2-Cyano-3-chloropyridine
- CAS No.
- 38180-46-0
- Chemical Name:
- 2-Cyano-3-chloropyridine
- Synonyms
- 3-Chloropicolinonitrile;3-CHLORO-2-CYANOPYRIDINE;oro-2-cyanopyridine;2-Cyano-3-chloropyri;2-CYANO-3-CHLOROPYRIDINE;3-Chloro-2-cyanopyridine >3-Chloro-2-cyanopyridine ,95%;3-CHLOROPYRIDINE-2-CARBONITRILE;3-CHLORO-2-PYRIDINECARBONITRILE;2-Pyridinecarbonitrile, 3-chloro-
- CBNumber:
- CB3127818
- Molecular Formula:
- C6H3ClN2
- Molecular Weight:
- 138.55
- MDL Number:
- MFCD03788834
- MOL File:
- 38180-46-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-Chloro-2-cyanopyridine >98.0%(GC) | C3022 | 1g | $19 |
| 3-Chloro-2-cyanopyridine >98.0%(GC) | C3022 | 5g | $42 |
| 2-Cyano-3-chloropyridine (3-Chloro-2-cyanopyridine) | C8397-02 | 250mg | $425 |
| 2-Cyano-3-chloropyridine | TRC-C962500-2G | 2g | $490 |
| 2-Cyano-3-chloropyridine | TRC-C962500-250MG | 250mg | $78 |
| More product size | |||
| Melting point | 81-83°C |
|---|---|
| Boiling point | 100°C/3mmHg(lit.) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol |
| pka | -2.60±0.10(Predicted) |
| form | Solid |
| color | Light Yellow |
| InChI | InChI=1S/C6H3ClN2/c7-5-2-1-3-9-6(5)4-8/h1-3H |
| InChIKey | YDPLFBIGFQFIDB-UHFFFAOYSA-N |
| SMILES | C1(C#N)=NC=CC=C1Cl |
| CAS DataBase Reference | 38180-46-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H315-H319-H332-H335-H301 | |||||||||
| Precautionary statements | P301+P310-P280h-P305+P351+P338-P309-P310 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25-36/37/38-20/21/22 | |||||||||
| Safety Statements | 45-36/37-22 | |||||||||
| RIDADR | 2811 | |||||||||
| HazardClass | 6.1 | |||||||||
| HazardClass | IRRITANT-HARMFUL | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29333990 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Cyano-3-chloropyridine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3022 | 3-Chloro-2-cyanopyridine >98.0%(GC) | 38180-46-0 | 1g | $19 | 2026-04-30 | Buy |
| TCI Chemical | C3022 | 3-Chloro-2-cyanopyridine >98.0%(GC) | 38180-46-0 | 5g | $42 | 2026-04-30 | Buy |
| Usbiological | C8397-02 | 2-Cyano-3-chloropyridine (3-Chloro-2-cyanopyridine) | 250mg | $425 | 2026-06-03 | Buy | |
| TRC | TRC-C962500-2G | 2-Cyano-3-chloropyridine | 38180-46-0 | 2g | $490 | 2026-06-03 | Buy |
| TRC | TRC-C962500-250MG | 2-Cyano-3-chloropyridine | 38180-46-0 | 250mg | $78 | 2026-06-03 | Buy |
2-Cyano-3-chloropyridine Chemical Properties,Uses,Production
Chemical Properties
Light Yellow Solid
Uses
2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.
Synthesis
7677-24-9
38180-46-0
3-Chloro-2-cyanopyridine (44A, 2.59 g, 20 mmol) was used as starting material and mixed with trimethylmethylsilyl cyanide (5.95 g, 60 mmol), triethylamine (Et3N, 4.05 g, 40 mmol), and acetonitrile (20 mL) in a 250 mL three-necked round-bottom flask. The reaction mixture was refluxed under nitrogen protection for 6 h. Complete consumption of raw materials was confirmed by HPLC analysis. Upon completion of the reaction, the cooled reaction mixture was concentrated under reduced pressure to give a brown semi-solid. The semi-solid was extracted by partitioning with 3N Na2CO3 aqueous solution and dichloromethane (CH2Cl2). The organic layer was washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The resulting residue was purified by fast chromatography using 5% ether (Et2O)/dichloromethane (CH2Cl2) as eluent, and the target product 44B was finally obtained as a white crystalline solid (1.84 g, 67% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 7.37 (dd, J = 4.7, 8.4 Hz, 1H), 7.73 (dd, J = 1.4, 8.2 Hz, 1H), 8.47 (dd, J = 1.3, 4.6 Hz, 1H); LC/MS analysis showed m/z 139 [M + H]+.
References
[1] Patent: US2004/19063, 2004, A1
[2] Patent: US2004/181064, 2004, A1
2-Cyano-3-chloropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 |
View Lastest Price from 2-Cyano-3-chloropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Cyano-3-chloropyridine
38180-46-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-19 | 2-Cyano-3-chloropyridine
38180-46-0
|
$3.00 | 1KG | 98% | 1kg,5kg,50kg | Career Henan Chemical Co | |
 |
2020-01-03 | 2-Cyano-3-chloropyridine | $1.00 | 1KG | 99% | 10000KGS | Career Henan Chemical Co |
-
- 2-Cyano-3-chloropyridine
38180-46-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Cyano-3-chloropyridine
38180-46-0
- $3.00
- 98%
- Career Henan Chemical Co
-
- 2-Cyano-3-chloropyridine
- $1.00
- 99%
- Career Henan Chemical Co
