Source

Rabbit

Reactivity

Human

Background

Epiregulin belongs to the epidermal growth factor family and is a ligand for the EGF receptor and ErbB4. The binding of EREG to homodimers, as well as heterodimers containing EGFR or ErbB4, leads to receptor activation and downstream signaling to promote cell growth and proliferation. In normal human tissue, moderate levels of EREG are expressed in the placenta and peripheral blood macrophages. Research studies have shown that EREG is expressed at high levels in numerous cancer cell lines, and EREG expression is correlated with primary cancer aggresiveness/metastases. In addition to its involvement in tumorigenesis, a variant of EREG has also been shown to be associated with tuberculosis susceptibility. EREG is synthesized as a ~30 kDa glycosylated membrane bound proepiregulin form and through subsequent proteolytic cleavage is processed to a 17 kDa C-terminal propeptide, and the 6kDa mature form of epiregulin.

References

[1] Olayioye, M.A. et al. (2000) EMBO J 19, 3159-67.
[2] Shelly, M. et al. (1998) J Biol Chem 273, 10496-505.
[3] Komurasaki, T. et al. (1997) Oncogene 15, 2841-8.
[4] Komurasaki, T. et al. (2002) Growth Factors 20, 61-9.
[5] Shirakata, Y. et al. (2000) J Biol Chem 275, 5748-53.
[6] Toyoda, H. et al. (1995) J Biol Chem 270, 7495-500.
[7] Toyoda, H. et al. (1997) Biochem J 326 ( Pt 1), 69-75.
[8] Zhu, Z. et al. (2000) Biochem Biophys Res Commun 273, 1019-24.
[9] Kuramochi, H. et al. (2012) BMC Cancer 12, 88.
[10] Zhang, J. et al. (2008) Cancer Prev Res (Phila) 1, 201-7.

Raw materials

Preparation Products