1-Phenylcyclobutanecarbonitrile
- CAS No.
- 14377-68-5
- Chemical Name:
- 1-Phenylcyclobutanecarbonitrile
- Synonyms
- 1-Phenylcyclobutane-1-carbonitrile;Cyclobutanecarbonitrile, 1-phenyl-;1-PHENYLCYCLOBUTANECARBONITRILE;1-Phenylcyclobutanecarbonitrile>1-Phenylcyclobutanecarbonitrile,95%;1-PHENYLCYCLOBUTANECARBONITRILE 95%;1-Phenylcyclobutanecarbonitrile, 95% 5GR;1-Phenylcyclobutanecarbonitrile, 95% 25GR
- CBNumber:
- CB2666033
- Molecular Formula:
- C11H11N
- Molecular Weight:
- 157.21
- MDL Number:
- MFCD00019258
- MOL File:
- 14377-68-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-PHENYLCYCLOBUTANECARBONITRILE AldrichCPR | S462268 | 1 unit | $197 |
| 1-Phenylcyclobutanecarbonitrile >98.0%(GC) | P2252 | 5g | $63 |
| 1-Phenylcyclobutanecarbonitrile >98.0%(GC) | P2252 | 25g | $216 |
| 1-Phenyl-cyclobutanecarbonitrile 95% | OR346591 | 250mg | $24 |
| 1-Phenyl-cyclobutanecarbonitrile 95% | OR346591 | 500mg | $28 |
| More product size | |||
| Boiling point | 85°C/0.3mmHg(lit.) |
|---|---|
| Density | 1.03 |
| refractive index | 1.5313-1.5333 |
| storage temp. | Sealed in dry,Room Temperature |
| form | Liquid |
| color | Clear light yellow |
| FDA UNII | QUW28NRN8Z |
| NIST Chemistry Reference | Cyclobutanecarbonitrile, 1-phenyl-(14377-68-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P363-P403+P233-P405-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 36/37/39-26 | |||||||||
| HS Code | 29269095 | |||||||||
| NFPA 704 |
|
1-Phenylcyclobutanecarbonitrile price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S462268 | 1-PHENYLCYCLOBUTANECARBONITRILE AldrichCPR | 14377-68-5 | 1 unit | $197 | 2026-04-30 | Buy |
| TCI Chemical | P2252 | 1-Phenylcyclobutanecarbonitrile >98.0%(GC) | 14377-68-5 | 5g | $63 | 2026-04-30 | Buy |
| TCI Chemical | P2252 | 1-Phenylcyclobutanecarbonitrile >98.0%(GC) | 14377-68-5 | 25g | $216 | 2026-04-30 | Buy |
| Apolloscientific | OR346591 | 1-Phenyl-cyclobutanecarbonitrile 95% | 14377-68-5 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR346591 | 1-Phenyl-cyclobutanecarbonitrile 95% | 14377-68-5 | 500mg | $28 | 2026-06-04 | Buy |
1-Phenylcyclobutanecarbonitrile Chemical Properties,Uses,Production
Chemical Properties
CLEAR LIGHT YELLOW LIQUID
Uses
1-Phenylcyclobutanecarbonitrile is used as a reactant in the preparation of a novel diacylglycerol acyltransferase-1 (DGAT-1) inhibitor.
Synthesis
140-29-4
109-64-8
14377-68-5
The general procedure for the synthesis of 1-phenylcyclobutanecarbonitrile from phenylacetonitrile and 1,3-dibromopropane was as follows: powdered potassium hydroxide (536 g, 9.56 mol, 5.6 eq.) was suspended in a solvent mixture of toluene (1.54 L) and water (154 mL) and heated to 45 °C. Subsequently, tetrabutylammonium bromide (28 g, 0.85 mol, 0.05 eq.) and 1,3-dibromopropane (379 g, 1.88 mol, 1.1 eq.) were added followed by the slow dropwise addition of a toluene (500 mL) solution of phenylacetonitrile (200 g, 1.7 mol, 1.0 eq.) over a period of 42 min. During the dropwise addition, the reaction temperature was raised to 95 °C and the mixture was heated to reflux after the dropwise addition was completed. The resulting pink slurry was stirred at reflux temperature for 1 h. The completion of the reaction was confirmed by HPLC analysis. The reaction mixture was cooled to 20-25 °C and filtered through a Celite pad. The solid residue was washed with toluene (1.0 L), and the combined filtrates were washed sequentially with water (2 × 300 mL) and brine (150 mL), dried over anhydrous magnesium sulfate and filtered, and concentrated to give the crude product 1-phenylcyclobutanecarbonitrile (263 g) as an orange oil. The crude product was purified by vacuum distillation (boiling point 105 °C/750 mT) to give 1-phenylcyclobutanecarbonitrile in colorless liquid form [140 g, yield 52%, purity 97.7% (AUC)]. The major impurity was identified as B2 (2.3% AUC) (see Example 9, Synthesis of B section for details).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 23, p. 3871 - 3874
[2] Journal of Organometallic Chemistry, 1993, vol. 448, # 1-2, p. 9 - 14
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7341 - 7348
[4] Patent: US2015/266876, 2015, A1. Location in patent: Paragraph 0160; 0161
[5] Patent: US2015/57443, 2015, A1. Location in patent: Paragraph 0247; 0248
1-Phenylcyclobutanecarbonitrile Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29792 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14303 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| GLR Innovations | -- | info@glrgroup.in | India | 4535 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24597 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
View Lastest Price from 1-Phenylcyclobutanecarbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-08 | 1-Phenylcyclobutanecarbonitrile
14377-68-5
|
$2.00 | 1KG | 99 | 100kg | Career Henan Chemical Co |
-
- 1-Phenylcyclobutanecarbonitrile
14377-68-5
- $2.00
- 99
- Career Henan Chemical Co
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