L-Cysteine methyl ester hydrochloride
- CAS No.
- 18598-63-5
- Chemical Name:
- L-Cysteine methyl ester hydrochloride
- Synonyms
- H-Cys-Ome;Methyl L-Cysteinate Hydrochloride;(R)-Cysteine Methyl Ester Hydrochloride;MECYSTEINE HYDROCHLORIDE;Methyl cysteinate hydrochloride;L-Cysteine Methyl ester hydrochloride 98%;actiol;l.j.48;zeotin;acdrile
- CBNumber:
- CB2327369
- Molecular Formula:
- C4H10ClNO2S
- Molecular Weight:
- 171.65
- MDL Number:
- MFCD00038985
- MOL File:
- 18598-63-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| L-Cysteine methyl ester hydrochloride 98% | 410209 | 5g | $56.6 |
| L-Cysteine methyl ester hydrochloride 98% | 410209 | 25g | $83.2 |
| L-Cysteine Methyl Ester Hydrochloride >99.0%(T) | C0577 | 5g | $17 |
| L-Cysteine Methyl Ester Hydrochloride >99.0%(T) | C0577 | 25g | $32 |
| Mecysteine (hydrochloride) ≥95% | 34847 | 10g | $36 |
| More product size | |||
| Melting point | 142 °C (dec.)(lit.) |
|---|---|
| alpha | -2.25 º (c=5, 1 N HCl) |
| Density | 1.232 (estimate) |
| refractive index | -2.5 ° (C=20, MeOH) |
| FEMA | 4781 | L-CYSTEINE METHYL ESTER HYDROCHLORIDE |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol, Water (Slightly) |
| form | Crystalline Powder |
| color | White |
| biological source | synthetic |
| optical activity | [α]20/D 1.8°, c = 10 in methanol |
| Water Solubility | Soluble in water |
| Merck | 13,5809 |
| JECFA Number | 2270 |
| BRN | 3685824 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application | peptide synthesis |
| InChI | 1S/C4H9NO2S.ClH/c1-7-4(6)3(5)2-8;/h3,8H,2,5H2,1H3;1H/t3-;/m0./s1 |
| InChIKey | WHOHXJZQBJXAKL-DFWYDOINSA-N |
| SMILES | Cl[H].COC(=O)[C@@H](N)CS |
| CAS DataBase Reference | 18598-63-5(CAS DataBase Reference) |
| FDA UNII | 33RG619160 |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | HA2460000 | |||||||||
| F | 1-10 | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
L-Cysteine methyl ester hydrochloride price More Price(109)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 410209 | L-Cysteine methyl ester hydrochloride 98% | 18598-63-5 | 5g | $56.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 410209 | L-Cysteine methyl ester hydrochloride 98% | 18598-63-5 | 25g | $83.2 | 2026-04-30 | Buy |
| TCI Chemical | C0577 | L-Cysteine Methyl Ester Hydrochloride >99.0%(T) | 18598-63-5 | 5g | $17 | 2023-06-20 | Buy |
| TCI Chemical | C0577 | L-Cysteine Methyl Ester Hydrochloride >99.0%(T) | 18598-63-5 | 25g | $32 | 2022-04-27 | Buy |
| Cayman Chemical | 34847 | Mecysteine (hydrochloride) ≥95% | 18598-63-5 | 10g | $36 | 2026-04-30 | Buy |
L-Cysteine methyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
Mucolytic agent
Uses
A mucolytic. An effective drug for the treatment of liver failure. Shown to effectively inhibit the binding of ethynylestradiol metabolites to protein and nucleic acids.
Uses
L-Cysteine methyl ester hydrochloride is a biochemical shown to inhibit binding of ethynylestradiol metabolites to protein and nucleic acids. It used in the synthesis of peptides, Preparation of thiazolidine-4-carboxylates with carbonyl compounds.
Definition
ChEBI: Mecysteine hydrochloride is an alpha-amino acid ester.
Preparation
L-Cysteine methyl ester hydrochloride is prepared by esterification of L-cysteine hydrochloride monohydrate with methanol in the presence of hydrogen chloride.
reaction suitability
reaction type: solution phase peptide synthesis
Trade name
Acthiol (Joullié, France), Actiol (Lirca, Italy), Visclair (Sinclair, UK), Aslos-C (Nissin, J), Epectan (Seiko, Japan), Moltanine (Tohok.-Tokyo Tanabe, Japan), Radcol (Nippon Universal, Japan), Sekinin (Tokyo Hosei, Japan).
Synthesis
67-56-1
52-89-1
18598-63-5
3 mL of sulfoxide chloride (SOCl2) was slowly added dropwise to 35 mL of methanol under nitrogen protection in an ice bath. Subsequently, the reaction mixture was stirred at room temperature for 1 hour. After that, 1 g of L-cysteine hydrochloride monohydrate (Cys-HCl-H2O) was added to the above solution in batches. The reaction was continued with the mixed solution at room temperature for 3 hours and then heated to reflux for 1 hour. Upon completion of the reaction, the volatile components and solvent were removed by distillation under reduced pressure, and the resulting residue was recrystallized using a solvent mixture of methanol-dichloromethane (CH3OH-CH2Cl2) to give 0.84 g of the white solid product L-cysteine methyl ester hydrochloride in 85.9% yield. The product was analyzed by infrared spectroscopy (IR, KBr press) showing characteristic absorption peaks: 3040.4 cm-1 (strong, NH2 stretching vibration), 1709.7 cm-1 (strong, C=O stretching vibration), 2580 cm-1 (weak, SH stretching vibration). The nuclear magnetic resonance hydrogen spectrum (1H NMR, D2O as solvent, TMS as internal standard) data were as follows: δ 4.453 (t, 1H, CH, J = 5.2 Hz), 3.871 (s, 3H, CH3), 3.164 (t, 2H, CH2, J = 6.4 Hz). Elemental analysis results: Calculated values (C4H10NO2SCCl): C, 27.99%; H, 5.87%; N, 8.16%. Measured values: C, 28.11%; H, 6.01%; N, 8.08%.
References
[1] European Journal of Medicinal Chemistry, 2014, vol. 74, p. 199 - 215
[2] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4270 - 4277
[3] Tetrahedron Asymmetry, 2000, vol. 11, # 21, p. 4255 - 4261
[4] Journal of the American Chemical Society, 2008, vol. 130, # 15, p. 5052 - 5053
[5] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 176 - 187,12
L-Cysteine methyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3796 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +8618382028708 | ni@enlaibio.com | China | 1103 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6366 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 964 | 58 | |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
View Lastest Price from L-Cysteine methyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | L-Cysteine methyl ester hydrochloride
18598-63-5
|
1KG | 98%min | 500kgs | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-27 | H-L-Cys-OMe.HCl
18598-63-5
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-07-15 | L-Cysteine methyl ester hydrochloride
18598-63-5
|
$29.00 | 99.91% | 10g | TargetMol Chemicals Inc. |
-
- L-Cysteine methyl ester hydrochloride
18598-63-5
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- H-L-Cys-OMe.HCl
18598-63-5
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Cysteine methyl ester hydrochloride
18598-63-5
- $29.00
- 99.91%
- TargetMol Chemicals Inc.
