(R)-3-Methylmorpholine
- CAS No.
- 74572-04-6
- Chemical Name:
- (R)-3-Methylmorpholine
- Synonyms
- (R)-3-MethyL;R-methylmorpholine-D7;(R)-3-Methylmorpholine;elagolix intermediate 8;Morpholine, 3-methyl-, (R)-;Morpholine, 3-Methyl-, (3R)-;(R)-3-Methylmorpholine(WX900060);(R)-3-MethylmorpholineortheHClsalt;high quality (R)-3-Methylmorpholine
- CBNumber:
- CB31561899
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD10698482
- MOL File:
- 74572-04-6.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (R)-3-Methylmorpholine Asreported | 284913 | 1g | $523 |
| (R)-3-Methylmorpholine Asreported | 284913 | 2g | $814 |
| (R)-3-Methylmorpholine Asreported | 284913 | 5g | $1274 |
| (R)-3-Methylmorpholine Asreported | 284913 | 10g | $2088 |
| (R)-3-Methylmorpholine Asreported | 284913 | 25g | $3894 |
| More product size | |||
| Boiling point | 137.1±15.0 °C(Predicted) |
|---|---|
| Density | 0.891±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 9.03±0.40(Predicted) |
| form | liquid |
| color | Colourless |
| InChI | InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m1/s1 |
| InChIKey | SFWWGMKXCYLZEG-RXMQYKEDSA-N |
| SMILES | N1CCOC[C@H]1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H319 |
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 |
| HS Code | 2934999090 |
(R)-3-Methylmorpholine price More Price(91)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 284913 | (R)-3-Methylmorpholine Asreported | 74572-04-6 | 1g | $523 | 2026-06-03 | Buy |
| Usbiological | 284913 | (R)-3-Methylmorpholine Asreported | 74572-04-6 | 2g | $814 | 2026-06-03 | Buy |
| Usbiological | 284913 | (R)-3-Methylmorpholine Asreported | 74572-04-6 | 5g | $1274 | 2026-06-03 | Buy |
| Usbiological | 284913 | (R)-3-Methylmorpholine Asreported | 74572-04-6 | 10g | $2088 | 2026-06-03 | Buy |
| Usbiological | 284913 | (R)-3-Methylmorpholine Asreported | 74572-04-6 | 25g | $3894 | 2026-06-03 | Buy |
(R)-3-Methylmorpholine Chemical Properties,Uses,Production
Chemical Properties
colourless liquid
Uses
(R)-3-Methylmorpholine is useful for the discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one, an inhibitor of Vps34 for the treatment of solid tumors.
Synthesis
119844-67-6
74572-04-6
GENERAL STEPS: A tetrahydrofuran (THF, 100 mL) solution of lithium aluminum hydride (LAH, 2 eq.) was cooled to 0 °C in an ice bath under nitrogen protection. A solution of (R)-5-methylmorpholin-3-one (1 eq.) in THF (20 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was cooled again to 0 °C and quenched by careful addition of water (2 mL), 2N sodium hydroxide solution (2 mL) and water (8 mL) in that order. After quenching, the resulting slurry was stirred at room temperature for 1 hour and then filtered through diatomaceous earth. The filter cake was washed with ethyl acetate and discarded. The filtrate was dried with anhydrous sodium sulfate, separated and concentrated to give (R)-3-methylmorpholine as a colorless oil.
References
[1] Synthesis (Germany), 2014, vol. 46,
[2] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 149
(R)-3-Methylmorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8828 | 58 |
View Lastest Price from (R)-3-Methylmorpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-02-25 | (R)-3-methylmorpholine
74572-04-6
|
$6.70 | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | (R)-3-methylmorpholine
74572-04-6
|
$6.70 | 1KG | 99% | 1000kg | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | (R)-3-Methylmorpholine
74572-04-6
|
$6.70 | 1KG | 98% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- (R)-3-methylmorpholine
74572-04-6
- $6.70
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- (R)-3-methylmorpholine
74572-04-6
- $6.70
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- (R)-3-Methylmorpholine
74572-04-6
- $6.70
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
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