6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 107516-75-6
- Chemical Name:
- 6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Diethyl indole-2,6-dicarboxylate;Diethylindole-2,6-dicarboxylate,96%;Diethyl indole-2,6-dicarboxylate, 96%;1H-Indole-2,6-dicarboxylic acid diethyl ester;diethyl 1H-indole-2,6-dicarboxylate - [D81295];Indole-2,6-dicarboxylic acid diethyl ester, 96%;1H-Indole-2,6-dicarboxylic acid, 2,6-diethyl ester;6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
- CBNumber:
- CB3116515
- Molecular Formula:
- C14H15NO4
- Molecular Weight:
- 261.27
- MDL Number:
- MFCD03411566
- MOL File:
- Mol file
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| DIETHYL 1H-INDOLE-2,6-DICARBOXYLATE 97% | 52722 | 1G | $53 |
| DIETHYL 1H-INDOLE-2,6-DICARBOXYLATE 97% | 52722 | 5G | $147 |
| Diethyl 1H-indole-2,6-dicarboxylate | 307141 | 250.00mg | $38 |
| Diethyl 1H-indole-2,6-dicarboxylate | 307141 | 1.00g | $60 |
| Diethyl 1H-indole-2,6-dicarboxylate | 307141 | 5.00g | $245 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 52722 | DIETHYL 1H-INDOLE-2,6-DICARBOXYLATE 97% | 107516-75-6 | 1G | $53 | 2026-04-30 | Buy |
| AstaTech | 52722 | DIETHYL 1H-INDOLE-2,6-DICARBOXYLATE 97% | 107516-75-6 | 5G | $147 | 2026-04-30 | Buy |
| Matrix Scientific | 307141 | Diethyl 1H-indole-2,6-dicarboxylate | 107516-75-6 | 250.00mg | $38 | 2026-05-19 | Buy |
| Matrix Scientific | 307141 | Diethyl 1H-indole-2,6-dicarboxylate | 107516-75-6 | 1.00g | $60 | 2026-05-19 | Buy |
| Matrix Scientific | 307141 | Diethyl 1H-indole-2,6-dicarboxylate | 107516-75-6 | 5.00g | $245 | 2026-05-19 | Buy |
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Uses,Production
Uses
6-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is utilized in medicinal chemistry for the design and development of new drugs.
Synthesis
861384-91-0
107516-75-6
Synthesis of diethyl 1H-indole-2,6-dicarboxylate (3): ethyl 4-(3-ethoxy-2,3-dioxopropyl)-3-nitrobenzoate (2) (8.5 g, 27.5 mmol) was suspended in acetic acid (75 mL) and heated to 75°C. After the solid was completely dissolved, water (56 mL) was slowly added, followed by activated zinc powder (17.9 g, 27.5 mmol). 27.5 mmol). The reaction temperature was maintained at 80°C with continuous stirring for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ethyl acetate (50 mL) and filtered through a diatomaceous earth pad. The filtrate was washed sequentially with water (2 x 100 mL), saturated sodium bicarbonate solution (2 x 100 mL) and brine (100 mL). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to afford the yellow solid product 3 (6.0 g, 83% yield).1H NMR (500 MHz, DMSO-d6) δ 1.33 (m, 6H), 4.34 (m, 4H), 7.21 (s, 1H), 7.65 (d, J = 8.5 Hz, 1H), 7.75 (d, J = 8.5 Hz, 1H), 7.12 (s, 1H), 7.12 (s, 1H), 8.12 (s, 1H). 8.12 (s, 1H), 12.25 (s, 1H). Mass spectrum (MS) m/z (M-H): 259.9.
References
[1] Patent: WO2014/149164, 2014, A1. Location in patent: Paragraph 00802; 00826
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 9, p. 2588 - 2599
[3] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 3, p. 938 - 941
[4] Patent: US2006/276453, 2006, A1. Location in patent: Page/Page column 32-33
[5] Patent: WO2011/71716, 2011, A1. Location in patent: Page/Page column 40-41
6-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| CR Corporation Limited | fred.wen@crcorporation.cn | China | 8645 | 58 | |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Allfluoro pharmaceutical co. ltd. | +86-400-0216110 +86-15958047586 | sales@allfluoro.com | China | 11385 | 58 |
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