DBCO-NHS Ester
- CAS No.
- 1353016-71-3
- Chemical Name:
- DBCO-NHS Ester
- Synonyms
- DBCO-NHS;N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS ester;CAS_1353016-71-3;DBCO-CH2CH2COONHS;Dbco-nhs 98% 100mg;DBCO-NHS Ester (CCT-A133);DBCO-NHS ester, 10 mM in DMSO;DBCO-NHS Ester, ≥98% (CCT-1491);DBCO-NHS ester (DBCO NHS ester)
- CBNumber:
- CB23146567
- Molecular Formula:
- C23H18N2O5
- Molecular Weight:
- 402.4
- MDL Number:
- MFCD24386367
- MOL File:
- 1353016-71-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| DBCO-NHS ester ≥95% | 40461 | 25mg | $109 |
| DBCO-NHS ester ≥95% | 40461 | 50mg | $196 |
| DBCO-NHS ester ≥95% | 40461 | 100mg | $283 |
| DBCO-NHS ester ≥95% | 40461 | 250mg | $545 |
| DBCO-NHS Ester | TRC-D194965-50MG | 50mg | $371 |
| Boiling point | 670.2±65.0 °C(Predicted) |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Storage temp. -20°C |
| solubility | Soluble in DMSO, DCM, DMF |
| pka | -0.23±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| Appearance | White solid |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2 |
| InChIKey | XCEBOJWFQSQZKR-UHFFFAOYSA-N |
| SMILES | C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)ON1C(CCC1=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29339900 |
DBCO-NHS Ester price More Price(102)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 25mg | $109 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 50mg | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 100mg | $283 | 2026-04-30 | Buy |
| Cayman Chemical | 40461 | DBCO-NHS ester ≥95% | 1353016-71-3 | 250mg | $545 | 2026-04-30 | Buy |
| TRC | TRC-D194965-50MG | DBCO-NHS Ester | 1353016-71-3 | 50mg | $371 | 2026-06-03 | Buy |
DBCO-NHS Ester Chemical Properties,Uses,Production
Description
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.
IC 50
Cleavable Linker
DBCO-NHS Ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
DBCO-NHS Ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9612 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 |
| Supplier | Advantage |
|---|---|
| 9i LLC | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| Accela ChemBio Inc. | 58 |
| BOC Sciences | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| Wuhan Borenpharm Co., Ltd | 58 |
| Career Henan Chemica Co | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| GL Biochem (Shanghai) Ltd. | 58 |
View Lastest Price from DBCO-NHS Ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-10 | DBCO-NHS Ester
1353016-71-3
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-06 | DBCO-NHS ester
1353016-71-3
|
$30.00-76.00 | 99.04% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-07 | DBCO-NHS ester
1353016-71-3
|
100mg | >99.00% | 1g | Xian confluore Biological Technology Co., Ltd. |
-
- DBCO-NHS Ester
1353016-71-3
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- DBCO-NHS ester
1353016-71-3
- $30.00-76.00
- 99.04%
- TargetMol Chemicals Inc.
-
- DBCO-NHS ester
1353016-71-3
- $0.00
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
