Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

The serum response factor is a 67 kDa phospho-protein that, together with auxiliary factors, modulates transcription of immediate early genes containing serum response elements at their promoters. SRF contains several phosphorylation sites, but functional consequences of phosphorylation have not been identified unequivocally. Several growth factor- and calcium-regulated kinases, such as p90RSK and CaM kinase IV, can phosphorylate SRF at Ser103, and Ser103 of SRF is also a nuclear target for MAPKAP kinase 2.

References

[1] Treisman, R. (1995) EMBO J 14, 4905-13.
[2] Janknecht, R. et al. (1995) Carcinogenesis 16, 443-50.
[3] Marais, R.M. et al. (1992) EMBO J 11, 97-105.
[4] Rivera, V.M. et al. (1993) Mol Cell Biol 13, 6260-73.
[5] Miranti, C.K. et al. (1995) Mol Cell Biol 15, 3672-84.
[6] Heidenreich, O. et al. (1999) J Biol Chem 274, 14434-43.

Raw materials

Preparation Products