4-HYDROXY-6-METHOXYQUINOLINE
- CAS No.
- 13788-72-2
- Chemical Name:
- 4-HYDROXY-6-METHOXYQUINOLINE
- Synonyms
- 6-methoxy-4-quinolone;6-METHOXYQUINOLIN-4-OL;6-METHOXY-4-QUINOLINOL;6-Methoxyquinolin-4(1H);6-methoxy-3H-quinolin-4-one;6-METHOXYQUINOLIN-4(1H)-ONE;6-methoxy-1H-quinolin-4-one;6-METHOXY-4(1H)-QUINOLINONE;4-HYDROXY-6-METHOXYQUINOLINE;4(1H)-Quinolinone, 6-methoxy-
- CBNumber:
- CB3149777
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD00014662
- MOL File:
- 13788-72-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6-Methoxyquinolin-4(1H)-one 98% | AS44207 | 1g | $28 |
| 6-Methoxyquinolin-4(1H)-one 98% | AS44207 | 5g | $70 |
| 6-Methoxyquinolin-4(1H)-one 98% | AS44207 | 25g | $245 |
| 6-Methoxyquinolin-4(1H)-one | 144080 | 5.00g | $533 |
| 6-Methoxyquinolin-4(1H)-one | 144080 | 25.00g | $1599 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
4-HYDROXY-6-METHOXYQUINOLINE price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS44207 | 6-Methoxyquinolin-4(1H)-one 98% | 1g | $28 | 2026-06-04 | Buy | |
| Activate Scientific | AS44207 | 6-Methoxyquinolin-4(1H)-one 98% | 5g | $70 | 2026-06-04 | Buy | |
| Activate Scientific | AS44207 | 6-Methoxyquinolin-4(1H)-one 98% | 25g | $245 | 2026-06-04 | Buy | |
| Matrix Scientific | 144080 | 6-Methoxyquinolin-4(1H)-one | 13788-72-2 | 5.00g | $533 | 2026-05-18 | Buy |
| Matrix Scientific | 144080 | 6-Methoxyquinolin-4(1H)-one | 13788-72-2 | 25.00g | $1599 | 2026-05-18 | Buy |
4-HYDROXY-6-METHOXYQUINOLINE Chemical Properties,Uses,Production
Synthesis
![5-[(4-methoxyanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione](/CAS/20180601/GIF/25063-43-8.gif)
25063-43-8
13788-72-2
1. 4-Methoxyaniline (1.27 g) and 5-methoxymethylene-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.82 g) were dissolved in 2-propanol (40 mL), and the reaction was stirred for 2 hours at 50°C. The reaction was completed by distillation under reduced pressure. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was washed with ether to afford 5-[(4-methoxyphenylamino)methylene]-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.98 g, 73% yield). 2. 5-[(4-methoxyphenylamino)methylene]-2,2-dimethyl-[1,3]dioxolane-4,6-dione (1.28 g) and biphenyl (5.2 g) were suspended in diphenyl ether (20 mL) and the reaction was stirred at 220 °C for 1 hour. The reaction mixture was purified by column chromatography in methanol-chloroform system to afford 6-methoxy-1H-quinolin-4-one (398 mg, 49% yield). 3. 6-Methoxy-1H-quinolin-4-one (398 mg) was suspended in diisopropylethylamine (3 mL), phosphorus trichloride (1 mL) was added, and the reaction was stirred at 100 °C for 1 hour. After completion of the reaction, water was added under cooling in an ice bath and the aqueous layer was neutralized with aqueous sodium bicarbonate. The organic layer was extracted with ethyl acetate, the ethyl acetate layer was washed with water and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by column chromatography in acetone-chloroform system to give 4-chloro-6-methoxyquinoline (375 mg, 42% yield).
References
[1] Synthetic Communications, 1985, vol. 15, # 2, p. 125 - 134
[2] Synlett, 2009, # 11, p. 1847 - 1851
[3] Synlett, 2007, # 14, p. 2205 - 2208
[4] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 42
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 14-15, p. 2445 - 2449
4-HYDROXY-6-METHOXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-HYDROXY-6-METHOXYQUINOLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49979 | 58 | |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8618071025641 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52704 | 58 |
| CR Corporation Limited | fred.wen@crcorporation.cn | China | 8645 | 58 | |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178 | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49895 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 |
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