2-AMINO-5-FLUOROPHENOL
- CAS No.
- 53981-24-1
- Chemical Name:
- 2-AMINO-5-FLUOROPHENOL
- Synonyms
- EOS-61433;2-AMINO-5-FLUOROPHEN;5-Fluoro-2-aMinophenol;2-AMINO-5-FLUOROPHENOL;2-azanyl-5-fluoro-phenol;4-Fluoro-2-hydroxyaniline;2-Amino-5-fluorophenol98%;Phenol, 2-amino-5-fluoro-;2- aMino-5-difluoro phenol;2-Amino-5-fluorophenol 98%
- CBNumber:
- CB2716633
- Molecular Formula:
- C6H6FNO
- Molecular Weight:
- 127.12
- MDL Number:
- MFCD00671759
- MOL File:
- 53981-24-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Amino-5-fluorophenol >97.0%(GC) | A2300 | 1g | $28 |
| 2-Amino-5-fluorophenol >97.0%(GC) | A2300 | 5g | $90 |
| 2-Amino-5-fluorophenol Asreported | 260399 | 5g | $333 |
| 2-Amino-5-fluorophenol Asreported | 260399 | 10g | $446 |
| 2-Amino-5-fluorophenol Asreported | 260399 | 25g | $638 |
| More product size | |||
| Melting point | 38°C |
|---|---|
| Boiling point | 246.1±25.0 °C(Predicted) |
| Density | 1.347±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO, Methanol |
| pka | 8.76±0.10(Predicted) |
| form | Solid |
| color | Dark Beige |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C6H6FNO/c7-4-1-2-5(8)6(9)3-4/h1-3,9H,8H2 |
| InChIKey | IIDUNAVOCYMUFB-UHFFFAOYSA-N |
| SMILES | C1(O)=CC(F)=CC=C1N |
| CAS DataBase Reference | 53981-24-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H335 | |||||||||
| Precautionary statements | P280h-P305+P351+P338-P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29089990 | |||||||||
| NFPA 704 |
|
2-AMINO-5-FLUOROPHENOL price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2300 | 2-Amino-5-fluorophenol >97.0%(GC) | 53981-24-1 | 1g | $28 | 2026-04-30 | Buy |
| TCI Chemical | A2300 | 2-Amino-5-fluorophenol >97.0%(GC) | 53981-24-1 | 5g | $90 | 2026-04-30 | Buy |
| Usbiological | 260399 | 2-Amino-5-fluorophenol Asreported | 53981-24-1 | 5g | $333 | 2026-06-03 | Buy |
| Usbiological | 260399 | 2-Amino-5-fluorophenol Asreported | 53981-24-1 | 10g | $446 | 2026-06-03 | Buy |
| Usbiological | 260399 | 2-Amino-5-fluorophenol Asreported | 53981-24-1 | 25g | $638 | 2026-06-03 | Buy |
2-AMINO-5-FLUOROPHENOL Chemical Properties,Uses,Production
Chemical Properties
Dark Beige Solid
Uses
2-Amino-5-fluorophenol is a fluoroaniline metabolite. 2-Amino-5-fluorophenol is used as organic intermediate. To synthesize the intermediate (2-amino-5-fluorophenol-N, N, O-triacetic acid trimethyl ester) of indicator which used in the determination Mg2+ by NMR, three feasible reactions were experimentally carried out, such as alkaline hydrolysis, catalytic hydrogenation and esterification.
Synthesis
446-36-6
53981-24-1
The general procedure for the synthesis of 2-amino-5-fluorophenol from 5-fluoro-2-nitrophenol is as follows: 5-fluoro-2-nitrophenol (2.50 g, 15.9 mmol, commercially available from e.g., Aldrich) was dissolved in ethanol (50 ml), and 10% palladium-carbon catalyst (980 mg) was added for the hydrogenation reaction, which lasted for 1.5 hours. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated. The solid residue obtained was dissolved in ether, followed by addition of an equal volume of cyclohexane. The ether was removed by vacuum distillation at room temperature to give a light gray solid product. The product was filtered and washed with cyclohexane to give 2-amino-5-fluorophenol (1.90 g, 94% yield). Elemental analysis measured values: C, 56.4; H, 4.8; N, 10.9. theoretical values (C6H6FNO): C, 56.7; H, 4.8; N, 11.0%.
References
[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 24, p. 9742 - 9753
[2] Patent: WO2010/94643, 2010, A1. Location in patent: Page/Page column 46
[3] Patent: US5238908, 1993, A
[4] Patent: US5393735, 1995, A
[5] Chemistry - A European Journal, 2011, vol. 17, # 33, p. 9076 - 9082
2-AMINO-5-FLUOROPHENOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 9976 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from 2-AMINO-5-FLUOROPHENOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-AMINO-5-FLUOROPHENOL
53981-24-1
|
1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | 2-AMINO-5-FLUOROPHENOL
53981-24-1
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-AMINO-5-FLUOROPHENOL
53981-24-1
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-AMINO-5-FLUOROPHENOL
53981-24-1
- $1.00
- 99%
- Career Henan Chemical Co
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