1,4-Dichlorophthalazine
- CAS No.
- 4752-10-7
- Chemical Name:
- 1,4-Dichlorophthalazine
- Synonyms
- Dichlorophthalazine;1,4-Dichlorophtalazine;1,4-Dichloro-2,3-benzodiazine;1,4-Dichloropyrazine;1,4-DICHLOROPHALAZINE;1,4-DICHLOROPHTHALAZINE;Phthalazine, 1,4-dichloro-;1,4-Dichlorophthalazine>1,4-Dichlorophthalazine,98%;JR-8370, 1,4-Dichlorophthalazine, 97%
- CBNumber:
- CB2483520
- Molecular Formula:
- C8H4Cl2N2
- Molecular Weight:
- 199.04
- MDL Number:
- MFCD00006909
- MOL File:
- 4752-10-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1,4-Dichlorophthalazine 95% | 126020 | 5g | $185 |
| 1,4-Dichlorophthalazine 95% | 126020 | 1g | $44.6 |
| 1,4-Dichlorophthalazine >98.0%(GC) | D3749 | 1g | $38 |
| 1,4-Dichlorophthalazine >98.0%(GC) | D3749 | 5g | $113 |
| 1,4-Dichlorophthalazine | 158768 | 1g | $326 |
| More product size | |||
| Melting point | 160-162 °C (lit.) |
|---|---|
| Boiling point | 397.3±22.0 °C(Predicted) |
| Density | 1.486±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Chloroform, Methanol |
| pka | -0.44±0.30(Predicted) |
| form | Powder or Crystalline Powder |
| color | White to yellow |
| Water Solubility | Sparingly soluble in water.(0.26 g/L) (25°C), |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C8H4Cl2N2/c9-7-5-3-1-2-4-6(5)8(10)12-11-7/h1-4H |
| InChIKey | ODCNAEMHGMYADO-UHFFFAOYSA-N |
| SMILES | C1(Cl)C2=C(C=CC=C2)C(Cl)=NN=1 |
| CAS DataBase Reference | 4752-10-7(CAS DataBase Reference) |
| FDA UNII | 0OW60266KO |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
1,4-Dichlorophthalazine price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 126020 | 1,4-Dichlorophthalazine 95% | 4752-10-7 | 5g | $185 | 2026-04-30 | Buy |
| Sigma-Aldrich | 126020 | 1,4-Dichlorophthalazine 95% | 4752-10-7 | 1g | $44.6 | 2023-06-20 | Buy |
| TCI Chemical | D3749 | 1,4-Dichlorophthalazine >98.0%(GC) | 4752-10-7 | 1g | $38 | 2026-04-30 | Buy |
| TCI Chemical | D3749 | 1,4-Dichlorophthalazine >98.0%(GC) | 4752-10-7 | 5g | $113 | 2026-04-30 | Buy |
| Usbiological | 158768 | 1,4-Dichlorophthalazine | 4752-10-7 | 1g | $326 | 2026-06-03 | Buy |
1,4-Dichlorophthalazine Chemical Properties,Uses,Production
Uses
1,4-Dichlorophthalazine was used as starting reagent in the synthesis of series of 4-aryl-1-(4-methylpiperazin-1-yl)phthalazines. It was used as coupling reagent in the synthesis of novel soluble polymer-bound ligand. It was often used as building block in medicinal chemistry synthesis.
Uses
1,4-Dichlorophthalazine Oftens used building block in medicinal chemistry synthesis.1,2
Synthesis Reference(s)
Canadian Journal of Chemistry, 43, p. 2708, 1965 DOI: 10.1139/v65-379
Synthesis
1445-69-8
4752-10-7
General procedure for the synthesis of 1,4-dichlorophthalazine from phthaloyl hydrazine: phthaloyl hydrazine (1.68 g, 10 mmol) was added to a stirred solution of phosphoryl chloride (15 ml). The mixture was heated to 110°C and kept for 1 hour. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature. The mixture was slowly added dropwise to crushed ice and stirred for 10 minutes. Subsequently, the mixture was filtered through a Brinell funnel. The filter cake was washed to neutrality with distilled water and dried in vacuum. 1,4-Dichlorophthalazine (1.85 g, 90.1% yield) was finally obtained as a white solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 4, p. 1236 - 1238
[2] European Journal of Medicinal Chemistry, 2014, vol. 85, p. 235 - 244
[3] Chemical Biology and Drug Design, 2013, vol. 81, # 5, p. 591 - 599
[4] New Journal of Chemistry, 2016, vol. 40, # 7, p. 6070 - 6076
[5] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 6, p. 1576 - 1579
1,4-Dichlorophthalazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 17389186172 | 1077@dideu.com | China | 3796 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Shanghai Rlavie Technology Co ltd | +86-021-67759270 +86-17717059219 | sales@rlavie.com | China | 1030 | 58 |
View Lastest Price from 1,4-Dichlorophthalazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-12 | 1,4-Dichlorophthalazine
4752-10-7
|
$1.00-22.00 | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-01-04 | 1,4-Dichlorophthalazine
4752-10-7
|
1g | 98%min | 200kgs/month | Shanghai Rlavie Technology Co ltd | ||
 |
2019-07-06 | 1,4-Dichlorophthalazine
4752-10-7
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- 1,4-Dichlorophthalazine
4752-10-7
- $1.00-22.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 1,4-Dichlorophthalazine
4752-10-7
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- 1,4-Dichlorophthalazine
4752-10-7
- $1.00
- 98%
- Career Henan Chemical Co
