ChemicalBook >> CAS DataBase List >>(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- CAS No.
- 1448297-52-6
- Chemical Name:
- (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
- Synonyms
- MDK-7526;PROTACs Related Compound 1;133776;CPD1584;VH032-NH2;PROTAC-VHL-ligand;MDK7526(free base);(S,R,S)-AHPC (MDK7526);(S,R,S)-AHPC free base;(S,R,S)-AHPC (MDK7526) ，S0097
- CBNumber:
- CB23134090
- Molecular Formula:
- C22H30N4O3S
- Molecular Weight:
- 430.56
- MDL Number:
- MFCD29049827
- MOL File:
- 1448297-52-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 00:17:12
| Product description | Number | Pack Size | Price |
| (S,R,S)-AHPC (MDK7526) | YHC29752 | 5g | $649 |
| (S,R,S)-AHPC (MDK7526) | YHC29752 | 10g | $908.6 |
| (S,R,S)-AHPC (MDK7526) | YHC29752 | 25g | $1427.75 |
| (S,R,S)-AHPC (MDK7526) | YHC29752 | 50g | $2206.5 |
| (S,R,S)-AHPC (MDK7526) | YHC29752 | 100g | $4154 |
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Properties
| Boiling point | 691.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.254±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 14.10±0.40(Predicted) |
| form | Solid |
| color | White to light yellow |
| InChIKey | ZLOXMSNKPDWMEF-ZIFCJYIRSA-N |
| SMILES | C(NCC1=CC=C(C2SC=NC=2C)C=C1)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | YHC29752 | (S,R,S)-AHPC (MDK7526) | 1448297-52-6 | 5g | $649 | 2026-06-05 | Buy |
| Biosynth | YHC29752 | (S,R,S)-AHPC (MDK7526) | 1448297-52-6 | 10g | $908.6 | 2026-06-05 | Buy |
| Biosynth | YHC29752 | (S,R,S)-AHPC (MDK7526) | 1448297-52-6 | 25g | $1427.75 | 2026-06-05 | Buy |
| Biosynth | YHC29752 | (S,R,S)-AHPC (MDK7526) | 1448297-52-6 | 50g | $2206.5 | 2026-06-05 | Buy |
| Biosynth | YHC29752 | (S,R,S)-AHPC (MDK7526) | 1448297-52-6 | 100g | $4154 | 2026-06-05 | Buy |
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Chemical Properties,Uses,Production
Uses
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells[1].
Definition
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
IC 50
VHL
References
[1] Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019. DOI:10.1158/0008-5472.CAN-19-1236
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Suppliers
Global( 126)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 14014 | 58 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| NINGBOBENKANGJS PHARMTECHCO., LTD | +8615990591583 15990591583 | CHINA | 2029 | 58 | |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
View Lastest Price from (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-22 | (S,R,S)-AHPC
1448297-52-6
|
$85.00-198.00 | 99.64% | 10g | TargetMol Chemicals Inc. |
-
- (S,R,S)-AHPC
1448297-52-6
- $85.00-198.00
- 99.64%
- TargetMol Chemicals Inc.
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide Spectrum
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
3-Methyl-L-valyl-(4R)-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)benzyl]-L-prolinamide
(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrro
PROTAC-VHL-ligand
(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
CPD1584
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide HCl
133776
MDK7526(free base)
VH032-NH2
L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy- N-(
(4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-Prolinamide
(S,R,S)-AHPC (MDK7526)
(4R)-3-Methyl-L-valyl-4-hydroxy-N-4-(4-methyl-thiazol-5-yl)phenylmethyl-L-prolinamide
VH032-NH2|||MDK7526|||VHL ligand 1
(S,R,S)-AHPC free base
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide HCL SALT FORM
(S,R,S)-AHPC (MDK7526) ，S0097
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide - [AC80519]
MDK-7526
PROTACs Related Compound 1
1448297-52-6
C22H31ClN4O3S
