Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
- CAS No.
- 3939-01-3
- Chemical Name:
- Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
- Synonyms
- METHYL 1-BENZYL-4-OXO-3-PIPERIDINECARBOXYLATE HYDROCHLORIDE;1-BENZYL-3-CARBOMETHOXY-4-PIPERIDONE HYDROCHLORIDE;methyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride;methyl 1-benzyl-4-oxopiperidin;1-Benzyl-3-(methoxycarbonyl)-4-oxopiperidine.;N-Benzyl-3-carbomethoxy-4-piperidonehydrochloride;methyl 1-benzyl-4-oxo-3-piperidinecarboxylate HCl;1-Benzyl-3-methoxycarbonyl-4-piperidonehydrochloride;1-benzyl-3-methoxycarbonyl-4-oxopiperidine hydrochloride;Methyl 1-benzy1-4-oxo-3-piperidine-carboxylate hydrochloride
- CBNumber:
- CB2775654
- Molecular Formula:
- C14H18ClNO3
- Molecular Weight:
- 283.75062
- MDL Number:
- MFCD00012799
- MOL File:
- 3939-01-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 227005 | 5G | $59.3 |
| Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 227005 | 25g | $218 |
| Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 227005 | 100g | $345 |
| Methyl 1-Benzyl-4-oxo-3-piperidinecarboxylate Hydrochloride >98.0%(HPLC) | M2531 | 5g | $24 |
| Methyl 1-Benzyl-4-oxo-3-piperidinecarboxylate Hydrochloride >98.0%(HPLC) | M2531 | 25g | $77 |
| More product size | |||
| Melting point | 185 °C (dec.)(lit.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| form | Crystalline Powder |
| color | White to pink |
| Sensitive | Hygroscopic |
| InChI | InChI=1S/C14H17NO3.ClH/c1-18-14(17)12-10-15(8-7-13(12)16)9-11-5-3-2-4-6-11;/h2-6,12H,7-10H2,1H3;1H |
| InChIKey | BRADBAOVPACOQQ-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=CC=C2)CCC(=O)C(C(OC)=O)C1.[H]Cl |
| CAS DataBase Reference | 3939-01-3(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P304+P340-P305+P351+P338-P312-P321 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 227005 | Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 3939-01-3 | 5G | $59.3 | 2025-07-31 | Buy |
| Sigma-Aldrich | 227005 | Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 3939-01-3 | 25g | $218 | 2023-06-20 | Buy |
| Sigma-Aldrich | 227005 | Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride 95% | 3939-01-3 | 100g | $345 | 2023-06-20 | Buy |
| TCI Chemical | M2531 | Methyl 1-Benzyl-4-oxo-3-piperidinecarboxylate Hydrochloride >98.0%(HPLC) | 3939-01-3 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | M2531 | Methyl 1-Benzyl-4-oxo-3-piperidinecarboxylate Hydrochloride >98.0%(HPLC) | 3939-01-3 | 25g | $77 | 2026-04-30 | Buy |
Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride Chemical Properties,Uses,Production
Chemical Properties
white to pink crystalline powder
Uses
Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate hydrochloride (1-Benzyl-3-carbomethoxy-4-piperidone hydrochloride) may be used in chemical synthesis.
Uses
Methyl 1-benzyl-4-oxo-3-piperidinecarboxylate, HCl
Synthesis
3612-20-2
616-38-6
3939-01-3
Step A: Synthesis of methyl 4-oxo-1-(phenylmethyl)-3-piperidinecarboxylate hydrochloride. A solution was prepared by dissolving 1-benzyl-4-piperidone (56.5 kg, 1.0 eq.) in toluene (189 L) at 15 °C to 25 °C. In another reactor, toluene (659L), potassium tert-butoxide (71.9 kg, 2.25 eq.) and dimethyl carbonate (51.5 kg, 2.0 eq.) were added at 15 °C to 25 °C to form a slurry. The slurry was heated to 80°C to 90°C. A toluene solution of 1-benzyl-4-piperidone was slowly added to the slurry over a period of 60 to 90 minutes. After 90 minutes of reaction, the mixture was cooled to below 15°C. The reaction was quenched with acetic acid (38.5 kg, 2.25 eq.) and water (367 L). The two phases were separated and the organic layer was filtered to remove solids. The organic filtrate was concentrated by distillation under reduced pressure to about 150 L. Toluene (799 L) was added to the concentrate and hydrogen chloride gas (11.0 kg, 1.05 eq.) was passed through to form a hydrochloride precipitate. The slurry was stirred at 10°C to 15°C for 30 minutes. The solid was collected by filtration, washed with hexane (~130 L) and dried under vacuum to give 79.4 kg of methyl 4-oxo-1-(phenylmethyl)-3-piperidinecarboxylate hydrochloride in 97.8% yield. Elemental analysis (C14H17NO3-HCl) Calculated values: C 59.3, H 6.39, N 4.94; measured values: C 59.7, H 6.65, N 4.85.
References
[1] Patent: EP1031575, 2000, A1
[2] Patent: US2002/2283, 2002, A1
Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9598 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29093 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
3939-01-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
3939-01-3
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
3939-01-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride
3939-01-3
- $1.00
- 98%
- Career Henan Chemical Co
