m-(Trifluoromethyl)phenylacetic acid
- CAS No.
- 351-35-9
- Chemical Name:
- m-(Trifluoromethyl)phenylacetic acid
- Synonyms
- 2-(3-(TRIFLUOROMETHYL)PHENYL)ACETIC ACID;3-(TRIFLUOROMETHYL)PHENYLACETIC ACID;2-(3-(TRIFLUOROMET;TIMTEC-BB SBB000433;RARECHEM AL BO 0127;m-(Trifluoromethyl)p;Inter-trifluoroMethyl acid;3-(TriflurorMethyl)benzylbroMide;3-TRIFLUOROMETHYPHENYLACETIC ACID;3-(Carboxymethyl)benzotrifluoride
- CBNumber:
- CB2336956
- Molecular Formula:
- C9H7F3O2
- Molecular Weight:
- 204.15
- MDL Number:
- MFCD00004339
- MOL File:
- 351-35-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-(Trifluoromethyl)phenylacetic acid 97% | 193356 | 10g | $120 |
| 3-(Trifluoromethyl)phenylacetic Acid >98.0%(T) | T1662 | 5g | $42 |
| 3-(Trifluoromethyl)phenylacetic Acid >98.0%(T) | T1662 | 25g | $167 |
| 3-(Trifluoromethyl)phenylacetic acid | FT46007 | 1kg | $900 |
| 3-(Trifluoromethyl)phenylacetic acid | FT46007 | 0.5kg | $900 |
| More product size | |||
| Melting point | 76-79 °C(lit.) |
|---|---|
| Boiling point | 238C/775Torr |
| Density | 1.357±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 4.14±0.10(Predicted) |
| color | White to Almost white |
| BRN | 2213223 |
| InChI | InChI=1S/C9H7F3O2/c10-9(11,12)7-3-1-2-6(4-7)5-8(13)14/h1-4H,5H2,(H,13,14) |
| InChIKey | BLXXCCIBGGBDHI-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC=CC(C(F)(F)F)=C1 |
| CAS DataBase Reference | 351-35-9(CAS DataBase Reference) |
| FDA UNII | FL2Q5QY24R |
| EPA Substance Registry System | Benzeneacetic acid, 3-(trifluoromethyl)- (351-35-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
m-(Trifluoromethyl)phenylacetic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 193356 | 3-(Trifluoromethyl)phenylacetic acid 97% | 351-35-9 | 10g | $120 | 2026-04-30 | Buy |
| TCI Chemical | T1662 | 3-(Trifluoromethyl)phenylacetic Acid >98.0%(T) | 351-35-9 | 5g | $42 | 2026-04-30 | Buy |
| TCI Chemical | T1662 | 3-(Trifluoromethyl)phenylacetic Acid >98.0%(T) | 351-35-9 | 25g | $167 | 2026-04-30 | Buy |
| Biosynth | FT46007 | 3-(Trifluoromethyl)phenylacetic acid | 351-35-9 | 1kg | $900 | 2026-06-04 | Buy |
| Biosynth | FT46007 | 3-(Trifluoromethyl)phenylacetic acid | 351-35-9 | 0.5kg | $900 | 2026-06-04 | Buy |
m-(Trifluoromethyl)phenylacetic acid Chemical Properties,Uses,Production
Chemical Properties
white to pale yellow crystalline powder
Uses
m-(Trifluoromethyl)phenylacetic acid is used as a reactant in a mechanistic study on ligand-accelerated C-H activation reactions.
Synthesis
2338-76-3
351-35-9
General procedure for the synthesis of [3-(trifluoromethyl)phenyl]acetic acid from [3-(trifluoromethyl)phenyl]acetonitrile: [3-(trifluoromethyl)phenyl]acetonitrile (5.4 g, 0.03 mol) was mixed with an aqueous solution of sodium hydroxide (6 g, 0.15 mol) and heated to reflux overnight. Upon completion of the reaction, it was cooled to room temperature and the pH of the reaction solution was adjusted with dilute hydrochloric acid to 2. Subsequently, the precipitate precipitated was collected by filtration, washed with water and dried to afford [3-(trifluoromethyl)phenyl]acetic acid as a white solid (5.2 g, 87% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 7.6 (m, 4H, aromatic hydrogen), 3.7 (s, 2H, CH2).
References
[1] Patent: WO2008/104524, 2008, A1. Location in patent: Page/Page column 49
[2] Journal of medicinal chemistry, 1968, vol. 11, # 6, p. 1258 - 1262
[3] Arzneimittel Forschung, 1965, vol. 15, p. 1251 - 1253
[4] Journal of the American Chemical Society, 1977, vol. 99, # 9, p. 3059 - 3067
[5] Journal of the American Chemical Society, 1982, vol. 104, # 7, p. 1937 - 1951
m-(Trifluoromethyl)phenylacetic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Xinchem Co., Ltd. | +86-021-34123252 +8618049800532 | xinchem@xinchem.com | China | 49 | 58 |
| Wuhan BJM Pharm Inc | 027-52341919 13545198479 | sales03@benjaminpharmchem.com | China | 584 | 58 |
| Shanghai Xinchem | +86-021-64606569 +8618049800532 | xinchem@vip.126.com | China | 2918 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3958 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from m-(Trifluoromethyl)phenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | m-(Trifluoromethyl)phenylacetic acid
351-35-9
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2024-05-30 | m-(Trifluoromethyl)phenylacetic acid
351-35-9
|
$1.00 | 1KG | 99% | 1KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-20 | m-(Trifluoromethyl)phenylacetic acid
351-35-9
|
$1.00 | 1KG | 95%~99% | 1ton | Career Henan Chemical Co |
-
- m-(Trifluoromethyl)phenylacetic acid
351-35-9
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- m-(Trifluoromethyl)phenylacetic acid
351-35-9
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- m-(Trifluoromethyl)phenylacetic acid
351-35-9
- $1.00
- 95%~99%
- Career Henan Chemical Co
m-(Trifluoromethyl)phenylacetic acid Spectrum
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