1-(4-Fluorophenyl)piperazine
- CAS No.
- 2252-63-3
- Chemical Name:
- 1-(4-Fluorophenyl)piperazine
- Synonyms
- 1-(4-Fluorophenyl)piperazine, 98% 10GR;MONA-004;AKOS BBS-00003614;RARECHEM AH CK 0104;TIMTEC-BB SBB000218;LABOTEST-BB LT00053495;FLUOROPHENYL PIPERAZINE;p-Fluorophenylpiperazine;4-FLUOROPHENYLPIPERAZINE;N-(p-Fluorophenyl)piperazine
- CBNumber:
- CB2725068
- Molecular Formula:
- C10H13FN2
- Molecular Weight:
- 180.22
- MDL Number:
- MFCD00005960
- MOL File:
- 2252-63-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-(4-Fluorophenyl)piperazine | TRC-F595795-500MG | 500mg | $109 |
| 1-(4-Fluorophenyl)piperazine | 012386 | 1g | $403 |
| 1-(4-Fluorophenyl)piperazine free base | FF00578 | 1g | $2998.38 |
| 1-(4-Fluorophenyl)piperazine 98% | AA003253 | 1g | $11 |
| 1-(4-Fluorophenyl)piperazine 98% | AA003253 | 5g | $17 |
| More product size | |||
| Melting point | 30-33 °C (lit.) |
|---|---|
| Boiling point | 118-123 °C/0.1 mmHg (lit.) |
| Density | 1.0 |
| refractive index | 1.5585-1.5605 |
| Flash point | >230 °F |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid After Melting |
| pka | 8.93±0.10(Predicted) |
| color | Clear yellow |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| BRN | 610723 |
| InChI | 1S/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2 |
| InChIKey | AVJKDKWRVSSJPK-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)N2CCNCC2 |
| CAS DataBase Reference | 2252-63-3(CAS DataBase Reference) |
| FDA UNII | VML61BE244 |
| NIST Chemistry Reference | 1-(P-fluorophenyl)piperazine(2252-63-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T,C | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Toxic/Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
1-(4-Fluorophenyl)piperazine price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-F595795-500MG | 1-(4-Fluorophenyl)piperazine | 2252-63-3 | 500mg | $109 | 2026-06-03 | Buy |
| Usbiological | 012386 | 1-(4-Fluorophenyl)piperazine | 2252-63-3 | 1g | $403 | 2026-06-03 | Buy |
| Biosynth | FF00578 | 1-(4-Fluorophenyl)piperazine free base | 2252-63-3 | 1g | $2998.38 | 2026-06-04 | Buy |
| aablocks | AA003253 | 1-(4-Fluorophenyl)piperazine 98% | 2252-63-3 | 1g | $11 | 2026-05-28 | Buy |
| aablocks | AA003253 | 1-(4-Fluorophenyl)piperazine 98% | 2252-63-3 | 5g | $17 | 2026-05-28 | Buy |
1-(4-Fluorophenyl)piperazine Chemical Properties,Uses,Production
Chemical Properties
clear yellowish liquid after melting
Uses
1-(4-Fluorophenyl)piperazine is a major metabolite of Niaparazine, a sedative, hypnotic drug. Metabolites of Niaprazine occurred by N-dealkylation, N-dearylation, aromatic hydroxylation and N-oxidatio n.
Uses
1-(4-Fluorophenyl)piperazine was used in the synthesis of N,N-disubstituted piperazine. It is a major metabolite of niaparazine, a sedative, a hypnotic drug.
Application
This study[1] reports the conventional and microwave-assisted synthesis of some new hybrid molecules derived from 1-(4-fluorophenyl)piperazine. Some of them shows good biological activity.
Synthesis
Weighing 4-fluoroaniline 9.2mL (0.10mol), bis(2-chloroethyl)amine hydrochloride 17.85g (0.10mol) and diethylene glycol monomethyl ether 25mL in a 100mL three-necked flask, and placed in the reflux device equipped with a reflux device WBFY-201-type microcomputer microwave chemical reactor, reflux, the microwave radiation power of 800W, the reaction time is 3min. At the end of the reaction, the reaction solution was cooled and then distilled under reduced pressure to remove diethylene glycol monomethyl ether, and the solvent was recovered for use. The residue was added to a small amount of ethanol, add a certain amount of ether solution, to be clarified by the mixture, at this time, a large number of solids precipitated, the hydrochloride was dissolved in 30mL of water, the PH value was adjusted to 12 with 40% sodium hydroxide, ethyl acetate extraction for 2 times (2 40mL), and then washed with water and saturated saline respectively for 1 time, the organic layer was dried with anhydrous sodium sulfate, filtered, concentrated, and then obtained by distillation under reduced pressure 1- (4-fluorophenyl)piperazine light yellow liquid 13.97g, yield 77.6%.
References
[1] Ozdemir, S. B., Demirbas, N., Demirbas, A., Colak, N., & Ayaz, F. A. (2018). Design, Microwave-Assisted and Conventional Synthesis of New Hybrid Compounds Derived From 1-(4-Fluorophenyl)piperazine and Screening for Their Biological Activities. ChemistrySelect, 3 7, 2144–2151. https://doi.org/10.1002/slct.201800019
1-(4-Fluorophenyl)piperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Fanbo Pharmaceutical Technology Co., Ltd | 15832170903 | tina@gnchemicals.com | China | 264 | 58 |
| Hinova Pharma | +86-18190684138 +86-18190684138 | xhchen00241@hinovapharma.com | China | 61 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29812 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6366 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 +86-18958018566 | info@afinechem.com | China | 15079 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
View Lastest Price from 1-(4-Fluorophenyl)piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-(4-Fluorophenyl)piperazine
2252-63-3
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 1-(4-Fluorophenyl)piperazine
2252-63-3
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 1-(4-Fluorophenyl)piperazine
2252-63-3
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-(4-Fluorophenyl)piperazine
2252-63-3
- $1.00
- 99%
- Career Henan Chemical Co
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