(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- CAS No.
- 22446-37-3
- Chemical Name:
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
- Synonyms
- Methyl 2-(2-hydroxyphenyl)acetate;Einecs 245-004-5;Methyl o-hydroxyphenylacetate;METHYL 2-HYDROXYPHENYL ACETATE;Methyl 2-hydroxybenzeneacetate;vMethyl 2-(2-hydroxyphenyl)acetate;2-Hydroxybenzeneacetic acid methyl ester;(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER;Benzeneacetic acid, 2-hydroxy-, methyl ester;Acetic acid, (o-hydroxyphenyl)-, methyl ester
- CBNumber:
- CB2403197
- Molecular Formula:
- C9H10O3
- Molecular Weight:
- 166.17
- MDL Number:
- MFCD00090077
- MOL File:
- 22446-37-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 2-(2-Hydroxyphenyl)acetate | TRC-M312795-5G | 5g | $214 |
| Methyl 2-(2-Hydroxyphenyl)acetate | TRC-M312795-1G | 1g | $65 |
| Methyl 2-(2-Hydroxyphenyl)acetate | TRC-M312795-100MG | 100mg | $59 |
| Methyl (2-hydroxyphenyl)acetate 97% | OR52466 | 250mg | $21 |
| Methyl (2-hydroxyphenyl)acetate 97% | OR52466 | 1g | $24 |
| More product size | |||
| Melting point | 122-124℃ |
|---|---|
| Boiling point | 115-120℃ (0.3 Torr) |
| Density | 1.181±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform, Methanol (Slightly) |
| form | Solid |
| pka | 9.55±0.30(Predicted) |
| color | Off-White to Light Brown |
| InChI | InChI=1S/C9H10O3/c1-12-9(11)6-7-4-2-3-5-8(7)10/h2-5,10H,6H2,1H3 |
| InChIKey | BVBSGGBDFJUSIH-UHFFFAOYSA-N |
| SMILES | C1(CC(OC)=O)=CC=CC=C1O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P261-P280 |
| HS Code | 2916399090 |
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-M312795-5G | Methyl 2-(2-Hydroxyphenyl)acetate | 22446-37-3 | 5g | $214 | 2026-06-03 | Buy |
| TRC | TRC-M312795-1G | Methyl 2-(2-Hydroxyphenyl)acetate | 22446-37-3 | 1g | $65 | 2026-06-03 | Buy |
| TRC | TRC-M312795-100MG | Methyl 2-(2-Hydroxyphenyl)acetate | 22446-37-3 | 100mg | $59 | 2026-06-03 | Buy |
| Apolloscientific | OR52466 | Methyl (2-hydroxyphenyl)acetate 97% | 22446-37-3 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR52466 | Methyl (2-hydroxyphenyl)acetate 97% | 22446-37-3 | 1g | $24 | 2026-06-04 | Buy |
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Chemical Properties,Uses,Production
Chemical Properties
It is white powdery crystal, m.p. 70～72℃, insoluble in water, soluble in benzene, toluene, acetone.
Uses
Methyl 2-(2-Hydroxyphenyl)acetate is used as a reactant in the preparation of caffeic acid phenylethyl esters as antiproliferative agents.
Definition
ChEBI: Methyl (2-hydroxyphenyl)acetate is a member of phenols.
Synthesis Reference(s)
Synthetic Communications, 24, p. 2743, 1994 DOI: 10.1080/00397919408010590
Synthesis
67-56-1
614-75-5
22446-37-3
Preparative Example 1A: Synthesis of methyl 2-hydroxyphenylacetate: o-hydroxyphenylacetic acid (400 g, 2.63 mmol) was dissolved in methanol (3.0 L), and the esterification reaction was carried out by passing hydrogen chloride gas into the solution. The reaction was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the reaction mixture was concentrated and dried under vacuum to afford the title compound 1A (415 g, 95% yield), the product was initially a yellow oil and solidified to a solid after standing overnight. The structure of the product was confirmed by 1H NMR (CDCl3, 400 MHz): δ 7.20-7.16 (m, 1H), 7.11-7.09 (m, 1H), 6.93-6.86 (m, 2H), 4.48 (br s, 1H), 3.74 (s, 2H), 3.69 (s, 3H).
References
[1] Organic and Biomolecular Chemistry, 2013, vol. 11, # 31, p. 5147 - 5155
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 21, p. 8948 - 8952
[3] Organic Letters, 2008, vol. 10, # 18, p. 3969 - 3972
[4] Patent: WO2015/102990, 2015, A1. Location in patent: Paragraph 0193-0195
[5] Journal of Organic Chemistry, 1994, vol. 59, # 1, p. 203 - 213
(2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2165 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8828 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-28 | (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
22446-37-3
|
1KG | 97% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2019-07-06 | (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
22446-37-3
|
$8.00 | 1KG | 99% | 10tons | Career Henan Chemical Co |
-
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
22446-37-3
- 97%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- (2-HYDROXY-PHENYL)-ACETIC ACID METHYL ESTER
22446-37-3
- $8.00
- 99%
- Career Henan Chemical Co
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