Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI)
![Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI) Structure](CAS/GIF/82353-56-8.gif)
- CAS No.
- 82353-56-8
- Chemical Name:
- Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- tert-butyl (R)-(1-oxopropan-2-yl)carbamate;Boc-D-alaninal;Boc-D-Ala-aldehyde;Boc-D-Ala-al;N-Boc-D-Alaninal;Boc-D-propanemaldehyde;N-tert-Butoxycarbonyl-D-alaninal;(R)-2-(tert-Butoxycarbonylamino)propanal;(R)-tert-Butyl (1-oxopropan-2-yl)carbamate;tert-butyl N-[(2R)-1-oxopropan-2-yl]carbamate
- CBNumber:
- CB31054302
- Molecular Formula:
- C8H15NO3
- Molecular Weight:
- 173.21
- MDL Number:
- MFCD00274183
- MOL File:
- 82353-56-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| tert-butyl N-[(2R)-1-oxopropan-2-yl]carbamate | HDA35356 | 2.5g | $531 |
| (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 301112 | 1.00g | $106 |
| (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 301112 | 5.00g | $426 |
| (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 301112 | 25.00g | $1440 |
| (R)-tert-Butyl (1-oxopropan-2-yl)carbamate 95% | AA00G4C5 | 100mg | $19 |
| Melting point | 86-87℃ |
|---|---|
| Boiling point | 249℃ |
| Density | 1.015 |
| Flash point | 104℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 11.43±0.46(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C8H15NO3/c1-6(5-10)9-7(11)12-8(2,3)4/h5-6H,1-4H3,(H,9,11)/t6-/m1/s1 |
| InChIKey | OEQRZPWMXXJEKU-ZCFIWIBFSA-N |
| SMILES | C(OC(C)(C)C)(=O)N[C@H](C)C=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI) price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | HDA35356 | tert-butyl N-[(2R)-1-oxopropan-2-yl]carbamate | 82353-56-8 | 2.5g | $531 | 2026-06-04 | Buy |
| Matrix Scientific | 301112 | (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 82353-56-8 | 1.00g | $106 | 2026-05-19 | Buy |
| Matrix Scientific | 301112 | (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 82353-56-8 | 5.00g | $426 | 2026-05-19 | Buy |
| Matrix Scientific | 301112 | (R)-tert-Butyl (1-oxopropan-2-yl)carbamate | 82353-56-8 | 25.00g | $1440 | 2026-05-19 | Buy |
| aablocks | AA00G4C5 | (R)-tert-Butyl (1-oxopropan-2-yl)carbamate 95% | 82353-56-8 | 100mg | $19 | 2026-05-28 | Buy |
Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Uses,Production
Synthesis
79069-13-9
![Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI)](/CAS/GIF/82353-56-8.gif)
82353-56-8
The general procedure for the synthesis of (R)-2-(tert-butoxycarbonylamino)propanal from N-Boc-L-alaninol was as follows: to a solution of oxalyl chloride (3.1 g, 24.5 mmol) in anhydrous dichloromethane (DCM, 200 mL) was slowly added dimethylsulfoxide (DMSO, 2.9 mL, 40.8 mmol) at -60 °C. The reaction mixture was stirred at this temperature for 30 minutes. Subsequently, a solution of tert-butyl (R)-(1-hydroxypropan-2-yl)carbamate (3.5 g, 20 mmol) in dichloromethane (DCM, 20 mL) was slowly added at -60 °C. The resulting solution continued to be stirred at -60°C for 30 minutes. Next, triethylamine (11.1 mL, 80 mmol) was added at -60 °C and the reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, water (100 mL) was added for quenching and the mixture was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate (Na2SO4), and the filtrate was filtered and concentrated to afford the target product (R)-2-(tert-butoxycarbonylamino)propanal (aldehyde 322) as a light yellow oil (3.2 g, 94% yield), which could be used in the subsequent steps without further purification.
References
[1] Chemistry - An Asian Journal, 2012, vol. 7, # 7, p. 1542 - 1545
[2] Patent: US2015/374858, 2015, A1. Location in patent: Paragraph 0500
[3] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 42
[4] Patent: US2009/36419, 2009, A1. Location in patent: Page/Page column 87
[5] Patent: WO2012/125887, 2012, A1. Location in patent: Page/Page column 173
Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
Carbamic acid, [(1R)-1-methyl-2-oxoethyl]-, 1,1-dimethylethyl ester (9CI) Suppliers
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