(R)-2-Amino-3-methoxylpropanoic acid
- CAS No.
- 86118-11-8
- Chemical Name:
- (R)-2-Amino-3-methoxylpropanoic acid
- Synonyms
- D-Ser(me);H-D-Ser(Me)-OH;H-D-OMe-Ser-OH;D-O-Methylserine;O-methyl-d-ser hcl;D-Serine, O-methyl-;O-Methyl-D-Serine·HCl;O-Methyl-D-serine,97%;O-Methyl-D-Ser hydrochloride;D-O-methylserine Hydrochlorate
- CBNumber:
- CB31479718
- Molecular Formula:
- C4H9NO3
- Molecular Weight:
- 119.12
- MDL Number:
- MFCD08063275
- MOL File:
- 86118-11-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-2-Amino-3-methoxylpropanoic acid | 132114 | 5.00g | $450 |
| (R)-2-Amino-3-methoxylpropanoic acid | 132114 | 25.00g | $1437 |
| (R)-2-Amino-3-methoxypropanoic acid >98% | A61058 | 1g | $40 |
| (R)-2-Amino-3-methoxypropanoic acid >98% | A61058 | 5g | $110 |
| (R)-2-Amino-3-methoxypropanoic acid >98% | A61058 | 10g | $200 |
| More product size | |||
| Boiling point | 260.6±30.0 °C(Predicted) |
|---|---|
| Density | 1.195±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 2.10±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C4H9NO3/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 |
| InChIKey | KNTFCRCCPLEUQZ-GSVOUGTGSA-N |
| SMILES | C(O)(=O)[C@@H](COC)N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
(R)-2-Amino-3-methoxylpropanoic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 132114 | (R)-2-Amino-3-methoxylpropanoic acid | 86118-11-8 | 5.00g | $450 | 2026-05-18 | Buy |
| Matrix Scientific | 132114 | (R)-2-Amino-3-methoxylpropanoic acid | 86118-11-8 | 25.00g | $1437 | 2026-05-18 | Buy |
| Synthonix | A61058 | (R)-2-Amino-3-methoxypropanoic acid >98% | 86118-11-8 | 1g | $40 | 2026-05-06 | Buy |
| Synthonix | A61058 | (R)-2-Amino-3-methoxypropanoic acid >98% | 86118-11-8 | 5g | $110 | 2026-05-06 | Buy |
| Synthonix | A61058 | (R)-2-Amino-3-methoxypropanoic acid >98% | 86118-11-8 | 10g | $200 | 2026-05-06 | Buy |
(R)-2-Amino-3-methoxylpropanoic acid Chemical Properties,Uses,Production
Uses
(R)-2-amino-3-methoxypropionic acid belongs to O-methyl-D-serine, is a non-natural amino acid, and is the main intermediate in the synthesis of lacoamide. It has been widely used in pharmaceutical and other industries.
Synthesis
98026-05-2
4219-94-7
The general procedure for the synthesis of O-methyl DL-serine from 2-amino-3-methoxypropionamide was as follows: in small-scale experiments, ACL racemase (Locus: E01594) and PepB (Locus: D84499) were added to an aqueous solution containing α-amino-β-methoxypropionamide (4). The reaction mixture (20 mL) contained 2 mM pyridoxal 5'-phosphate (PLP), 0.1 M potassium phosphate buffer (KPB, pH 9.0), and 0.5 mol/L α-amino-β-methoxypropionamide (4). Subsequently, ACL racemization enzyme (3.0 mg) and PepB (1.2 mg) were added, and the reaction was incubated for 18 h at 38°C. The progress of the reaction was monitored by periodic sampling. D/L-α-amino-β-methoxyalanamide (4) and O-methyl-L-serine (5) were determined using HPLC equipped with a Crownpak CR(+) column at a flow rate of 0.5 mL/min employing 50 mM HClO4 as a solvent system, and the absorbance of the eluate was monitored at 210 nm. Upon completion of the reaction, O-methyl-L-serine (5) was obtained by deproteinization with trichloroacetic acid and separation by Dowex-X8 (H+) column chromatography. The isolated O-methyl-L-serine (5) (7.98 mmol, 950 mg) was recrystallized from a mixed solvent of water-methanol-isopropanol-ether to give white crystals with an enol purity of >99.9%. The product has a melting point of 211-213 °C (decomposition) and a specific rotation of 1/25D (c 1, 6 mol/L HCl).1H NMR (400 MHz, D2O) data: δ 3.24 (s, 3H), 3.78-3.81 (m, 1H), 3.83 (dd, J = 3.5, 9.8 Hz, 1H), 4.01 (dd, J = 6.1, 9.8 Hz, 1H).13C NMR (100 MHz, D2O) data: δ 177.3 (CO), 76.5 (CH2), 60.2 (CH), 56.7 (OCH3). Elemental analysis (C4H9NO3) Calculated values: C, 40.32; H, 7.58; N, 11.75. Measured values: C, 40.35; H, 7.54; N, 11.77. ESI-MS (m/z): 120.1230 [M + H]+.
References
[1] Tetrahedron Asymmetry, 2012, vol. 23, # 24, p. 1653 - 1656
(R)-2-Amino-3-methoxylpropanoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28675 | 58 |
| AFINE CHEMICALS LIMITED | +86-571-85134551 | info@afinechem.com | China | 15083 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
View Lastest Price from (R)-2-Amino-3-methoxylpropanoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | (R)-2-Amino-3-methoxylpropanoic acid
86118-11-8
|
$1.00 | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- (R)-2-Amino-3-methoxylpropanoic acid
86118-11-8
- $1.00
- 99%
- Career Henan Chemical Co
