Source

Rabbit

Reactivity

Human;Monkey

Background

Signal transducing adaptor molecule 2 is a ubiquitously expressed STAM family adaptor protein and an integral component of the ESCRT-0 complex. Similar to STAM1, STAM2 possesses a single SH3 domain and an immunoreceptor tyrosine-based activation motif. Following activation of multiple growth factor and cytokine cell surface receptors, the STAM2 protein undergoes tyrosine phosphorylation and potentiates mitogenic signals driven by these receptors. Research studies demonstrate that STAM2 is localized to complexes containing Eps15, Hrs, and STAM1 proteins on early endosome membranes. A tandem, amino-terminal VHS domain and UIM motif within STAM2 facilitate STAM2 interaction with ubiquitinated cargo proteins, suggesting that this adaptor participates in the endosomal sorting of ubiquitinated proteins targeted for lysosomal degradation. Gene targeting studies have revealed an indispensible role for STAM2 in T-cell development.

References

[1] Endo, K. et al. (2000) FEBS Lett 477, 55-61.
[2] Pandey, A. et al. (2000) J Biol Chem 275, 38633-9.
[3] Mizuno, E. et al. (2003) Mol Biol Cell 14, 3675-89.
[4] Bache, K.G. et al. (2003) J Biol Chem 278, 12513-21.
[5] Takata, H. et al. (2000) Genes Cells 5, 57-69.
[6] Mizuno, E. et al. (2004) J Biochem 135, 385-96.
[7] Yamada, M. et al. (2002) Mol Cell Biol 22, 8648-58.

Raw materials

Preparation Products