5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
- CAS No.
- 882670-69-1
- Chemical Name:
- 5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
- Synonyms
- 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline;5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER;5-Amino-2-methylphenylboronic acid pinacol ester 97%;4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anil...;4,4,5,5-TetraMethyl-2-(5-aMino-2-Methylphenyl)-1,3,2-dioxaborolane;4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine;4-Methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine;Benzenamine, 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen 5-amino-2-methylphenylboronate;5-Amino-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzenamine
- CBNumber:
- CB2444914
- Molecular Formula:
- C13H20BNO2
- Molecular Weight:
- 233.11
- MDL Number:
- MFCD05663859
- MOL File:
- 882670-69-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Amino-2-methylphenylboronic acid pinacol ester 97% | 706043 | 1g | $230 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | 093750 | 1.00g | $227 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | 093750 | 5.00g | $605 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 95+% | M57207 | 100mg | $13 |
| 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 95+% | M57207 | 250mg | $17 |
| More product size | |||
| Melting point | 82-86°C |
|---|---|
| Boiling point | 366.2±35.0 °C(Predicted) |
| Density | 1.03 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 5.01±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C13H20BNO2/c1-9-6-7-10(15)8-11(9)14-16-12(2,3)13(4,5)17-14/h6-8H,15H2,1-5H3 |
| InChIKey | HPNBWHDRLCVZFV-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(C)C(B2OC(C)(C)C(C)(C)O2)=C1 |
| UNSPSC Code | 12352103 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 |
| PPE | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-38-36 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 2 |
| HS Code | 2931900090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 706043 | 5-Amino-2-methylphenylboronic acid pinacol ester 97% | 882670-69-1 | 1g | $230 | 2023-01-07 | Buy |
| Matrix Scientific | 093750 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | 882670-69-1 | 1.00g | $227 | 2026-05-18 | Buy |
| Matrix Scientific | 093750 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | 882670-69-1 | 5.00g | $605 | 2026-05-18 | Buy |
| Synthonix | M57207 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 95+% | 882670-69-1 | 100mg | $13 | 2026-05-06 | Buy |
| Synthonix | M57207 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline 95+% | 882670-69-1 | 250mg | $17 | 2026-05-06 | Buy |
5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER Chemical Properties,Uses,Production
Synthesis
35944-64-0
73183-34-3
882670-69-1
Using 3-iodo-4-methylaniline (1.97 g, 8.45 mmol) and pinacol ester of bis(diphenylphosphino)borate (2.32 g, 9.13 mmol) as raw materials, pinacol ester of bis(boronic acid) was dissolved in DMSO (23 mL) under the protection of argon gas, and potassium acetate (2.87 g, 29.2 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride were added sequentially ( 345 mg, 0.423 mmol). The reaction mixture was stirred at 80 °C for 4 hours. After completion of the reaction, ethyl acetate and water were added to the mixture, the insoluble material was removed by filtration through diatomaceous earth and the organic phase was extracted with ethyl acetate. The organic layer was washed sequentially with water and brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=6/1) to afford the target product 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (Compound A4, 1.36 g, 69% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 1.33 (s, 12H), 2.42 (s, 3H), 3.51 (br s, 2H), 6.68 (dd, J = 8.1,2.7Hz, 1H), 6.97 (d, J = 8.1Hz, 1H), 7.11 (d, J = 2.7Hz, 1H).
References
[1] Patent: EP2269993, 2011, A1. Location in patent: Page/Page column 52
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 19, p. 5671 - 5686
[3] Patent: US2010/197688, 2010, A1. Location in patent: Page/Page column 16
[4] Patent: WO2015/24905, 2015, A1. Location in patent: Paragraph 00216-00217; 00344-00346
[5] Patent: US2015/80391, 2015, A1. Location in patent: Paragraph 0439; 0440; 0441; 0655; 0656; 0657
5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20120 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10457 | 58 |
View Lastest Price from 5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-09 | 5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
882670-69-1
|
$1.40-32.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd |
-
- 5-AMINO-2-METHYLPHENYLBORONIC ACID, PINACOL ESTER
882670-69-1
- $1.40-32.00
- 99%
- Henan Fengda Chemical Co., Ltd
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