-1,3-dioxolen-3-one(DMDO) 4,5-dimethyl 1,3-2 oxygen heterocycle pentene-2-ketone 4,5-dimethyl-l,3-dioxolene-2-one (DMDO) 4,5-Dimethyl-1,3-dioxol-2-one USP/EP/BP Olmesartan Dimethyl Impurity Olmesartan DMDO-Cl Impurity Ⅴ 4,5-Dimethyl-1,3-dioxol-2-one> ORDIMETHYLDIOXOLONE Olmesartan DMDO-CL Impurity Ⅱ Olmesartan Medoxomil Impurity 37 AZATMint-A Olmesartan Impurity 54 4,5-Dimethyl-1,3-dioxole-2-one(DMDO) 4.5 Dimethyl 1.3 dioxane 2-one 4,5-Dimethy-1,3-dioxol-2-one(DMDO) 4,5-dimethyl-1,3-dioxolane-2-one 4,5-Dimethyl-1,3-dioxolen-2-one DIMETHYLDIOXOLONE DMDO 37830-90-3 Pharmaceutical Intermediates Agricultural chemicals(bactericide) Oxygen cyclic compounds Fluorobenzene

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