Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

The tumor necrosis factor receptor family, which includes TNF-RI, Fas, DR3, DR4, DR5, and DR6, plays an important role in the regulation of apoptosis in various physiological systems. The receptors are activated by a family of cytokines that include TNF, FasL, and TNF-related apoptosis-inducing ligand. They are characterized by a highly conserved extracellular region containing cysteine-rich repeats and a conserved intracellular region of about 80 amino acids termed the death domain. The DD is important for transducing the death signal by recruiting other DD containing adaptor proteins to the death-inducing signaling complex, resulting in activation of caspases.Death receptor signaling is also controlled by a family of decoy receptors which lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand. Expression of decoy receptors provide a mechanism for certain types of cancer to regulate apoptosis and can contribute to chemosensitivity.

References

[1] Nagata, S. (1997) Cell 88, 355-65.
[2] Thorburn, A. (2004) Cell Signal 16, 139-44.
[3] Sheridan, J.P. et al. (1997) Science 277, 818-821.
[4] Marsters, S.A. et al. (1997) Curr. Biol. 7, 1003-1006.
[5] Pitti, R.M. et al. (1998) Nature 396, 699-703.
[6] Liu, X. et al. (2005) Cancer Res. 65, 9169-9175.
[7] Spalding, A.C. et al. (2002) Oncogene 21, 260-271.
[8] Bernard, D. et al. (2001) J. Biol. Chem. 276, 27322-27328.

Raw materials

Preparation Products