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Phospho-TACC3 (Ser558) Antibody

CAS No.
Chemical Name:
Phospho-TACC3 (Ser558) Antibody
Synonyms
Phospho-TACC3 (Ser558) Antibody
CBNumber:
CB26277390
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

Phospho-TACC3 (Ser558) Antibody Chemical Properties,Uses,Production

Source

Rabbit

Reactivity

Human

Background

Transforming acid coiled-coil proteins are a family of proteins characterized by a common coiled-coil motif of approximately 200 amino acids at the carboxy-terminal end. Three family members have been identified in humans: TACC1, TACC2, and TACC3. These proteins are thought to be involved in centrosomal microtubule assembly and have been mapped to chromosomal regions that are disrupted in some cancers. TACC3 has been shown to be upregulated in many cancer cell lines. When phosphorylated at Ser558 by Aurora A, mammalian TACC3 is localized to mitotic spindles and increases microtubule stability. For this reason, it has been suggested that monitoring the localization of phosphorylated TACC3 would be an effective way to determine the efficacy of Aurora A inhibitors that show promise as anti-cancer drugs. In addition, studies have shown that TACC3 could be useful as a prognostic marker for non-small cell lung cancer.

References

[1] Gergely, F. et al. (2000) Proc Natl Acad Sci USA 97, 14352-7.
[2] Peset, I. and Vernos, I. (2008) Trends Cell Biol 18, 379-88.
[3] Still, I.H. et al. (1999) Genomics 58, 165-170.
[4] Kinoshita, K. et al. (2005) J Cell Biol 170, 1047-55.
[5] Schneider, L. et al. (2007) J Biol Chem 282, 29273-83.
[6] LeRoy, P.J. et al. (2007) Cancer Res 67, 5362-70.
[7] Tyler, R.K. et al. (2007) Cell Cycle 6, 2846-54.
[8] Jung, C.K. et al. (2006) Pathol Int 56, 503-9.

Phospho-TACC3 (Ser558) Antibody Preparation Products And Raw materials

Raw materials

Preparation Products

Phospho-TACC3 (Ser558) Antibody Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
Enzo Biochem Inc Enzo Biochem Inc. 13797054060 Enzoname@qq.com China 6174 58
Cell Signaling Technology Inc 21-80243558 86218024 info@cellsignal.cn China 6427 58
Shanghai Haoye Biotechnology Co., Ltd. 15121098156 CHINA 6534 58
Hangzhou Shitu Biotechnology Co., Ltd. 17757146756 CHINA 3162 58
Guangzhou Bingheng Biotechnology Co., Ltd. 13631342304 CHINA 6888 58
Guangzhou Zhuanyan Biotechnology Co., Ltd. 18926165828 CHINA 6897 58
Guangzhou Leyan Biotechnology Co., Ltd. 15096011602 CHINA 6026 58
Phospho-TACC3 (Ser558) Antibody
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