2-Bromo-3-nitrophenol
- CAS No.
- 101935-40-4
- Chemical Name:
- 2-Bromo-3-nitrophenol
- Synonyms
- 2-BroMo-3-nitropheno;2-BROMO-3-NITROPHENOL;Phenol, 2-broMo-3-nitro-;2-Bromo-3-nitrophenol 97+%;2-Bromo-3-nitrophenol, 95% (Custom work);(S)-1-phenyl-2-methoxyethylamine hydrochloride
- CBNumber:
- CB2823311
- Molecular Formula:
- C6H4BrNO3
- Molecular Weight:
- 218
- MDL Number:
- MFCD08704555
- MOL File:
- 101935-40-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 2-Bromo-3-nitrophenol 98% | AS36621 | 1g | $27 |
| 2-Bromo-3-nitrophenol 98% | AS36621 | 5g | $81 |
| 2-Bromo-3-nitrophenol 97% | OR70053 | 1g | $21 |
| 2-Bromo-3-nitrophenol 98% | AS36621 | 25g | $290 |
| 2-Bromo-3-nitrophenol 97% | OR70053 | 5g | $58 |
| More product size | |||
| Melting point | 147.5°C |
|---|---|
| Boiling point | 248°C |
| Density | 1.881 |
| refractive index | 1.6090 (estimate) |
| Flash point | 104°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | powder |
| pka | 7.39±0.25(Predicted) |
| color | Beige/brown |
| InChI | InChI=1S/C6H4BrNO3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H |
| InChIKey | HRVRWIBVVHOHNN-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=CC([N+]([O-])=O)=C1Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H317-H318-H410 |
| Precautionary statements | P261-P264-P270-P272-P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310-P333+P313-P391-P501 |
| HS Code | 2908990000 |
2-Bromo-3-nitrophenol price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS36621 | 2-Bromo-3-nitrophenol 98% | 101935-40-4 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS36621 | 2-Bromo-3-nitrophenol 98% | 101935-40-4 | 5g | $81 | 2026-06-04 | Buy |
| Apolloscientific | OR70053 | 2-Bromo-3-nitrophenol 97% | 101935-40-4 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS36621 | 2-Bromo-3-nitrophenol 98% | 101935-40-4 | 25g | $290 | 2026-06-04 | Buy |
| Apolloscientific | OR70053 | 2-Bromo-3-nitrophenol 97% | 101935-40-4 | 5g | $58 | 2026-06-04 | Buy |
2-Bromo-3-nitrophenol Chemical Properties,Uses,Production
Uses
In laboratory research and chemical synthesis, 2-bromo-3-nitrophenol is mainly used as a multifunctional organic synthesis intermediate and chiral structural unit.
Synthesis
603-85-0
101935-40-4
General procedure for the synthesis of 2-bromo-3-nitrophenol from 2-amino-3-nitrophenol: 2-amino-3-nitrophenol (5 g, 32.4 mmol) was dissolved in water (29.5 mL) and 1,4-dioxane (14.7 mL). The mixture was heated to reflux and hydrobromic acid (48%, 16.7 mL, 147 mmol) was added dropwise over 20 min. After addition, reflux was continued for 15 min. The reaction mixture was cooled to 0 °C (ice bath) and a solution of sodium nitrite (2.23 g, 32.3 mmol) in water (20 mL) was added over 30 min. Stirring was continued at 0 °C for 15 min, then the mixture was transferred to a pre-cooled jacketed dropping funnel (0 °C) and added dropwise to a stirred mixture of cuprous bromide (I) (5.34 g, 37.2 mmol) in water (29.5 mL) and hydrobromic acid (48%, 16.7 mL, 147 mmol). The reaction mixture was stirred at 0 °C for 15 min, then warmed to 60 °C, continued stirring for 15 min, cooled to room temperature, and stirred overnight. The reaction mixture was transferred to a partition funnel and extracted with ether (3 x 150 mL). The organic layers were combined, washed with brine (1 x 150 mL), dried (Na2SO3), filtered and concentrated to give the crude product (7.99 g) as a reddish brown oil. The crude product was extracted by fast column chromatography (1:25 ultrapure silica gel, 230-400 mesh, 40-60 mm, 60 ; CH2Cl2 as solvent) purified the crude product to afford pure 2-bromo-3-nitrophenol (45%, 3.16 g) as an orange-brown solid. Mass spectrum (MS) m/z: 217.8 (MH+). High performance liquid chromatography (HPLC, TFA) homogeneity at 220 nm: 97%.
References
[1] Chemistry - A European Journal, 2017, vol. 23, # 42, p. 9996 - 10000
[2] Patent: JP2005/522501, 2005, A. Location in patent: Page/Page column 18
[3] Patent: WO2009/92590, 2009, A2. Location in patent: Page/Page column 69-70
[4] Patent: WO2009/109539, 2009, A2. Location in patent: Page/Page column 65; 66
[5] Patent: WO2004/103996, 2004, A1. Location in patent: Page 40
2-Bromo-3-nitrophenol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 2-Bromo-3-nitrophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | 2-Bromo-3-nitrophenol
101935-40-4
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
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- 2-Bromo-3-nitrophenol
101935-40-4
- $1.00
- 99%
- Career Henan Chemical Co
